Aa
Failed Triple Therapy w/Incivek
Hello,
Sad to say that I had a viral load increase to 3000 at week 8 on triple therapy. Trying to wrap my head around it all, but in the meantime I have been looking at the trials available in my area. I see one that seems I would be a candidate for - Sofosbuvir/ 5885 with or without riga. I am not familiar with these trials and how they work, but I emailed the contact person and my nurse. Are these the correct steps? If anyone has any other ideas, I would appreciate it!! Thanks!!
Sad to say that I had a viral load increase to 3000 at week 8 on triple therapy. Trying to wrap my head around it all, but in the meantime I have been looking at the trials available in my area. I see one that seems I would be a candidate for - Sofosbuvir/ 5885 with or without riga. I am not familiar with these trials and how they work, but I emailed the contact person and my nurse. Are these the correct steps? If anyone has any other ideas, I would appreciate it!! Thanks!!
Hi Pooh,
I am 1a, I have not had a biopsy or the IL28B test done. I am going to request the test next week when I see my doctor. MRI shows no cirrhosis and Fibrosure test shows between 2-3. But I am not sure that test is super accurate. I am going to talk to my doctor more next week about all of that too.
I am 1a, I have not had a biopsy or the IL28B test done. I am going to request the test next week when I see my doctor. MRI shows no cirrhosis and Fibrosure test shows between 2-3. But I am not sure that test is super accurate. I am going to talk to my doctor more next week about all of that too.
Just curious what Genotype subtype you are, Genotype 1a or Genotype 1b?
Also, do you know if you are (IL28B) CC, CT, or TT?
Did you have a liver biopsy prior to treatment and, if so, what stage are you, if you know.
These factors can play a role in treatment response.
Also, do you know if you are (IL28B) CC, CT, or TT?
Did you have a liver biopsy prior to treatment and, if so, what stage are you, if you know.
These factors can play a role in treatment response.
According to Can-Do's response, I was just like you. I was a partial responder. I had a 4-log drop, got my VL down to 94, before jumping back up at week 5.
Yes, my side effects from the shot were really terrible. I basically couldn't do anything for two days while I got over it. I didn't like it at all. And I'm a very healthy 39 year old (38 at the time.)
Yes, my side effects from the shot were really terrible. I basically couldn't do anything for two days while I got over it. I didn't like it at all. And I'm a very healthy 39 year old (38 at the time.)
That is the same one I am looking at. I will start the phone calls as well. A polite pest is something I can be very good at once I get determined! Thanks for the tip!
Not sure if this would be called a null or non responder as the OP did have more then a 2 log drop, on SOC it looks to be a partial responder.
It is important to know how treatment-experienced people responded to their first course of treatment, and the regimen that they were treated with, because these factors help to predict the likelihood of SVR from re-treatment. People initially treated with standard interferon, or standard interferon plus ribavirin, may achieve SVR when re-treated with pegylated interferon and ribavirin. Sometimes, HCV re-treatment trials study a mixed population of relapsers, partial responders, non-responders, and null responders, which makes it difficult to interpret the results.
Null Responder: A null responder is someone who achieves little or no decrease in hepatitis C viral load during HCV treatment. Null responders are highly unlikely to respond to re-treatment with an interferon-based regimen.
Non-responder: Often referred to as a "treatment failure," a non-responder is someone who does not have an EVR or, if they stay on treatment for 24 weeks, does not ever have a 2-log (99%) drop in hepatitis C viral load or undetectable HCV RNA during hepatitis C treatment.
Partial Responder: A partial responder is someone who experiences at least a 2-log decrease in hepatitis C viral load during HCV treatment. Partial responders are more likely to respond to re-treatment than non-responders or null responders.
Relapser: The term relapser refers to someone who has had an EVR or ETR, but whose virus rebounded after they completed HCV treatment. People who had a relapse after completing HCV treatment are more likely to achieve SVR after re-treatment than partial responders, non-responders, or null responders.
http://www.thebody.com/content/art46371.html
It is important to know how treatment-experienced people responded to their first course of treatment, and the regimen that they were treated with, because these factors help to predict the likelihood of SVR from re-treatment. People initially treated with standard interferon, or standard interferon plus ribavirin, may achieve SVR when re-treated with pegylated interferon and ribavirin. Sometimes, HCV re-treatment trials study a mixed population of relapsers, partial responders, non-responders, and null responders, which makes it difficult to interpret the results.
Null Responder: A null responder is someone who achieves little or no decrease in hepatitis C viral load during HCV treatment. Null responders are highly unlikely to respond to re-treatment with an interferon-based regimen.
Non-responder: Often referred to as a "treatment failure," a non-responder is someone who does not have an EVR or, if they stay on treatment for 24 weeks, does not ever have a 2-log (99%) drop in hepatitis C viral load or undetectable HCV RNA during hepatitis C treatment.
Partial Responder: A partial responder is someone who experiences at least a 2-log decrease in hepatitis C viral load during HCV treatment. Partial responders are more likely to respond to re-treatment than non-responders or null responders.
Relapser: The term relapser refers to someone who has had an EVR or ETR, but whose virus rebounded after they completed HCV treatment. People who had a relapse after completing HCV treatment are more likely to achieve SVR after re-treatment than partial responders, non-responders, or null responders.
http://www.thebody.com/content/art46371.html
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