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7977 and Ribavirin
Has anyone gone through the HCV clinical trial with 7977 and Ribavirin for 12 weeks? RU undetectable?
I am not onr to usually post, but I have been on this therepy since August 28. I am gett the actual drug, no placebo and no needles, I was all in.
My first week was just blood work and test.
The second week my VL was 650M
The third week was 47
The forth week was 25
The fifth week was UND
and I have been UND since.
I am high on the UCSF transplant list and they wanted to give me a better chance to get a clean liver.
I have had a couple of side affects
only one has been a pain, it is a dry cough. I tried the Peg therapy a few years back and those side effect and the having to use a needle was a real pain. I got to 24 weeks but my VL would not drop.
I think this may be a good thing, keep our fingers crossed.
My first week was just blood work and test.
The second week my VL was 650M
The third week was 47
The forth week was 25
The fifth week was UND
and I have been UND since.
I am high on the UCSF transplant list and they wanted to give me a better chance to get a clean liver.
I have had a couple of side affects
only one has been a pain, it is a dry cough. I tried the Peg therapy a few years back and those side effect and the having to use a needle was a real pain. I got to 24 weeks but my VL would not drop.
I think this may be a good thing, keep our fingers crossed.
So Awesome. I am UND at 4 weeks post treatment. I will have the 12 week test on Oct. 1 but I just had blood drawn for my own viral load. I asked PCP if he'd write the scrip and he did. It will be 9 weeks. I just need to see it myself in black and white. At 12 weeks I'll feel more secure but not really till week 24 and then I'll run my own again. One crazy thing though, after I had the blood draw today I had an anxiety attach worrying did the nurse use a dirty needle and reinfect me. Nuts, right? It was quest lab how silly of me. Anyway. I too am grateful and I had virtually no sides either except I was a mess emotionally. Felt angry. Now that it's over I don't feel that way anymore. That's how I know it was that.
Sorry I missed your posts the last few days.
I finished on 8/30/12. I do feel much better. I have a little cough from the riba but really nothing else.
I do have some arthritis in my hip which I believe started while on triple tx last year. It was listed as a possible sx if you were prone to get it later on anyway. I've worked outside for 40 years so I imagine I was gonna get it sooner or later. i just wish it was later.
I hope you feel better in time. Good luck.
I finished on 8/30/12. I do feel much better. I have a little cough from the riba but really nothing else.
I do have some arthritis in my hip which I believe started while on triple tx last year. It was listed as a possible sx if you were prone to get it later on anyway. I've worked outside for 40 years so I imagine I was gonna get it sooner or later. i just wish it was later.
I hope you feel better in time. Good luck.
Just got 12 weeks end of treatment results.UND. Have been UND at or before day 7. Little sides. So very grateful!
Hi, I was looking for info. on your trial- were you on 7797 and Ribavirin?
I would think 3 months after end of treatment. you wouldn't have any more sx.
It is nearly a week and I am beginning to feel good. Initially, after tx I had daily headaches but they seem to have faded out.
Very sorry to hear about the patient who relapsed. S/he was geno 3 and was on 7797 and ribavirin for 12 weeks?
Hope you feel better soon.
I would think 3 months after end of treatment. you wouldn't have any more sx.
It is nearly a week and I am beginning to feel good. Initially, after tx I had daily headaches but they seem to have faded out.
Very sorry to hear about the patient who relapsed. S/he was geno 3 and was on 7797 and ribavirin for 12 weeks?
Hope you feel better soon.
That is wonderful. This morning I just heard from my study that I am undetectable at 4 weeks after the end of the meds, therefore I was directed to go on to week 12 of the study when they will again draw my blood. They will not unblind it until Jan, week 24 so technically I am not going to be told straight out of the results until then but those who are not undetectable are being sent to a study registry. Oh, one thing, it is not a 100% cure for type 2 and 3. I just found out today that sadly, one of the other patients is now detectable and is being sent to the study registry. I feel so bad for that patient but happily, they will be offered the next promising med.
I was told it would be available at the end of next year. But I don't have any inside information, just what my Doc tells me.
No, it was the Quantum study. It started out where I was taking PS938 and 7797 or placebo. I was actually on 938 and cleared within the week, but they halted the study due to toxic reactions from may folks on 938. I had been on it and a placebo for barely 4 weeks.
That entitled me to the rollover when I relapsed which was to use the most effective combination available. Being gen 2, 7797 and Ribavirin had a 100% cure rate so that is what I ended up on, as did most of the others in my same study. All, but the one are doing great.
That entitled me to the rollover when I relapsed which was to use the most effective combination available. Being gen 2, 7797 and Ribavirin had a 100% cure rate so that is what I ended up on, as did most of the others in my same study. All, but the one are doing great.
Any Idea when the drug will be approved for use for hep c doctors to prescribe. Iam GT 1a with some fibrosis.
Oh, forgot to say, they want to find out the least amount of time it takes to cure because the medicine is unbelievably expensive. eg. 12 weeks of 7977 and Ribavirin is $90,000 if we had to pay for it.
Forgot to mention, I wish that I had been on that study that you were on. I wish you the best of luck and I really believe you are in the clear!!!
Oh, I wish you luck so much. I just finished the 7977 and Ribavirin July 9. It is double blind so no one will know if they are und until January. One thing that scares me though, my ALT was very low from week 2 on which is good and when I finished the drug it was 15 but then went up to 22 4 weeks after the end of the meds. I am worried because you'd think it would have stayed put. I know it's just 7 points but why would it go up at all? So, because it doesn't say anywhere that we can't run our own viral load, I just went for the blood test today. I will have been finished with the medicine 8 weeks. I don't feel any better. do you feel better? I didn't have alot of Hep C symptoms but have the joint pains etc. Not sure what it is from. How do you feel?
which study were you on? I don't know of any that has just the 7977 and ribavirin for 24 weeks. Could it be that you mean a different drug?
I just looked it up and made sure I had the latest study. Here is the correct website for a clinical trial for 7977and ribavirin. Hope this helps. http://clinicaltrials.gov/ct2/show/NCT01625338
no, only for clinical trials for now. Here is the website where you can check out open clinical trials. http://www.clinicaltrials.gov/ct2/results?recr=Open&cond=HCV&intr=7977+and+Ribavirin
I just finished 24 weeks w, 7797 and Ribavirin. I was undetected at 4 weeks. The Dr. wanted me to do 24 weeks because I have cirrhosis. He said only one person in their study (of around 40) has relapsed. Geno 1 and cirrhotic and had tx for 12 weeks.
I don't know why they bother with 12 weeks for orals since the sx aren't impossible and it seems to give better odds to treat longer than not.
I don't know why they bother with 12 weeks for orals since the sx aren't impossible and it seems to give better odds to treat longer than not.
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GT1a, Stage 2 level 2, VL 3.5mil.
Triple tx failure.
We were supposed to do 12 weeks but they extended us to 24.
I had a little cough from the riba but no other sx. Unbelievable drug.
I have been UND since day 14.