Tenofvir is the best at the moment

[Jeff912000]

http://www.natap.org/2013/APASL/APASL_30.htm

Six Years of Treatment With Tenofovir DF for Chronic Hepatitis B Virus Infection is Safe and Well Tolerated and Associated With Sustained Virological, Biochemical, and Serological Responses With No Detectable Resistance


Reported by Jules Levin
Asian Pacific Association for the Study of the Liver (APASL) Liver Week, June
6-10, 2013, Singapore

Naoky Tsai1, Maria Buti2, Edward Gane3, William Sievert4, Ira M. Jacobson5, Phillip Dinh6, John F. Flaherty6, Kathryn M. Kitrinos6, John G.McHutchison6, George Germanidis7, Patrick Marcellin8
1University of Hawaii at Manoa, Honolulu, HI, USA; 2Hospital General Universitari Vall d'Hebron and Ciberehd, Barcelona, Spain; 3Auckland City Hospital, Auckland, New Zealand;
4Monash University and Monash Medical Centre, Melbourne, VIC, Australia; 5Weill Cornell Medical College, New York, NY, USA;
6Gilead Sciences, Inc., Foster City, CA, USA; 7AHEPA University Hospital, Aristotle University Medical School, Thessaloniki, Greece; 8Hopital Beaujon, Clichy, France.

No renal damage.  Even 74% of patients with cirrhosis were no longer cirrhotic
after five years of treatment.

[mustthinkpositive]

Hence I think REP 9AC plus IFN will be the one. Apparently according to their website, this combo trial is going on right now.

[Jeff912000]

I fear replicor is also just the beginning of a cure.  It blocks the HBSAG secretion and allows the body to become antiHBS postive.  However, it does not clear the intranuclear ccdna.  Our immune system will still need things like peginterferon alpha and lambda to keep up the ccdna clearance.  


We must all work hard like steff to continue finding drugs or substance which may reduce HBSag.  Replicor is just a piece of the puzzle for a cure
.  

[veteranB]

Very good. But lets focus on the cure. Rep9AC we want NOW!