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Could it be related to the type and intensity of activity that you do when you are not lying down? As a fitness instructor, I used to leadLead poisoning a very physical day. I didnt feel tired during work because I was on the go, but when it came to lying down and relaxing, not having to push through what I had to do, my whole body felt heavy, particularly my limbs. It is amazing what we dont feel when we are on the go, so it is probably an obvious question, but just wondering none the less.