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Does Hep C Cause Depression?
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Does Hep C Cause Depression?

...or is it the treatment that can cause depression..
Seems like people with the virus are more prone to be depressed?
Thanks
10 Comments Post a Comment
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Avatar_f_tn
hi there and yes it can my hubby never suffered before but began to for about 2yr before we knew he had hepc the doc said then it was a common thing to happen.So before tx for hep he had a long term anti depressant because the tx get get you more depressed good luck Jules
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Avatar_f_tn
Yes, agree with cheflady... both can cause depression.
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4896357_tn?1360674504
For me it caused strange bi-polar symptoms. I would just start crying for no reason. It happened in front of a friend and it happened in front of my doctor once. I did not feel depressed but had the symptoms!
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446474_tn?1404424777
There is no studies indicating any link between clinical depression and hepatitis C. Some folks my be stressed by having the hep C infection which can lead to chronic stress that can in certain individual lead to depression but it is rare. If it were true than a large portion of the 3-4 million Americans who are infected with chronic HCV would be clinically depressed.

For anyone with clinical depression they need to have their depression managed before starting any interferon based treatment, as interferon is known to exacerbate depression in individuals with a history of depression. It can also cause depression in those who have never had a history of depression.

PEGASYS (peginterferon alfa-2a) label

"Life-threatening neuropsychiatric reactions may manifest in patients receiving therapy with PEGASYS. Depression, suicidal ideation, and suicidal attempt may occur in patients with and without previous psychiatric illness.

PEGASYS should be used with extreme caution in patients who report a
history of depression. Neuropsychiatric adverse events observed with alpha
interferon treatment include relapse of drug addiction, drug overdose,
aggressive behavior, psychoses, hallucinations, bipolar disorders and mania.

Physicians should monitor all patients for evidence of depression and other
psychiatric symptoms. Patients should be advised to report any sign or
symptom of depression or suicidal ideation to their prescribing physicians. In
severe cases, therapy should be stopped immediately and psychiatric
intervention instituted (see ADVERSE REACTIONS and DOSAGE AND
146 ADMINISTRATION)."


Cheers!
Hector
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1815939_tn?1377995399
Study Results Indicate Potential Link Between Chronic HCV, Depression

November 29, 2012

BOSTON — Patients with chronic hepatitis C may be at greater risk for depression, according to data presented at The Liver Meeting 2012.

Researchers assessed data on 15,263 adult patients collected from the National Health and Nutrition Examination Survey between 2005 and 2010. All participants had chronic hepatitis C or chronic hepatitis B; alcohol-related liver disease (ALD), defined as elevated aminotransferases and daily alcohol consumption of more than 20 g; or nonalcoholic fatty liver disease (NAFLD), defined as elevated aminotransferases without the presence of excessive alcohol consumption or other liver diseases. Depression was evaluated according to patient responses to the PHQ-9 survey.

“There have been some small studies in the past that have shown some association of depression with chronic hepatitis C, fatty liver disease and alcoholic liver disease,” Heshaam M. Mir, MD, research manager in the Liver & Obesity program at Inova Fairfax Hospital in Falls Church, Va., told Healio.com. “We wanted to see if those results translated to population-based studies.”

Heshaam M. Mir, MD

Heshaam M. Mir

Multivariate analysis indicated that chronic HCV was independently associated with depression (OR=2.87; 95% CI, 1.78-4.62), in addition to other factors, including injection drug use (OR=52.86; 95% CI, 32.87-85.03), smoking (OR=6.20; 95% CI, 1.62-23.68) and black race (OR=2.50; 95% CI, 1.50-4.18). No association was observed between depression and chronic HBV, ALD or NAFLD.

Factors associated with NAFLD included diabetes (OR=1.54; 95% CI, 1.11-2.13) and insulin resistance (OR=2.65; 95% CI, 1.98-3.55), while ALD was associated with moderate-to-heavy smoking (OR=3.64; 95% CI, 3.09-4.30) and Mexican-American ethnicity (OR=1.55; 95% CI, 1.30-1.84). Researchers also observed associations between chronic HBV and black (OR=5.09; 95% CI, 2.41-10.76) or Hispanic race (OR=4.74; 95% CI, 2.32-9.70).

“Based on the results we found, the only association [with depression] is with chronic HCV,” Mir said, noting that this cross-sectional study allowed for the attribution of associations, but not causality. “We know that the current interferon-based regimens for HCV are known to have serious side effects, including psychiatric effects. If a patient is coming in with certain disorders, like depression, it’s important to keep that in mind before starting them on an interferon-based regimen.”

http://www.healio.com/hepatology/chronic-hepatitis/news/online/%7B1f42e2ec-65d3-46ec-b2cd-a12a22a3b6ed%7D/study-results-indicate-potential-link-between-chronic-hcv-depression
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Avatar_m_tn
Thanks pooh, I knew there had been studies on this.
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4950316_tn?1394188185
My two bobs worth:
I've been thinking on this issue whilst I've been on treatment, and I have had some bleak moments, but I have never suffered from clinical depression or associated conditions,
i believe that many people who turned to injecting drugs somewhere in their lives already had problems and issues that caused pain with emotional issues never dealt with.
And as the drugs close us down, these 'issues' are never dealt with.
So, it becomes hard with the chicken and the egg syndrome. We know the egg came first, but which one, the pain or the drugs, is the chicken?
So, the drug  lifestyle can be a result of depression, the virus can also be a contributing factor, and the treatment adds to the whole.
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1815939_tn?1377995399
Most of us never used drugs and we still got clinically depressed so Depression is not all due to lifestyle and drugs.

In addition, that study took drug use into account. Even adjusting for those who used drugs, people with Hep C had a much higher incidence of Depression overall.  
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Avatar_m_tn
Good point Asle...
I think Abusers of anything,food alcohol drugs sex... can tend to have more emotional problems that lend to anxiety phobias depression and addictions. ....the virus can mentally and physically  bring someone down
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Avatar_f_tn
Does Hepatitis C cause depression?  
__________________

I think Hepatitis C is depressing.   Feeling depressed while having hepatitis C, treating hepatitis C or post treatment of hepatitis C is normal for anyone
dealing with this depressing event.   Anyone and everyone who is feeling these effects should seek help.  
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