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3242225 tn?1348336521

Anyone want to see a great article?

http://www.natap.org/2012/HCV/072712_01.htm
Here is a summary of what Gilead is doing in it's atempt to get 7977 to market but in addition, it's attempt to go for the holy grail of creating a once a day pill for all genotypes.  They say in this article that they are very close. I believe them. I'm been involved in one of their clinical trials and this company literally brings tears to my eyes in how ethical and just plain decent they are in the way that they are treating patients.  so, here's a good one to give everyone the hope that a side effect free once a day pill is coming that can cure all genotypes.  It's coming..
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Avatar universal
I was probably the initial person that cried foul when Gilead decided not to partner with BMS. However, I now see the bigger picture. Gilead are in fact combining 7977 with 5885 (their own NS5a) into one pill and the next trial will have it. I definitely see the reason for them wanting only one pill. If one pill can get to market, it's going to make eradicating this virus, that much easier. People can remember to take ONE pill, as opposed to several. 7977 is in phase 3 and 5885 has been around for a good while now. They actually know a lot about it and it's comparable to BMS' NS5a.
I don't understand anyone saying it's put the cure back ten years! Gilead will be filing for FDA approval next year for 7977+riba for geno's 2 and 3 and look to hopefully follow that up in 2014 for geno 1's with 7977+5885.
What does one mean that they'll stop research? When you have the cure, you have the cure! Gilead have never stopped research with HIV. In fact they're the leading pharma in that department and I would say that the world should be very happy about that. Personally, I'm feeling very good about what they have to offer.
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3242225 tn?1348336521
Thank you, Ukgirl55.  You know I just want to share something else having just gone through their 7977 and riba and now am UND at 4 weeks and we'll see.  I kinda fell in love with the company when I was first learning about them and waiting to get enrolled in the clinical trial  Reason is, they said that those who got on placebo would without exception receive the real medicine once the study was completed.  I thought that very humane and wonderful.  Now I just saw them act so wonderfully again.  Unfortunately one man in the study that I am in relapsed after completion of the study when blood was taken at 4 weeks post and Gilead pulled him and had him sign up for the study registry.  That registry is for all of their patients who relapse and they will be first in line when another treatment becomes available.  The study design is such that it says that they will not unblind it until 24 weeks post, and yet rather than let this poor man believe that he maybe was cured, they pulled him and put him in the registry now and reassured him that he would be in line for the next treatment for sure.  What they did by doing that was blow their whole cover on the double blind because the rest of us know that we are UND or they would have pulled us too.  But they did it anyway because they didn't want this guy to hope for another 20 weeks only to have him be relapsed at the end.  I call that a fine company with a conscience.  
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3242225 tn?1348336521
Thank you, Hector.  I feel sad for those who so want a cure to come to them and not have to go through the torture of interferon. I know it's coming.  I know that Gilead is working very hard to make it happen. They are literally betting 11 billion on it.  
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3242225 tn?1348336521
Oh, I forgot to tell you. Gilead is only testing 7977 with interferon because their goal is to eliminate interferon totally and have an all oral once a day pill for all genotypes. In order to do that, they must test 7977 and riba against interferon and riba and 7977 and interferon so that they can demonstrate that just the 7977 and riba is more effective and so much more humane than interferon.  Do you get what I mean? Just look at the clinical trials that they have done even recently and you will see it.  Hey, Odin, I agree it appears that they have done something not very nice, but they might just be working on something that is the answer to it all.  I know it is their wish.
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3242225 tn?1348336521
Yeah, I really hope that you are right.  It definitely makes sense to me.  And check this out:  http://www.ncbi.nlm.nih.gov/pubmed/22314425
And it's all about Geno. 1.  
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Avatar universal
i just finished treating with incevik.  at the end-of-treatment talk the doc told me that if i relapsed, all is not lost because they will have the next drug for me to try in about 18 months - 7977.   agree with OH - me thinks that is a little optimistic. i recall in 2007 when the president of Vertex, said incevik would be approved in 2009. so i waited - 2 years turned into 4.  hope i am wrong about 7977, and that i can try again in 18 months if i relapse. i don't begrudge big pharma their due for the investments they make.  
blessing to all,
eric
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