Searching the web, I found one site that gives the normal hemoglobin ranges as:
Adult males: 14-18 gm/dl
Men after middle age: 12.4-14.9 gm/dl
According to this I am too high, with usually 16 to 17 gm/Dl.
I'm not at all happy with the idea of doing one or more phlebotomies in oreder to get into that trial, which reopens in March, but maybe I should try it if it's the only PI trial around. Like you say, dumping one or even two half-liters of blood maybe isn't a great idea with platelets down to around 125k.
I don't know what my iron is. The only thing I can find on my blood analyses is serum ferretin, which is very high (around 280 ng/mL in 2008). Saturation (whatever that means) was high, too.
Glad to hear that the anesthetic won't be heavy. I hear that anesthetics are bad for the liver.
Frankly, I hate the whole idea of it. But if it's really justified, I'll do it. What the hell, I'm already the prime guinea pig for the hospital. Might as well do 'em all.
Mike
It seems I am the hospital{s favorite guinea pig. Sometimes I wonder if it isn't a general policy used to scare me off and get rid of me. I'm not very popular there as I am always asking questions and generally being a pest. I think they unconsciously would like me to disappear, one way or an other. It's the "other" way that worries me.
M.
my best guess is it's to rule out the rare bone marrow disease that causes too many red cells to be made. Although, you are only 1 or 2 points out of normal range, so not sure what their thinking is.
It might be better to get your iron accessed...you don't want them to bleed you with your platelets being low, unless your iron is high...having a few too many HGB (red cells) is something most hcv'ers would envy.
anyway, if they are insisting, I'd consider it...they'll give you a fast acting sleeper like versed or something...you should throw it off fine...the fast acters wear off in minutes, and aren't as problematic as the stuff for long surgeries.
You said SOC won't work at 65 type 1?? You are slender, don't have to many other contraindicators, I'd say whoever told you that didn't know that many folks are successful at that age. Particularly those with good BMI index and no IR. The other thing to consider is if you could SVR, you'd stop the slippery slope now. How high are your Alt's? What your iron at?
I have seen honest-to-god guinea pigs that get fewer intrusive tests and procedures than you seem to be getting in BA. Are you the only test animal they have in SA? :-)
Best wishes on your decision. Hope it all comes out OK (no pun intended). Hang in there
Brent
Hey, Brent, how's it going? It's been a while. Hope you are copasetic. How's life on immuno-suppression? Must be a barrel of laughs, huh? (Just kidding of course. My usual perverse sense of humor.)
If farting is the worst consequence of having the GB removed, I'm safe. I fart so much already that no one would notice the difference.
As usual around here in B.A., there are gonna be as many different opinions between doctors on whether or not to remove my GB and when, as there are on when and how to do Tx. Which is the main reason I tend to do nothing: too many choices, not enough facts.
I sorta liked Dr. Frider's argument about not waiting until it's too late. I lean towards the preventive medicine side of things. But there's always that "Don't fix it if it isn't broken" refrain whispering to me from the past. It's one of those damned if you do, damned if you don't situations. I know I don't have to explain that one, right?
Anyway, it isn't happening tomorrow. And now I've got a more pressing worry: this bone marrow puncture they want to do on me. If it ain't one thing it's another. Never a dull moment. Isn't life weird?
M.
Are you pretty confident they're going to approve Telaprevir soon? It would be worth waiting for. But I've read and heard the opinion expressed by several hepatologists that the USG isn't going to approve it, at least not right away. Too many demographic concerns, like creating more virulent escape variants in the population.
I'd sure like to have an inside man at the FDA. But then I guess so would all the folks with Vertex shares [grin].
M.