Aa
2nd round HCV treatment
Okie-Dokie;
It took me 6 months to get this together, but I've finally got the 2nd round of Tx going again. Here is a brief overview of round 1:
51 year old Caucasian male
Genotype 1a
Grade 2, stage 3/4
254 lbs
Diabetes M. type 2
Dx with HCV 12/04
Treated with Pegasys/ Copegus total 56 weeks, from 2/05 through 3/06.
Slow viral response at 12 week assay, so increased riba from assigned 1200 mg/day to 1800 mg/day.
Became undetectable to <50 IU by week 20.
Relapsed within 30 days post Tx.
I started round 2 on 9/15/06 with Peg-Intron 0.50 mL/150 mcg/week, and ribavirin 2000 mg/day. For the first three injections, I've been drawing up the entire contents of the IFN vial, after reconstituting with 0.70 mL of the supplied diluent. This has given me an extrapolated dosage of 202 mcg Peg-Intron/week, based on a 0.68 mL injection. Although this IFN dosage isn't officially sanctioned by my new doctor, I have an appointment this Tuesday, and I'll disclose at that time. My three-week labs should be available for review by then, and hopefully will show some positive trends; if not, there's always dose reduction... :-).
Subjectively, I feel fine after three injections; no side effects have shown themselves yet, however this is still *way* early in the game. Last treatment, I was good until week 9 or 10 before this cr@p started creeping up on me, so I guess time will tell the story.
It's probably worth mentioning that I've made some changes regarding exercise and diet as well. As a diabetic, it's important that I maintain tight blood glucose control- particularly while on treatment. Over the last six months, I've managed to lose approx. 50 lbs; walking 8 miles daily in the hills here along with removing most processed foods as well as meats (salmon only now!) from my meals has been really helpful. More and more evidence is suggesting that obesity and insulin resistance are both negative prognostic indicators for SVR, so we'll see if this has any effect in the long run.
I don't expect to be posting very actively; however that just might change if these meds begin slowing me down. Until then, I'm trying to stay as active as possible. I think attitude is an effective tool for Sx; during my last treatment, I resigned myself to the fact that I'd get sick from these meds. This time, I'm going to keep going until I get Gumby-Legs and can't walk... In other words, if the side-effects knock the door off the hinges, I guess they're coming in; however, I'm not going to wait around for them.
My very best to all those folks that I recognize from days past, in addition to a whole lot of new ones as well. Keep plugging away at this stuff, and we'll eventually prevail--
Bill
It took me 6 months to get this together, but I've finally got the 2nd round of Tx going again. Here is a brief overview of round 1:
51 year old Caucasian male
Genotype 1a
Grade 2, stage 3/4
254 lbs
Diabetes M. type 2
Dx with HCV 12/04
Treated with Pegasys/ Copegus total 56 weeks, from 2/05 through 3/06.
Slow viral response at 12 week assay, so increased riba from assigned 1200 mg/day to 1800 mg/day.
Became undetectable to <50 IU by week 20.
Relapsed within 30 days post Tx.
I started round 2 on 9/15/06 with Peg-Intron 0.50 mL/150 mcg/week, and ribavirin 2000 mg/day. For the first three injections, I've been drawing up the entire contents of the IFN vial, after reconstituting with 0.70 mL of the supplied diluent. This has given me an extrapolated dosage of 202 mcg Peg-Intron/week, based on a 0.68 mL injection. Although this IFN dosage isn't officially sanctioned by my new doctor, I have an appointment this Tuesday, and I'll disclose at that time. My three-week labs should be available for review by then, and hopefully will show some positive trends; if not, there's always dose reduction... :-).
Subjectively, I feel fine after three injections; no side effects have shown themselves yet, however this is still *way* early in the game. Last treatment, I was good until week 9 or 10 before this cr@p started creeping up on me, so I guess time will tell the story.
It's probably worth mentioning that I've made some changes regarding exercise and diet as well. As a diabetic, it's important that I maintain tight blood glucose control- particularly while on treatment. Over the last six months, I've managed to lose approx. 50 lbs; walking 8 miles daily in the hills here along with removing most processed foods as well as meats (salmon only now!) from my meals has been really helpful. More and more evidence is suggesting that obesity and insulin resistance are both negative prognostic indicators for SVR, so we'll see if this has any effect in the long run.
I don't expect to be posting very actively; however that just might change if these meds begin slowing me down. Until then, I'm trying to stay as active as possible. I think attitude is an effective tool for Sx; during my last treatment, I resigned myself to the fact that I'd get sick from these meds. This time, I'm going to keep going until I get Gumby-Legs and can't walk... In other words, if the side-effects knock the door off the hinges, I guess they're coming in; however, I'm not going to wait around for them.
My very best to all those folks that I recognize from days past, in addition to a whole lot of new ones as well. Keep plugging away at this stuff, and we'll eventually prevail--
Bill
I just got the calender out yesterday and I started on 2.10.2006, but went undetectible on 7.27.2006, so I am counting 36 weeks past that day....long roe ahead of us, hey?
Glad you got the plan lined out. I am duly impressed - walking 8 miles a day in the hills no less and changing your diet dramatically. Wow. I can tell you are determined that this will work this time.
2000 riba should sure do the trick. If it doesn't I wonder if any amount would.
Best to you - I will look for your posts.
kathy
2000 riba should sure do the trick. If it doesn't I wonder if any amount would.
Best to you - I will look for your posts.
kathy
I dont mean to take your hopes down or anything but to be honest part of your failure lies in your weight.Treating at that weight is huge factor in your treatment failing the first time.How do i know because i also treated at the same weight as you and failed.i did my research and found out the majority of overweight patients on treatment fail.Retreating now with nothing changing in your current physical condition will show no changes at the end of this treatment but loss of motivation.you must prepare your body for it.Exercise expand the veins,increase heart rate,increase protein to repair the livers damage from the virus,and remove the fat from the midsection so the pegasys can circulate.You will notice at that weight as i did the interferon almost seems non existent cause the weight is so high.its trapped in the fat.
I am preparing for my next treatment but not till i get my weight down.I am now at 210 from 250 and will retreat at 190.I would prefer to be at 180 but i dont think at my current weight loss i would hit that for quite a while.
I have cirrosis and have been working out 4 months now and have lost 40 pounds.Working out mon,wed,fri with weights and 10 minutes of cardio at end of weight training.If i have the energy i do cardio for 30 minutes on tues and thurs.Low impact since my joints hurt me alot from being overweight for so many years.I eat 4 small meals a day.
I eat 4 egg whites and one whole egg in morning with ketchep mixed with 1/3 cup oatmeal.
Then to gym.
After gym banana 1 teaspoon peanut butter,and chicken or oatmeal again.and yes it tastes horrible,but i want to succed at treatment this time.
supper my wife makes roast beef,more chicken,or steak.
For my last meal i eat yogurt 1 more teaspoon peanut butter and almonds or pecans,or my fav snack grape tomatoes.
I have one junk day a week on sundays i eat ice cream,cookies whatever i want to relieve my cravings then back on track from mon to sat dedicated.
I am keeping a photo journel of my changes i will post it once my goals are achieved once a month i take front and side photos of myself.I have noticed since i have been working out i have required my sleep for my liver to repair and keep with the virus.i try for 10 hours a night.
anyways if you decide to go for it now good luck.But i suggest taking 30 pounds or more of fat away first.Then you can be confident things have changed this time for success.
I am preparing for my next treatment but not till i get my weight down.I am now at 210 from 250 and will retreat at 190.I would prefer to be at 180 but i dont think at my current weight loss i would hit that for quite a while.
I have cirrosis and have been working out 4 months now and have lost 40 pounds.Working out mon,wed,fri with weights and 10 minutes of cardio at end of weight training.If i have the energy i do cardio for 30 minutes on tues and thurs.Low impact since my joints hurt me alot from being overweight for so many years.I eat 4 small meals a day.
I eat 4 egg whites and one whole egg in morning with ketchep mixed with 1/3 cup oatmeal.
Then to gym.
After gym banana 1 teaspoon peanut butter,and chicken or oatmeal again.and yes it tastes horrible,but i want to succed at treatment this time.
supper my wife makes roast beef,more chicken,or steak.
For my last meal i eat yogurt 1 more teaspoon peanut butter and almonds or pecans,or my fav snack grape tomatoes.
I have one junk day a week on sundays i eat ice cream,cookies whatever i want to relieve my cravings then back on track from mon to sat dedicated.
I am keeping a photo journel of my changes i will post it once my goals are achieved once a month i take front and side photos of myself.I have noticed since i have been working out i have required my sleep for my liver to repair and keep with the virus.i try for 10 hours a night.
anyways if you decide to go for it now good luck.But i suggest taking 30 pounds or more of fat away first.Then you can be confident things have changed this time for success.
just noticed my bad you mentioned you have already lost 50 pounds you are right on track.awsome i see success in your future with this treatment.
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