Highly reactive HBsAg

[Mars86]

Dears;

I'm 27 years male , Chronic HBV in immune Tolerant Phase and still Immune Tolerant since I got diagnosed last year in Jan...

I was treated with ETV .5 since exactly 12 month and added TDF in the last three months .. DNA is about 240 iu/ml but HBsAg is highly reactive 130 000 iu/ml ... what is the meaning of this high value ? why it keeps increasing while DNA is going to decrease ?

base line DNA was more than 170 * 10^6 iu/ml ... Normal ALT/AST ..

[Mars86]

In case it doesn't go down (DNA) .. is it safe to take the three medications together ?

Thanks in Advance

[Mars86]

Thanks for precious advice :)

[stef2011]

of course it is if hbvdna stopped decline, while if it is still going down you better wait before peg add on

[Mars86]

I visited the Dr. today he advised with peg add on + etv and tdf ... what do u think ?  is it ok or not ?

[Mars86]

thanks stef for your valuable advice :)

[stef2011]

one good point of your status is that your virus should be wildtype, it has little opportunity to mutate with your low hbvdna so when immune system will be recovered hbsag shoudl be easier, at least theorically

anyway it is not good to have hbvdna detectable so if it does not go down to und by few months it is important to consider possible aid from ntz or ezetimibe