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Normal vit D levels are associated with hbsag seroclearance.

Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA  8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.
Best Answer
Avatar universal
that s good i think we hve to try to make it very high like 100ng/ml and see what happens, i guess the response might be very very slow like for my sister when hbsag is high and faster when hbsag is 1000-1500iu/ml

our experience here might build a good evidence if many participate
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i m sure if we did fibroscan after gcmaf it was already low because all her response was superfast thanks to gcmaf/vit d according to me:
hbvdna baseline 1.600.000iu/ml hbsag 13.000iu/ml
started tdf 3 dec 2013
hbvdna 490iu/ml 13 jan 2014
hbvdna und         8 apr 2014  hbsag 9000iu/ml
                       19 may 2014 hbsag 7000iu/ml

then lost response on hbsag, i think she lost the effect of gcmaf.she has felt incredibly good on gcmaf but she stopped it because she didn t like injections and the fact it s a blood derived product
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Wow, from F2 to F0 in 1.5 year, great. Did she took anything except tdf and gcmaf in that period ? Fibroguard or sth ?
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of course there are cases of fibrosis going down so fast on nucs too but they re not usual
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baseline fibroscan was 8.7kpa in aug 2013, she did about 3 months of gcmaf and then started tdf, the next fibroscan in feb 2015 was 4.6kpa

this could be due to tdf but i don t think so because antivirals are no so fast,i think that if we checked few months after gcmaf it was already low
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Very nice decline, keep posting about her ! Did Fibroscan also went down when she started TDF ?
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no not interested to change anything, she s having zero issues from tdf, kidney function perfect, she feels immensely better than before using antiviral

Any plans to add INF?

no intf, she tried intf when experimental when she was a teen and sides were so bad she didn t even make any tests for decades or doctor's visits.she doesn t care about hbv, she only cares to feel well
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wanted to update my sisters hbsag decline on tenofofvir and vitamin d3 10.000iu daily (sometimes a little more when she is sick)

baseline 2012 from 18.000 to 21.000iu/ml
started vit d supplementation in 2011
before tdf dec 2013 about 13.000iu/ml
end of 2014 9000iu/ml
2015 8000iu/ml
jun 17 2016 5000iu/ml

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2 Comments
Great. very good decline on just TDF and Vit D 10k. Great results. Will she switch to TAF when it becomes available?
Great. very good decline on just TDF and Vit D 10k. Great results. Will she switch to TAF when it becomes available? Any plans to add INF?
Avatar universal
with such low dose i take 200mcg but also 90mcg is ok

an expert doctor on coimbra protocol suggested 600mcg for 50.000-100.000iu doses

vit d3 needs magnesium, vit a but low max 3000iu daily, vit k2 mk7, none of these have sides unless there is a deficiency among these or the brand has rancid oil or emulsions with vit d

try to supplement 400mg of magnesium daily, i use drbest which has a type of mg easily absorbed, i dont remember its name
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How much vitamin k2 mk7 would you take with 10000-15000 iu vitamin d? It seems like vitamin k2 mk7 makes my eye twitch and gives me a sickest feeling. I take 100 daily. I was trying to take 200-300 a day but couldn't handle it.
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update on my use of vitamin d:

because of the issues with creatinine, i also checked my pth and it had gone to 5pg/ml (norm 10-80) too low, so i lowered my dose to 100.000iu daily, then to 50.000iu, then 40.000iu and then stopped for 3weeks

then i restarted with 15.000-20.000iu daily which looks enough to keep pth 17pg/ml, i added also vit A (not in betacarotene type), creatinine is now 0.68 (norm 0.6-1.3)

the fact that now i need normal vit d levels to lower pth means that now my vdr receptor is working different and much better.i dont know if this reflects a new balance with hbsag since i dont have yet results
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10915849 tn?1415112928
Thank you
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it was posted on another thread, should be on the market in cuba by this year and south america next year.
combo with nucs or peg should help immune system clear hbv, they have not published hbsag quant data so difficult to say how much it can help
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10915849 tn?1415112928
Hi Dear stef

How are you?

Is the cuban vaccin a theurapetic one or?
Did this vaccin passed all the trials stage?
When is it going to be available ?

Thank you
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dont know if it can work on anybody, i took it few weeks after creatinine increased so very early intervention
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i ve had issues due to my cirrhosis since 2010 and creatinine increased also on etv.i was suggested fibroguard and it made creatinine normal by 1 month so i could use tdf too
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i am interested in the heptech protocol for kidneys. i have a creatinine of 1.3 and was wondering if the heptech will help with it. Were you at 1.2 creatinine before and dropped it to 0.8?
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update on my use of vitamin d:

after taking antibiotics this winter i got a increase of creatinine (antibiotics are toxic for kidneys and some brand may even lower creatinine clearance while on it, it happened to me), this is not resolving with creatinine 1.2 high range of normal.since also tdf is toxic on kidneys with damage i will stay off vit d for one month and restart full heptech protocol to make it as before antibiotic use 0.8

i hope hbsag will at least stay stable around 800iu/ml but anyway with cuban vaccine close to available this year and rep9ac advancement and my low hbsag i think i need not to worry about hbsag anymore
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Ty stef
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no not hypo, hyper
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Not hypocalcemia?
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the target is intact pth below lowest of normal

we need exactly lowest value of normal range, never close to undetectable because pth so low makes hypercalcemia
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Ty sir
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there is no target for us on vitd25oh brcause it does not measure vit d, the target is intact pth below lowest of normal
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Sir, what is the target range of vit25OH?
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