Acute for over 2 years, please help

[GARBANZO]

Hello.  40 years old male got infected in September 2011 while unprotected sex. I wrote you message already but lost password.  Last blood tests shows first time HBS ab levels. STeff what u think pls???????

Doctor told me i dont need tretement and not to worry.  He sais I can not be treated becouse I have a mutant.  I live in france. Sometimes i feel tired, more than before having the virus.  I am healthy man who dont smoke or take drugs allways doing sports.  Many blood tests and everything in good health.  Not inmuno deprimed system. Sorry for english is really crapt.


          
9/ 2011

HBS ag = +
ADN =  3500 copies/ml
ALT and other liver enzimes  = normal levels  (asympthtomatic)
hbs ab = 0
hbc ab total = +

3/ 2012

FIBROSCAN = 4,2 kp (normal liver)
HBS ag = +
ADN =  1500 copies/ml
ALT and other liver enzimes  = normal levels  (asympthtomatic)
hbs ab = 0
hbc ab total = +

2/ 2013

HBS ag = +  , HBE ag = - ,  HBE ab= +
ADN =  600 copies/ml
ALT and other liver enzimes  = normal levels  (asympthtomatic)

anti hbs = 3

anti hbc total = +

[GARBANZO]

Yes i Will do.  

My doctor told me there is not need to do it anyway becouse it is just usefull to see response to treatements and he told me i dont need to be treated.
Becouse you guys are very kwonlegble i wanted to have your opinion. xs anyway.

[Rome70]

You are lucky to be in France and have good HbsAg quantitive test and very cheap too (15 euro)

Just get it done instead guessing ...

[GARBANZO]

Do u know if HBEag -ve has more chances to develop cirrosis and HCC than than the HBEag +ve????

If I do interferon how many probabilities of succes do I have  in % ( if my HBSag is lower than 1000 )  ?????

I DONt understand why u said that HBEag -ve is very bad becouse many therapies have for objective HBE seroconversion ins't is?

Regards

[stef2011]

only hbsag level in iu/ml and genotype can predict chances to clear

i ll try peg intf when hbsag reaches a good level, mine is still too high at 3600iu/ml and since there was no response to imiquimod intf also peg is unlikly to work

of course, as all of us, the hopes are on fast approval of myrcludex

[GARBANZO]

thanks stef.  u know what r the chances for me to clear with interferon peg??  will you wait for next generation cures??  

( I can tell u I contacted Cuban NASVAC chef project manager she told me that might be ready for end 2013)

[stef2011]

you dont look like a mutated hbsag, hbsab at 3miu/ml is still not protective and not totally unusual on hbv carriers, to know what is happeining we need hbsag quantity in iu/ml or full hbv genome test with the hbsag mutations (this is availabl e in some big italian hospitals which are research center too) but nayway we dont need to check hbsag mutations, it is not your case because hbsab is till too low

check hbsag level and if less than 1000iu/ml you can clear in weeks by pegintf plus zadaxin or plus simvastatin, once hbsag is undetactable hbv vaccine plus zadaxin should boost hbsab to more than 1000miu/ml and you ll be clear