Anybody know the future of REP 9AC on HBV treatment result recently?

[Skyclimber]

Heard that REP 9AC is a new drug for HBV and it can remove HBsAG at a high ratio. Pls check whether there is new information.

[MHMD]

- Do you mean that I use tenofovir for maximum 2 years, and if I can not clear the virues then I go to compo?

- what do you mean by vit d25oh>60ng/ml?

-  is this protocol same as in the following clinical traile

  ( http://www.clinicaltrials.gov/ct2/show/NCT00973219?term=hepatitis+b&recr=Open&rank=1http://www.clinicaltrials.gov/ct2/show/NCT00973219?term=hepatitis+b&recr=Open&rank=1 )..

thanks a lot...

[stef2011]

we dont know how many years rep9 ac will take to be available so it is definitely better to start sequential treatment by tenofovir and then interferon add on, do not start combo imeediately go for sequential

tenofovir 1-2 years
interferon+tenofovir 2years
if available add alinia too

make also sure to have vit d25oh>60ng/ml

[MHMD]

Hi,

  what is your suggestion do i proceed for the new protocol Comp(Inteferon+tenover)... or wait for this new medicine(REP9AC')?? .

please notice that I am HBe  negative..

  Thanks a lot....

[MHMD]

Hi,

  what is your suggestion do i proceed for the new protocol Comp(Inteferon+tenover)... or wait for this new medicine(REP9AC')??

[StephenCastlecrag]

Off treatment, three of these four patients are currently experiencing a
sustained immunological control of their infection (HBV DNA less than 500 cpm, and HBsAg  less than 10 IU/mL) for 24, 12 and 12 months respectively. The other four patients are experiencing partial immunological control of their infection with sustained greater than 90% reductions in serum HBsAg and 3-7 log reductions in HBV DNA.

[StephenCastlecrag]

One more time:

Off treatment, three of these four patients are currently experiencing a sustained immunological
control of their infection
(HBV DNA < 500cpm, and HBsAg  90% reductions in serum HBsAg and 3-7 log reductions in HBV DNA