Please find attached reply from Mr Ron from Isramed.
The question to Mr Ron was could the Vaccine be shipped to Casablanca, Morocco?
Reply from Mr Ron
Thank you for your interest in IsraMeds.
Sci-B-Vac is available and can be sent to Casablanka, Morocco by cold chain shipment(refrigerated all the way and not in bags)
Sci-B-Vac is available as 2.5mcg / 5mcg / 10 mcg. Prices start from $77 per ampule to $297 for the 10mcg ampules.
There is a 15% discount if you decide to purchase the 25 ampules original package.
Please note you must calculate 3 doses per person meaning that 12 ampules would be enough for 4 individuals.
Please specify the dose, quantity and prefferance of shipment method and I will gladly quote you prices and ask our accounting dept. to prepare a proforma invoice for your purchase.
Also please reply with you telephone number so I can explain the details...
More question pending reply:( from soflab to IsraMed Mr Ron)
Could you please relay the list of countries you can ship this SCI-B-Vac.
As i am a member of www.medhelp.org (soflab) hepatitis B Forum, lots of members all over the world want to try this vaccine for the sake of the Forum trials could you relay what would be the price for our members in medhelp.
does it make any sense to try this vaccine during pegintf or for those with very low hbsag levels with monthly injections in a skin area previously treated with imiquimod (with also zadaxin added for the lucky ones who has it), the vaccine seems inexpensive and if it makes no harm it would be a good try
are there any trials on these new hbv vaccines in combo with peg intf and zadaxin, i couldn t find any?
An intradermal injection into an IMIQUIMOD pretreated area as adjunct therapy makes sense. But it would be so much better, if it also contained core particles. Simultaneous thymosin alpha, as shown in the Canadian trial is also likely to help. That trial, used to stabilize seroconversion, used only the monovalent, not the triple antigen vaccine.
You have mentioned earlier that even with very low hbsag quantity even at the limit of detection of 0.05 iu/ml we still have millions of hbsag particles per ml. Vaccine shot would just increase the number of these particles , so why vaccine should help to develop antibodies? In fact blood of a person with hbsag and zero VL is vaccine itself... I am speaking about monovalent vaccine.
Thank you for you great assistance to this community!
You are correct, indeed many years ago the first vaccines were made from patients blood, after inactivation of the virions. These vaccines were actually much more potent than the later recombinant ones, they did contain pres1 and pres2 components and the denatured virion remnants certainly helped as well. Robert Neurath based his famous paper in in the journal nature showing "a strong T cell response to pres1 in man" on the study of such vaccinees.
If an effect of therapeutic vaccination in borderline "pushover" situations can be expected, then only because a strong adjuvant is simultaneously present in the application or at the application site, like cpgODNs in the dynavax vaccine, or thymosin alpha, or the super antigen HBV CORE PARTICLES or maybe IMIQUIMOD and the presence of all three surface antigen types S. M. and L.
It is the activation of the local dendritic cells that determines the quality and quantity of the immune response to any vaccine.
The regular recombinant S only vaccine will have no effect, the alum used as an adjuvant is too weak and does not stimulate T cell responses.
Many thanks for your comments !
Could you also please comment on vit D supplementation? There are many studies that prove that vit d stimulates innate immunity and down-regulates the adaptive one, does it mean that vit d supplementation should be stopped on the stage when hbsag is low and you expect the hbsab to come up?
There is no good answer to the question of vit D intense supplementation effect on the stages of spontaneous or induced hbsag seroconversion.
I would remain in the range between 60 and 80 until clear evidence emerges to suggest otherwise.
My understanding is that Sci-b-Vac is a prophylactic vaccine, but you seem to imply that it can be made to be therapeutic by using it together with potent adjuvant?
Sci-b-Vac contains in addition to the s antigen, the preS1 and preS2 antigens, is thought to be more expensive to produce, hence its smaller share of the market.
Is it the presence of the preS1 and preS2 that makes the difference? But doesn't the HBSag sub viral particle also has preS1 and preS2?
The recombinant monovalent vaccine S particles, derived from yeast as in engerix, do not contain any trace amount of the pres extensions of the S protein. they also lack certain processing signals, that might be important in immune recognition, like carbohydrates, that are present in the production from chinese hamster ovary cells.
The natural 22nm surface antigen particles contain very small amounts of preS2 and extremely small amounts of preS1.
In HBV serum also exist so called filaments, which are elongated S-particles, they contain a small percentage of preS1. The filaments only comprise a small portion of all the particles.
So it might make some sense to concentrate these antigens on an activated local area of entry tissue, like the skin, onto adjuvant activated dendritic cells. Circulating particles are not very immunogenic, since they have already penetrated the natural barriers where the immune response gets started.
The reason for the small amount of market shares for the Israeli vaccine is not the higher production cost, but simply the overwhelming cost of getting it approved outside of Israel.
And yes, it is not a therapeutic vaccine. But if properly adjuvanted, it seems to qualifiy as a first choice if one has to use currently licensed vaccines in combination with an additional adjuvant, due to its extra antigen content, that is likely quite important in the enhanced response repertoire.
And one must stress that its effect, even when adjuvanted as discussed above, will still be small, maybe able to push a slow natural seroconversion into a stable phase.
I am afraid that this will still be true even for the new planned therapeutic vaccines.
POSIBILTY TO BE DELIVERED THE SCI-B-VAC in Madrid Spain. I will copy and paste all the replys from ISRAMED. Please let me know any member in europe willing to have the Vaccine that i can included to my 6 doses to be delivered on the same date 18th August TBC.
The price for 6 ampules would be $297*6*0.85 = $1514.70 + Delivery Charge.
We are looking into the preffered delivery option and will update you shortly.
There may be an option that we meet you on your connection in Europe(Madrid for example) on the 18th or 19th and hand deliver it to you, this could save you some time effort and moneywith beurocracy at the Morocco customs especially as this is coming from Israel.
Thank you for you prompt email and making this delivery in an efficient way by proposing Spain Madrid.
You sound like you have a better understanding the Moroccan customs since it was my concerned if DHL or FEDEX will be able to transport medecine to Morocco. Not only this but also to send foreign money you need special permission from Rabat capital city and here again time consuming.
So the Solution is Madrid and since i am Cansdian holding a Canadian passport it should not be an issue. I found a flight Casablanca leaving on the 18 August @1555 arriving to Madrid Barajas Ter 4s @ 1835. The return ticket is on the 19 th August @ 2015. So i need your confirmation that the Vaccines have to be delivered to myself on the 19 August between the hours 0800 to 1700. Also where to meet it will be idle next to the Airport if not in the airport itself. So please confirm this and i will go ahead with the airfare booking and i will send a copy of the booking proof of me showing up at appointment for collection.
Thanks once more and i hope that we can work in the future for the members of medhelp and being able to make their life easy by giving them the chance to get hand on the SCI-A-vac since it is concidered the most valuable vaccine but unfortunately only comercialised in Israel. Also i already posted Mr Ron reply to the medhelp members for possible shippment so you should be hearing soon for these guys. After research j understand that the company owning this Vaccine had open an office in Madrid for future potential sales in europe afterghe vaccine will get EU approval any news in this regards?
Awaiting your go ahead for booking my flight to Madrid.
Stef please be advised that i have one Connection a Fiend of mine in Telaviv he will be checking the exact price for the Sci-B-Vac from a walk in pharmacie in isreal and i beleive that the price should be 50% or more less than the 297usd through an online pharma in israel. i will update on this as soon as i get an answer from my friend.
infact all the ting looked very expensive, i though the vaccine was about 77usd.....
since we dont know if the vccien works therapeutically it would be best to wait for approval in europe or just purchase in case of very low hbsag or after pegintf
the idieal use would be:
48weeks of pegintf (any type, mono, sequential/combo with nucs)
if hbsag is low at 48weeks like less than 500iu/ml try the vaccine with imiquimod cream on site of injection
my guess on vit d is that it improves response by antimicrobial production making it very high levels but we dont know how it worls with vaccines.
there are of course few studies on low ranges like less than 10ng/ml with less response to vaccine but there is no study on the very high levels like 100-165ng/ml so better stay with studyforhope suggestion less than 100ng/ml
first have a abseline test of d25oh, then start taking vit d3 10.000iu daily and vit k2 400mcg daily, if you but d3plus from biotech it has already k2 in it and pills are 5000iu so you ll have to take 2 pills daily
avoid all diaries products (milk, cheese and so on) and check monthly d25oh, serum calcium and ionised calcium
when you reach about 100ng/ml lower to 5000iu daily and see if it stays, also check yuour baseline hbsag quantity and retest after 3-4months on serum levels 100ng/ml to see if it has any effect on hbsag
we think it is worthwhile for people having lesss HBV load to go ahead and try this vaccine Sci-B-Vac there is no harm of doing so if not beneficial.
So to my understanding and stef can correct me if i am wrong,
(An affected person readings should show the following= less HBV load)
-Hbsab: pos is favorable but even with neg can try to use the vaccine since the aim is to boost anti bodies and get them to work proparly.
-Hbe ag : neg
-Hbe ab: pos
-HBV DNA: less than 1000 iu/ml
-Hbsag quant: less than 1500iu/ml genotyp A or D
100iu/ml genotype Bor C steff could you correct please if i am wrong.
-HBc Igm= pos=accute no harm if this latter was neg = chronic to try vaccine
-double check vitd level if low try to get vit d3+vitK2 or vit D plus to achieve 100ng/ml
-HBe Negative. 0,180
-HBEab positive 0,008
-HBs IgG positive 0,010
-HBC IgM Negative 0,058
-HBSag Quant. 154,91KUI/L reactive architect Abbott
HBVdna Awaiting result have been asked by the french lab to send a new blood sample which was sent today (I suspect they had und dna to bo comfirmed)
This latter result 3 months ago 20 Juin 2013:HBVdna 1170 copies/ml
-Vitamine C 41umol/l
-Vitamine D 49 nmol/L. 20ug/L
-Genotype awaiting result along with latest VBVdna?
Fibroscan not available will try to get it done in spain.
So Stef i would say after these results is worth trying the Vaccine and since i could not get ln hold ghe Sci-b-Vac. I will try engerix also try to boost Vitamine D. Any other suggestion please let me Know.
Is my friend result worth trying the Vaccine or he had higher HBSag Quant and required treatment to be lowered bearing in mind he was diognosis hep B 3 years ago his doctor never performed these tastes in details as i was the one suggeting he complete this full list of test i learned from this Forum.
stef just confirmed with the lab it is: 154.91UI/ml
And same 5000 UI/ml for my friend.
Steff just to clarify the above in my case you meant that i use the vaccine+ pegintf+ D3 is this corect.
- my friend case has higher Quant so vaccine is useless for him and you meant that there is a slight chance if he uses pegentif + vit d 3 for 24 weeks he might clear it if not we can assess after 24 weeks in his case please confirme that it is no problem to stop pegintef after 24 weeks on both cases mine and my friend case.
Hi newtr as i am muslim we do fast one month out of the year from sunrise to sunset before readings were 1280 copies 220 ui/l. After ramadan the body system got rested and DNA was lowered to 300 copies or 60 ui/l
Hi stef i have just received the result for both my friend and I we both have gynotype D. I went with my friend to his doctor to discuss both result and he was oposing that my friend take pegint also in my case. Therefore, i will need to head to france to see another doctor to have a second opinion on pegint intake and meanwhile i will carry on taking Vit D 3 my brother in germany confirmed that they have this latter on 5000 iu so he will be sending me some boxes. Yesterday i arrived in Brasil couldn t find the dosage only found vit D drops 1 drop = 200Ui. so the pharmacist said 25 drops = 5000 Ui bearing in mind that this box state only vit D and not vit D 3.
Also i found another box stating Calcium 500 mg+ D3 brand Sundown natural i got one box of 180 pills i am not sure if i should take this one or not 3.1 mcg de vit D.
I found it from previous post:
Majority of Asians had genotype B and C (82%).
Majority of Europeans had genotype A and D (84%)
North Americans mainly had a mix of genotype A, B, and C (81%)
South Americans mainly had genotype A and F (78%)
Loss of HBsAg differed according to HBV genotype: 14% for genotype A, 9% for genotype B, 3% for genotype C, and 2% for genotype D.
One year of Peg-interferon alpha-2b for HBeAg-positive patients led to HBsAg loss .Peg-interferon alpha-2b is the best therapy to achieve HBsAg clearance in patients with genotype A.
Also from other researches:
Genotype C&D have higher risk of liver and cancer deseases
Geno A&B higher rate of hbeag & and hbeab seroconversion
Geno A&B respond to interferon
In my case as i am falling under the worse geno D is this latter responds to interferon & and pegintef treatment is there any risk of mutation and resistance in case of pegintef treatment in my case ?
Wouldn t be wiser after finishing vitd3 intake and vit d3 is higher to double check HBSag quant and HBV dna if it s und or lower result than august result to try first vaccine and leave pegint treatment as last resort.
i also have genotype D and it is no that bad on pegintf, it is bad for liver cancer but as long as we get low hbsag it responds to pegintf
the worst genotype is C for both clearance and liver cancer
Wouldn t be wiser after finishing vitd3 intake and vit d3 is higher to double check HBSag quant and HBV dna
of course it is important to check baseline and then every 3months to see if they are declining.i think the boost of immune system by vit d requires long times to see an effect, like every 6 months hbsga and hbvdna monitoring but we can do it every 3 months too
if it s und or lower result than august result to try first vaccine and leave pegint treatment as last resort.
no hbvdna und has no effect on vaccine, only having hbsag and hbvdna und it is wise to try vaccine
Mr Ron from ISRAMED confirmed that the SCI-B-Vac can be send via freight to france or Spain. In my case he could use a sister company Onconsult based in Cyprus to send the vacccine to Morocco shipping cost around 377 usd.
Also he said:
Please notice that Sci-B-Vac is not available for individual use purchase by pharmacies in Israel or anywhere else in the world and we have been designated by SciGen(future SciVac) the Mfc. as their patient named basis distributor.
too complicated and strange after all it is a stupid vaccine.
since vaccines have been carriers of anything in the past like viruses, toxic substances and so on, i d never use a vaccine this way.what if the vaccine contains mercury or other substances and there is a bad reaction, who can we sue?
Well stef i need you explain please in previous post you mentioned that the vaction is the best on the market and after research i posted few people during the trial 10 persons developed lupus desease and i was concerned since i have jessner and kanof desease it would be bad for me to get it. So please before i make any payment and waste my money and more important japrdize my health could you clarify on the above statement.
we need to buy it in a very clear way and from public sources like a pharmacy, this looks like black market and vaccines can be too dangerous, i thought this hbv vaccine was sold in the pharmacy like any other vaccine
Stef please follow corespondence from latest to old with isramed and let me know what you think is it still concidered black market all my blood and previous medicals were sent to isramed doctor for a prescription:
I am glad to tell you that we received your prescription.
We are m/p going to send a currier in the next 3 days to Madrid.
If you are interested that we bring the Sci-B-Vac with us please update me.
I will transfer all your papers to our doctor and revert once I have an answer from him
This is very problematic. I thought you have a prescription from a Morocco doctor...
We will need you to send us the the medical file and at least a recommendation if not a prescription of your treating
Ron you can get me an isreali doctor prescription as discussed in the past because i am at sea.
The total price would be $297*3 + $377 = $1268.
Please send us your prescription and full address to begin the proccess ASAP
while taking vit d3 supplements and making vitd25oh>100ng/ml we need this no calcium diet because the absorption of calcium in the gut is increased very much so we dont need the foods with too much calcium
Just to give an update i was able to get 4 ampouls of the isreali vaccin through isra med and www dot onconsult ******* which air freighted these later to my home Casablanca.
I am aboard bow working due off the 2nd of Feb and the first dose will be taken by myself for the sake of all the HBV carriere with verry low figures.
my latest one december 2013.
HBSag: 150 iu/ml
HBV DNA 60 iu/ml
vit d3: 72 ng
up on arriving home i will take another set of blood test before taking the vaccin shot.
Negative no news from the company itself but that is my goal to see once i get the shots. but the isra med had my blood test and that was their doctor who autorise the shipment and prescribed the medicine and as explained to me that this vaccine is not sold in the pharmacy and only used for special cases and isra med is the only one which has the right to sell this vaccine overboard from isreal.
Since isramed is the sole representative for the vaccin could you please get me some info from SCI regarding the vaccin. Other medhelp members are waiting for my result i will take the first shot end of March. So Medhelp members have the following questions.
any update about the Scigen Israel Sci-B-Vacvaccine?
can you ask them if you can increase response to it by use of peginterferon or imiquimod on skin where you inject it?
i guess they have tried peginterferon at least on animal model or vitro
thanks for the above hint gcmaf. it appear that this one is a releive of my big concern about devoloping lupus after SCI-B-Vac. Could you please relay a a good brand can it be purchased via web. i shall wate on SCI answer before the shot to be sure if a positive combo.
What does GcMAF do?
The GcMAF Conference 2013 showed GcMAF is a far more powerful molecule than we thought, both in terms of the science, and doctors’ results. In stage 4 cancer, some doctors who choose the right complimentary therapies, such as those listed on our “Treatment Strategies,” are saving every patient. We’ve had complete successes with many common cancers including prostate lung breast and melanoma, but a little with leukemia too.
The immune system can eradicate chronic inflammation, bacterial and viral infections, and our GcMAF has been successful here, and with Autism, Chronic Herpes, Chronic Acne, Chronic cirrhosis of the liver, Chronic kidney disease, Chronic depression, Colitis, Crohn’s, Fibromyalgia, Hepatitis, Herpes, LMBBS, ME/CFS, Osteoporosis, and various types of Immune dysfunction including allergies. Research shows GcMAF can reverse HIV, Parkinson’s, and prevent deterioration in multiple sclerosis (MS) and ALS, and in its role of immune system regulator, can reverse diseases that attack the immune system like Lupus and Arthritis. And is effective with wound healing.
these are the results of 31 late stage 4 patients in the trial of the swiss clinic of gcmaf.eu, all failed conventional therapies and few months left to live.tumor reduction of from 6.8 to 49.2% and this is already in 1-4weeks of treatment.of course in the clinic they inject very high doses of gcmaf close or in the tumors to achieve such results.this is goleic (gcmaf+oleic acid)
as regards lupus you have to look for this study:
39: Yamamoto N, Naraparaju VR, Moore M, Brent LH.
Deglycosylation of serum vitamin D3-binding protein by alpha-N-acetylgalactosaminidase detected in the plasma of patients with systemic lupus erythematosus. Clin Immunol Immunopathol.
1997 Mar;82(3):290-8. PubMed PMID: 9073553.
Stef now that they have this web site you can get in touch with them and ask all the questions you want via website. on my side i will suggest to Mr Ron to see our page in here to try to extract our questions and find answers to them as well as put them under their FAQ in there web site.
As a member of medhelp.org Hepatitis B community, I would suggest that you visit the bellow to link related to SCI-B-Vac in order to answer FAQ by our members. This will help filling the FAQ as well on your new website created on 2014 by Onconsult.
Understood stef i will try to get my first shot tomorrow with God will for the sake of the hep b comunity. K need all your prayers please pray for me as i am afraid to get my situation worse knowing i have jessner and kanof anx afraid this will advance to lupus by taking this israeli vaccin.
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