Entecavir + Interferon combo

[cyrus131]

Dear all,

     I have been on Entecavir 0.5mg for over 6 years and my HBV DNA is nearly undetectable.  I will see my doctor tomorrow and what tests should I perform so as to assess whether I will benefit from the Entecavir + Interferon combo treatment (i.e. higher chance to achieve Hbsag seroconversion.)  Many thanks.

Regards,

Cyrus

[stef2011]

also consider to keep entecavir for 6-12 months even when hbsab becomes detactable, there are no guidelines for this but researchers that cure patients this way keep antiviral for 6-12 months after peg is finished just to be sure no relapse

[stef2011]

so happy that you cleared hbsag too, which week is 19 feb?

don t worry about difference in quant and qual, it doesn t matter and is not relevant here.now you need to monitor hbsab level and keep peg until a good level of hbsab is achieved

if you dont see an hbsab in 2-3months you can also try the following to stimulate immune system:
hbv vaccine
zadaxin
gcmaf

[yibok]

Hi Stef

The Hbsag levels of Cyrus and Otan were same . However Otan cleared it in 16 weeks . Whereas the Otan DNA levels were quite high at the start . Could it be the Simvastatin effect worked for Otan .

Thanks

[yibok]

congratulations Cyrus .Thanks for posting the data .

[cyrus131]

Dear Stefano and Studyforhope

I just got my latest qHbsAg result which indicates my level is <0.05 IU/ml as at 19 February 2014, meaning negative.  My last qualitative test on HBsAg and HBeAg was still positive as at 6 February 2014.

My questions are whether the threshold in determining positive / negative is different for the quantitative and qualitative tests?  

What should I do now?  e.g. check for whether I have Anti-HBs or to inject Hep B vaccine in order to achieve s-seroconversion?  If I do not develop Anti-Hbs, should I continue peg-interferon injections beyond 48 weeks?

Many thanks for your kind advice.

Regards,

Cyrus

[mustthinkpositive]

To Cyrus,

How is your other blood work like ALT and WBC/neutrophils level? Your treatment seems to be on the right, positive track and I wish you all the best.

Correct me if I am wrong but did you miss one dose because of flu?

Thanks.