hbv and alinia=very very good news

[stef2011]

good article about first hbv patients trying alinia over one year in mono tx and 1 patient in combo with adefovir

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670405/

mono-tx with the highest hbe and hbsag loss, no resistance, no sides.i think we should start to use it very soon in combo with antivirals since it looks the best medicine for hbv by far.
at the moment we don't have a tx with no sides and no resistance which leads to hbsag loss in a very high percentage and according to this article it is synergistic with nucs and interferon

alinia is already on the market FDA-approved treatment for Cryptosporidium

[April63]

Hello,just a one note about the very first first article.
It says that a formal phase II study is being planned for 2009. It's already 2010. I've checked the clinical trials and there isn't anything right now going on in this matter. Has Romark stopped with these promising trials? Do you know,Stefano, or anybody else,anything about it?
I  live in Canada. Just out of curiosity I had called yesterday my regular pharmacy to enquire about Alinia. They don't have it in stock but could order it for me anytime. Of course I would need a prescription. I double checked if it's the original or generic. It's the original. But the pharmacist told me that there are many different kinds (dosage). What dosage do we know,is the right dosage for HBS? My husband is on Viread.I wouldn't use Alinia without the doctors approval but it's good know all the other options,for the future.:) Kind regards-April.

[stef2011]

http://www.merlonipharma.ch/

this is a real pharmacy, i have bought medicine online and in their shop, it is in Switzerland (on italian borders) and products are 100% safe, i just emailed to check they have alinia and generics

prices are almost the same or little cheaper than other pharmacies (i compare to italian ones which are usually expensive) but you are 100% sure you are buying Alinia® (nitazoxanide) compound

[stef2011]

by the way i also checked hbsag seroconvertion rates with all antivirals, adefovir in monotx as almost 0% chances of seroconvertion (natural seroconvertion is 1-2% per year), so the best combo chances with alinia are probably with 3, 2 and 1, theoretically alinia is also the best combo the prevent resistance since it works against all resistant strains and has no resistance

1 Entecavir           5,1%
2 tenofovir              6%
3 tenofovir+ftc   10,3% per year (early data on hiv coinfected patients)
4 adefovir              1,9%
5 LAM                     0%
6 seroconvertion and loss hbsag 1-2% per year naturally

[stef2011]

i have found other info

treatment of a patient refractory to lam in 2006
http://www.hivandhepatitis.com/2006icr/ddw/docs/061606_d.html

in july 2008 there are reports that talk about alinia+entecavir and alinia vs entecair trial, any data from this would be very very interesting and if available i would start alinia now (page 14):
http://www.treatmentactiongroup.org/assets/0/16/42/196/198/bfb084dd-e770-4319-8df1-a0efbea7a08d.pdf

i have sent an email to romark and asked if entecavir and alinia work in synergism or at least if they have in vitro data to exclude interference, i do hope they can give some data already.

point of view of HR on romark company and if their data is reliabe or too optimistic like big pharma makes usually (these posts are from jan 2008 so it considers only for hcv tx):
http://www.medhelp.org/user_journals/show/2391

[April63]

Hi Stefano. Thank you for valuable information.-April

[stef2011]

thanks for the link, it is very useful info

i found canadian pharmacy too the other day and that's the only one i would trust becuase you have an address and a phone number, so we can check if it is a real licenced pharmacy.
i wouldn't trust any other source becuase it is too dangerous to buy medicines from india/china/3d world countries online even if nitazoxanide is a very easy chemical.

i guess the best way is to buy alinia from canadian pharmacy and then check with romark if it is their product by serial numbers on medincine box.

in any case i wouldn't mix antivirals other than adefovir until we have some trials that confirms alinia works synergistically also with entecavir/tenofovir.
it would also be very good if anybody could get in touch directly with romark in tampa and see if they have more info on use for hbv, the article is from 2008 and pubblished april 2009 so i guess they have some more info by now.