Aa
Dangers of Alpha Lipoic Acid IV Therapy !
Here is just one of the many dangers of ALA IV therapy:
This is from Pubmed which is considered to be very trustworthy by the medical community.
http://www.ncbi.nlm.nih.gov/pubmed/19616616
"We conclude that large doses of lipoic acid displace sulfhydryls from binding sites, resulting in depletion of serum cysteine, but also pose a methylation burden with severe depletion of liver S-adenosylmethionine and massive release of S-adenosylhomocysteine. These changes may have previously unrecognized deleterious (harmful) effects that should be investigated in both human disease and experimental models"
This is from Pubmed which is considered to be very trustworthy by the medical community.
http://www.ncbi.nlm.nih.gov/pubmed/19616616
"We conclude that large doses of lipoic acid displace sulfhydryls from binding sites, resulting in depletion of serum cysteine, but also pose a methylation burden with severe depletion of liver S-adenosylmethionine and massive release of S-adenosylhomocysteine. These changes may have previously unrecognized deleterious (harmful) effects that should be investigated in both human disease and experimental models"
Thanks B - however:
My three blood tests were all the Ash (not the NASH) Fibrosure - I did take the Ash Fibrosure test that is specific to alcoholic liver disease/ALD. I do also remember these:
INR is 1.1 - normal.
Albumin is 4.5 g/dl - normal.
Total Bilirubin is 0.6. - normal.
GGT is 31- normal.
Fasting Glucose - 80 - normal.
I'll locate my creatine and other test numbers and P.M. them to you.
My alcohol intake escalated to approx 8-10 fl oz of 80-proof liquor daily during the last 2-3 yrs of my drinking career. Certainly enough to wreak havoc on an already scarred liver
BTW I do recall that my A2M and Haptoglobin were both a bit deranged...as was my APO-A1. Funny that you asked specifically about those first two...was there a reason??!
My three blood tests were all the Ash (not the NASH) Fibrosure - I did take the Ash Fibrosure test that is specific to alcoholic liver disease/ALD. I do also remember these:
INR is 1.1 - normal.
Albumin is 4.5 g/dl - normal.
Total Bilirubin is 0.6. - normal.
GGT is 31- normal.
Fasting Glucose - 80 - normal.
I'll locate my creatine and other test numbers and P.M. them to you.
My alcohol intake escalated to approx 8-10 fl oz of 80-proof liquor daily during the last 2-3 yrs of my drinking career. Certainly enough to wreak havoc on an already scarred liver
BTW I do recall that my A2M and Haptoglobin were both a bit deranged...as was my APO-A1. Funny that you asked specifically about those first two...was there a reason??!
" and I only went downhill from there due to drinking. "
How much were you drinking ?
How much were you drinking ?
ok , than I have cirrhosis too....because I ran the FibroSure before tx
and 1 year after and it came back F4 - cirrhosis. BTW my platelets
are like yours in the 200s.
The only problems is that I have been seeing Dr. Douglas Dietrich Prof.
of Medicine @ Mt. Sinai several times before and after tx. I had approx.
6 FibrosScans done there in the course of 3 years.Diagnosis F0-F1.
I showed them the FibroSure bloodmarker test and the responds was the test was no good. I have very little to no fibrosis and should enjoy life and I can drink alcohol in moderation....Dr`s orders.
They see patients coming in frequently with results from that test that are false. Mt. Sinai is a transplant center and they should know what they are talking about.
BTW what is your INR or Protime and Albumin ?
Also I am curious as to which values on your fibrosure were out of
normal range. Was it haptoglobin and alpha2macroglobulins or GGT etc?
You did the NASH-fibrosure for non-alcoholic liver disease maybe you should try the one for alcoholic liver disease ASH-fibrosure ...lol
b
and 1 year after and it came back F4 - cirrhosis. BTW my platelets
are like yours in the 200s.
The only problems is that I have been seeing Dr. Douglas Dietrich Prof.
of Medicine @ Mt. Sinai several times before and after tx. I had approx.
6 FibrosScans done there in the course of 3 years.Diagnosis F0-F1.
I showed them the FibroSure bloodmarker test and the responds was the test was no good. I have very little to no fibrosis and should enjoy life and I can drink alcohol in moderation....Dr`s orders.
They see patients coming in frequently with results from that test that are false. Mt. Sinai is a transplant center and they should know what they are talking about.
BTW what is your INR or Protime and Albumin ?
Also I am curious as to which values on your fibrosure were out of
normal range. Was it haptoglobin and alpha2macroglobulins or GGT etc?
You did the NASH-fibrosure for non-alcoholic liver disease maybe you should try the one for alcoholic liver disease ASH-fibrosure ...lol
b
Hey B - I always appreciate your imput.
Diagnosis this past year based upon the following:
A several yrs-old biopsy showed 'bridging fibrosis with septae' which is stage 3 extensive fibrosis...and I only went downhill from there due to drinking.
Three AshFibrosure tests during 2011-2012 scored .70, .68 and .71 - stunningly consistent results. It's a 100-pt test - anything under .25 is normal/minimal fibrosis. Anything over .70 is 95% probability of cirrhosis; anything over .74 is 100% probability. I think it's safe to say that I have SOME cirrhosis...just how extensive is unclear. Even a biopsy today (since it samples only1/50,000 of the liver) wouldn't tell us how extensive it is. Will be seeing the doc again in a couple of months.
I have palmar erythema. I have periodically cold hands due to diminished circulation in hands/fingers. Hope this helps to provice a clearer picture! I hope you're doing well these days. Any thoughts are always welcome.
Diagnosis this past year based upon the following:
A several yrs-old biopsy showed 'bridging fibrosis with septae' which is stage 3 extensive fibrosis...and I only went downhill from there due to drinking.
Three AshFibrosure tests during 2011-2012 scored .70, .68 and .71 - stunningly consistent results. It's a 100-pt test - anything under .25 is normal/minimal fibrosis. Anything over .70 is 95% probability of cirrhosis; anything over .74 is 100% probability. I think it's safe to say that I have SOME cirrhosis...just how extensive is unclear. Even a biopsy today (since it samples only1/50,000 of the liver) wouldn't tell us how extensive it is. Will be seeing the doc again in a couple of months.
I have palmar erythema. I have periodically cold hands due to diminished circulation in hands/fingers. Hope this helps to provice a clearer picture! I hope you're doing well these days. Any thoughts are always welcome.
It drives me a bit nuts that there's no edit feature! My last sentence got botched, so I will try again...
Idyllic, thanks for your input!
Regarding your first paragraph - yes, you are correct on all counts.
Other than the lab reference you gave, I've never seen one with normal adult male RBC as anything under 4.0. Here is a copy/paste:
"A normal red blood cell count will vary depending on the age and sex of the person tested. The normal number for women tends to range from about 4.2-5.4 million red blood cells per microliter (million/uL). Men have a considerably higher normal range, falling between 4.7-6 million/uL. Children tend to fall somewhere in the middle of these two, and have a very narrow normal red blood cell count range of about 4.6-4.8 million/uL"
The above certainly indicates that my current RBC of 3.8 is consistent with mild anemia. My RBC was in the 4.8 range - and then rather suddenly dropped in recent months. If you don't mind, I would be interested: what type of inaccurate diagnosis did you experience??
Idyllic, thanks for your input!
Regarding your first paragraph - yes, you are correct on all counts.
Other than the lab reference you gave, I've never seen one with normal adult male RBC as anything under 4.0. Here is a copy/paste:
"A normal red blood cell count will vary depending on the age and sex of the person tested. The normal number for women tends to range from about 4.2-5.4 million red blood cells per microliter (million/uL). Men have a considerably higher normal range, falling between 4.7-6 million/uL. Children tend to fall somewhere in the middle of these two, and have a very narrow normal red blood cell count range of about 4.6-4.8 million/uL"
The above certainly indicates that my current RBC of 3.8 is consistent with mild anemia. My RBC was in the 4.8 range - and then rather suddenly dropped in recent months. If you don't mind, I would be interested: what type of inaccurate diagnosis did you experience??
Idyllic, thanks for your input!
Regarding your first paragraph - yes, you are correct on all counts.
Other than the lab reference you gave, I've never seen one with normal adult male RBC as anything under 4.0. Here is a copy/paste:
"A normal red blood cell count will vary depending on the age and sex of the person tested. The normal number for women tends to range from about 4.2-5.4 million red blood cells per microliter (million/uL). Men have a considerably higher normal range, falling between 4.7-6 million/uL. Children tend to fall somewhere in the middle of these two, and have a very narrow normal red blood cell count range of about 4.6-4.8 million/uL"
The above certainly indicates that my current RBC of 3.8 is consistent with mild anemia. My RBC was in the 4.8 range - and then rather sud experience??denly dropped. If you don't mind, I would be interested: what type of inaccurate diagnosis did you experience??
Regarding your first paragraph - yes, you are correct on all counts.
Other than the lab reference you gave, I've never seen one with normal adult male RBC as anything under 4.0. Here is a copy/paste:
"A normal red blood cell count will vary depending on the age and sex of the person tested. The normal number for women tends to range from about 4.2-5.4 million red blood cells per microliter (million/uL). Men have a considerably higher normal range, falling between 4.7-6 million/uL. Children tend to fall somewhere in the middle of these two, and have a very narrow normal red blood cell count range of about 4.6-4.8 million/uL"
The above certainly indicates that my current RBC of 3.8 is consistent with mild anemia. My RBC was in the 4.8 range - and then rather sud experience??denly dropped. If you don't mind, I would be interested: what type of inaccurate diagnosis did you experience??
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