Failed Triple Therapy w/Incivek

[tired2013]

Hello,

Sad to say that I had a viral load increase to 3000 at week 8 on triple therapy. Trying to wrap my head around it all, but in the meantime I have been looking at the trials available in my area.  I see one that seems I would be a candidate for - Sofosbuvir/ 5885 with or without riga. I am not familiar with these trials and how they work, but I emailed the contact person and my nurse. Are these the correct steps?  If anyone has any other ideas, I would appreciate it!!  Thanks!!

[tired2013]

Thanks Hepcat. I was told by someone else that they could not understand why I was given this test as well. BTW, I made a mistake - I thought this was on my two week labs, but it was before I even started treatment. The results were given after I started treatment and I just had the date confused with all of the other labs.  NO SVR for me - never even made und. Was taken off of everything at week 8. Starting VL was 6 million, 2 week vl was 810, 4 week vl was 610, 8 week vl was 3000. Not very many people have much info about the genosure test, but now hearing two people say that the test should not have been given this test is odd. Hopefully I can get some answers when I see my doc. Thanks again!

[hepcat1954]

Sorry realize you were partial responder.  

Retake the Genosure test again now to see if it shows you have resistant variants at this point.  There's nothing you can do but it will explain your Tx outcome.

HC

[hepcat1954]

I had the Genosure test done within a month of failing triple on Incivek.  I had double resistant variants to protease inhibitors, V36M + R155K.

It's why I failed Tx.  Starting VL = 520,000 IU/mL; week 4 = 54 IU/ml; week 8 = 127 IU/ml; week 12 = 2,636 IU/mL so treatment was then stopped.  

BTW: The virus starts out as wild type, then, if you have resistant variants, only resistants will remain after several weeks or months of Tx; then the virus morphs back to wild type ~ 12 months after Tx ends.  So I'm not sure why you were given the test 2 weeks into therapy.  The variants are probably not dominant at that point.

Did you reach SVR?  

HC

[purplecat]

My 7977/5885 consent form says "must advise all medications taken within the last 30 Days.  Some medications are not allowed and the study Doctor will discuss  these with you in detail"  Nothing about anything longer than 30 Days and doesn't really say within that period  what drugs are not allowed.  You could look into new trials if you are interested.

[cheflady]

hi im so sorry that you relapsed it must have been heartbreaking i hope you can give your body a chance to recover and that you get accepted for trials and have success. wish you all the best for the future and take care of yourself

[tired2013]

Thanks. It has been pretty hard to take, but I am hanging in there. I hope that something comes up for your husband as well.