HEP B

[hepbvictim]

I was first diagnosed with HBSAg + in 2003 tested HBV DNA which was undetectable (in 2005). didn't take it too serious for 4 years or lets say didn't know what to do with this??. Now in a routine medical exam, found HBSAg still +, ALT are raised to 120 rest of LFT are normal, HBeAG is negative but then Viral load is 11000 (not sure copies or IU, i know it makes a difference if these are copies or IU). some say should be on treatment other saying not. My doctor want me to undergo a Liver Biosy and I am not ready for this as have no problems or sysmptoms and only came to know about this through routine medical exam. Liver biopsy is scary and side affects and risks, what would you suggest guys??

[vachow]

Thank you for your response.  I never had my hbsag quantity checked before.  My doc always checked either reactive or non-reactive.  I don't think he would monitor my condition if I do start mono treatment with ntz, so I have to find out a way for that.  The fact that it will take 1-2 years for ntz to make hbsag negative is disappointing.  As you can tell, I don't like taking pills.  

Btw, how do I join the Alinia group?  And, where can I get this medicine?

[stef2011]

in any case do not choose an antiviral first because ntz or interferon cannot activate immune system at maximum when hbvdna is und

http://archive.mail-list.com/hbv_research/message/20100619.114243.077311f8.en.html

at the conclusions it says entecavir supress immune system and can lead to hbv persistance, i think that tenofovir and other nucs are the same when make hbvdna und but they cannot do otherwise since hbvdna positive makes resistance

[stef2011]

you should also check the following if you can because hbvdna detectable can have different meanings, it can be your immune system cannot see infected cells but at the same time it can be it is reacting producing hbsab and slowly decreasing hbsag, although the second is very very rare and the first veru very probable:

hbcab Igm quantity, if higher than 0.2s/co (active hbv) your immune system is reacting to a new assault from hbv.if lower than 0.2s/co (inactive hbv)  probability is that immune system is controlling hbv and slowly decresing hbsag or keeping stable

hbsag quntity iu/ml, it will tell us if you are inactive or active.hbsag<500iu/ml 100% inactive.hbsag1000-1500iu/ml active cronic hbv that can be in inactive state for certain periods
hbsag <1500iu/ml good probability of making hbsag negative by ntz in 1-2years or by interferon in 5-10years

[stef2011]

you should have checked hbsag quantity in iu/ml that can tell level of cccdna and if your immune system has got control over hbv.i wouldn't have stopped therapy but now you should check for the hbv mutations before starting again and choose between:

ntz monotherapy, no sides, no resistance, might be stopped if hbsag gets lower than 500iu/ml but i would point to hbsag negative with ntz if hbsag decrease

ntz+interferon, possible heavy sides from interferon but this should be the most potent combo.like for hcv 4weeks lead-in ntz mono and then interferon+ntz

ntz+entecavir or tenofovir or both

the good is hbvdna positive will henance ntz and immune response, so for any choice start with 4 weeks minimum of ntz monotherapy and then add a combo

my suggestion start with ntz mono 6 months and check hbsag and hbdna quantity, the doctor might help very little because all this is off label

alt will get elevated at the begning because as you can see you have infected cells producing virus (hbvdna detactable) but immune system cannot see them, once ntz is started immune system will kill them and hbvdna will decrease

please if you choose to start ntz PM me and join alinia group so we can all share results

[vachow]

I'm 28yrs old asian female, started treatment with Hepsera first to treat hep b, then doctor added enticavir.  After taking them for a few years, my viral load became undetectable, hbeAg negative and hbeAb positive.  I know it's not advised to stop treatment, but I made the decision to stop the treatment sept 2009.  My viral load stayed undetectable until march 2010.  Here are my lab results for march and June:

Mar:  virus DNA 63 IU/mL
         virus DNA 367 copies/mL
         ALT 25
         AST 30

Jun:  virus DNA 138 IU/mL
        virus DNA 803 IU/mL
        ALT 20
        AST 28

I visit this site from time to time and recently, I noticed the topic of Alinia keep coming up.  I'm going to see my doc next week, and I'm wondering if I should bring that up.  Or is he going to think that I'm crazy for wanting to try that.  

Also, I would like to know if you need prescription for Alinia.  

[stef2011]

Milk Thistle has been reported to have antiviral activity against hbv and hcv so that is probably it
UK medical care system is nothing good, no research. no updated machines tests and so on...so look for the best if you can, fibroscan and hbsag quantity in iu/ml is routine here in italy and you must absolutlely find them, biopsy not used anymore (only particular cases)

since our progress with nitazoxanide (alinia) on hbe negative/hbeab positive i strongly suggest to start it but you need a lab for hbsag quantity in iu/ml (abbott test kit) because your hbvdna will get und in a couple of days and then you have to monitor hbsag.

once hbsag will get negative and hbsab positive you are free of hbv, i got a 2600iu/ml drop in 4 weeks only and hopefully get rid of hbsag by one year, hbe negative have medium hasag at about 5000iu/ml (from as low as 1000 to as high as 10000) so getting it negative especially starting from 1000-2000 shouldn't be longer than 1-2 years

until now no sides from ntz, follow our alinia thread for more about it