how to interpret HBsAg with titer eclia

[michaelyuri]

hey guys!

Can somebody help me to interpret my HBsAg with titer eclia? last Sept 11, 2008 and just recently Dec 2,2008 i took the exam. The results were like this: Sept  11, 2008 HBsAg with titer eclia=1,279 reactive,  Dec 2,2008 HBsAg with titer eclia=1,500 reactive still, Anti HBs= nonreactive on both dates. I am a chronic inactive carrier. what do they mean? are the results indicative of a favorable condition  or is it the opposite?

i really do hope if someone is gonna interpret it well. thanks and more power,

michaelyuri

[stevenNYer]

Zelly:  Okay, okay, it's possible....sheesh.  Seriously, it is important ot keep in mind that there are no absolute numbers in HepB.  That's why each has to learn their own unique presentations to make sound decisions.

Michaelyuri:  I have no idea on Singapore.  Don't we have another forum member from Singapore?

[michaelyuri]

Is hepa b a ground for unemployment in singapore? I mean is hepa b one of the constraints in applying for a job in singapore? I really appreciate if someone would answer this one. someone who is knowledgeable enough about governemtn regulations in singapore with regards to hepa b in relation to employment.

[zellyf]

Its possible Steven.  By the time I was diagnosed at 27/28 I was eAg- and eAb+.  A lot of genotype Bs undergo earlier seroconversion.

[stevenNYer]

Are you sure your:
HBeAg is nonreactive
HBeAB reactive

I would retest this.  Because you are a little young to go through this conversion process at 28.  It could be that HBeAg and HBeAB are flip flopping if you are in the middle of this conversion process.  

If it's correct than, the virus escape the eSeroconversion process by mutating.  If this is the case, then you would likely need a lifetime of treatment and doing it with LAM alone is not a good idea.  You may need decades of treatment so you need long term planning for the resistance issue.

[michaelyuri]

Well, I am a filipino and i am 28 years old.

[stevenNYer]

What's your ethnic background?  Age?  Gender?

If you are eAntigen Non Reactive and eAntibidy Reactive with a high viral load, you may need a lifetime of treatment.  So resistance will be a concern.  If your doctor wants to treat with LAM only until resistance to LAM is detected, it's a bad plan.

Given your viral load is NOT THAT high yet.  The minimum I would ask for is combo with LAM and Adefovir.  You will improve your resistance profile a great deal.  As Zelly pointed out just LAM treatment is no longer recommended.  If you could get Entecavir and / or Tenofovir, it's even better.  It's likely you have to think long term.

Now, I'm no doctor, but I would discuss the above with your doctor.