Found this a few weeks back and don't remember anyone posting it. This may hold some , if only a little, hope for those not able to tolerate SOC at all. jerry
-- Data from a poster presentation, "Randomized, Double-Blind Placebo-
Controlled Trial of Nitazoxanide in the Treatment of Patients with
Chronic Hepatitis C Genotype 4" showed that nitazoxanide monotherapy
for 24 weeks did not produce adverse events significantly different
from that of a placebo and suggest that monotherapy with nitazoxanide
may be effective in achieving SVR in a limited subset of patients with
low viral load.
In this randomized, controlled study, 50 treatment-naïve patients with
chronic hepatitis C genotype 4 were randomized to receive one
nitazoxanide 500 mg tablet or a matching placebo tablet twice daily for 24 weeks. Baseline viral loads and other disease characteristics were similar between groups. Seven of 23 patients (34%) receiving
nitazoxanide monotherapy achieved undetectable serum HCV RNA after 24
weeks of therapy, compared with 0 of 24 patients receiving placebo
P=0.004). Four of these 7 treatment responders (4/23, or 17%) had a
SVR 24 weeks after completion of therapy. Patients not achieving
undetectable HCV RNA did not show significant reductions in viral load
or alanine aminotransferase (ALT) levels. Patients responding to
nitazoxanide treatment had lower viral loads at baseline. Adverse
events were typically mild to moderate and occurred with similar
frequency and severity between the nitazoxanide and placebo groups.
"The study demonstrated the safety of long-term nitazoxanide exposure
in patients with chronic hepatitis C. Importantly, this data suggests that
thiazolides have an interferon-like mechanism and as a class may have a
role as single agent therapy in some patients," said Dr. Emmet Keeffe,
chief medical officer for Romark and co-author of the study.
http://www.hepcaustralia.com.au/index.php/component/content/article/24-latest-news/611-romark-announces-presentation-of-new-data-for-nitazoxanide-in-chronic-hepatitis-c-at-easl-2008