hbv and alinia=very very good news

[stef2011]

good article about first hbv patients trying alinia over one year in mono tx and 1 patient in combo with adefovir

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670405/

mono-tx with the highest hbe and hbsag loss, no resistance, no sides.i think we should start to use it very soon in combo with antivirals since it looks the best medicine for hbv by far.
at the moment we don't have a tx with no sides and no resistance which leads to hbsag loss in a very high percentage and according to this article it is synergistic with nucs and interferon

alinia is already on the market FDA-approved treatment for Cryptosporidium

[veteranB]

So how do people do with Alinia?

[stef2011]

Recently my HBV viral load increase to 500,000 copies/ml.

some are trying mono but i think with high viral loads it can work only with interferon, entecavir or tenofovir combo
it acts on immune system and lowers hbsag not hbvdna, so mono might take years to get hbvdna und, my sister is using it mono and close to 6 months, i will post her results in october.
it works on hbe negative, many asian hbe pos are trying it too but results are very very slow

hepatitis technologies anti-fibrotic protocols
never heard of these

Can I take Alinia with their Nutraceutical Liver support system?
don t know

I am only 155lb's do I need to dose at 2g/day or I could I get by with 1.5g/day?
you have to try doses and see which one lowers hbsag, higher bmi has lower response on ntz

Should I really take it with a high fat meal?
absorption is about 50% more and half-life in the blood increases but i don t use fat meal and just take ntz every 6 hours (at 7 hrs no drug effective anymore)

better combo with antiviral, entecavir has no sides if you have no lam or adv use and checked you have no resistance mutations it is the best combo drug.if you don t have these tests available tenofovir is safer for resistance and it has sides on less than 1%.
interferon has many sides so i'd not choose this

[morethenaconqueror]

Hi Stefano,

I have been using hepatitis technologies anti-fibrotic protocols for over 4 years with great success. Recently my HBV viral load increase to 500,000 copies/ml.
Can I take Alinia with their Nutraceutical Liver support system?
I am only 155lb's do I need to dose at 2g/day or I could I get by with 1.5g/day?
Should I really take it with a high fat meal?
Can I take only the Alinia instead of a anti-viral as I find the side effects greatly decrease my quality of life.

[stef2011]

if you reached hbvdna und on sebvivo within 6 month keep this monotherapy and check hbsag quantity, if it doesn't decrease switch to another antiviral like etv or tdf

as to the combo the problem is we have no data on combo sebvivo+alinia, probably because sebvivo is not a potent antiviral so there is no need to check with this one and since this has resistant mutation concerns i would never suggest a combo with this one

the only situation for a combo with alinia would be to switch to tenofovir or entecavir.if you don't see any decrease in hbsag talk to your doctor about changing antiviral to tenofovir or entecavir.also tell your doctor that recent data from vienna congress says that hbe seroconversion is not durable with antivirals and that therapy should be continued until hbsag seroconversion, in this situation tenofovir or entecavir are better option
the only case to keep using sebvivo would be a continuous decrease of hbsag and hbvdna und

[anjan8808]

Hi Stefano

Thank you so much.

I am HBeAg -ve before the treatment also based on the viral count(2500IU/ML and SGPT 76) doctor prescribed me Sebivo.  
So it is better to start the alinia once the HbsAg level drops to below 500 iu/ml and not with the sebivo combo.  Correct me if my understanding is wrong.

Thanks for the help.

[stef2011]

as to hbsag quantity make blood test with iu/ml unit, other tests are not accurate for quantity although i know that 200-300s/n is a low quantity usually found on inactive carriers

when hbsag reaches 10iu/ml seroconversion is very almost certain at about 90%, on hbe negative hbsag less than 500iu/ml is a very good baseline condition for seroconversion