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High Uric Acid Levels
I've had High uric acid Levels before Tx and while Txing... I'm having problems with my back it might be Kidney stones.. I'm going to get an Ultrasound to make sure... Is the high uric acid level the cause of my back pain??
How can i lower these levels?? The pain is in the right side kidney area... If it is kidney stones what do i do?? The study nurse might tell me to stop Tx... and i dont want this to happen.. Please help!! thank you!!
TippyClubb funny you mention high uric acid levels!!!
How can i lower these levels?? The pain is in the right side kidney area... If it is kidney stones what do i do?? The study nurse might tell me to stop Tx... and i dont want this to happen.. Please help!! thank you!!
TippyClubb funny you mention high uric acid levels!!!
"I mentioned it because my uric acid is high 8.5 and it started out in normal range. Trial nurse is not worried "
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She should be. Because a uric acid higher than 5.8 is predictive of poor response to Hep C treatment.
"she said it can get into the 30's before they are concerned."
------------------------------
That means she's letting people fail tx. Make a copy of the study and give it to her (and another to the doctor).
(J Med Virol. 2008 Apr;)
"Is serum uric acid a predictive factor of response to IFN-treatment in patients with chronic hepatitis C infection?"
Pellicano R, Puglisi G, Ciancio A, Balzola F, Saracco G, Ciccone G, Baldi I, Abate ML, Smedile A, Rizzetto M. Department of Gastro-Hepatology, San Giovanni Battista (Molinette) Hospital, Torino, Italy.
Several factors, including metabolic profile, are predictive of response to standard antiviral therapy in patients with chronic hepatitis C. In a retrospective study, it was investigated whether uric acid, involved in metabolic syndrome, could be included. A total of 153 patients (56.2% males; mean age 45.7 +/- 11.3 years) treated with pegylated-interferon and ribavirin were included. Eighty-five were infected with hepatitis C virus (HCV) genotype 1 or 4 and 68 with genotype 2 or 3. Viral load was >1,000,000 IU/ml in 101, < or =1,000,000 IU/ml in 35 and unknown in 17 patients. Ishak fibrosis score was 4 in 15 and unknown in 57 patients. Mean serum uric acid was 5.05 +/- 1.3 mg/dl. Sustained virological response (negative serum HCV-RNA 6 months after treatment cessation) was achieved in 102 patients (67%). In the final logistic model, serum uric acid level > or =5.8 mg/dl (OR = 0.46; 95% CI: 0.30-0.62), viral load (OR = 0.29; 95% CI: 0.09-0.92) and HCV genotype (OR = 0.23; 95% CI: 0.09-0.60) were identified as the most important factors independently influencing clinical outcome. The prognostic role of serum uric acid was confirmed on the sub-sample reporting Ishak fibrosis score (OR = 0.49; 95% CI: 0.28-0.85). SERUM URIC ACID
LEVEL > or =5.8 mg/dl IS PREDICTIVE OF POOR RESPONSE TO HCV TREATMENT. Prospective studies are needed to clarify the issue.
http://www.ncbi.nlm.nih.gov/pubmed/18297716?ordinalpos=118&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
"I stated to drink lots of Cranberry juice and that seemed to help, but not really sure. I know one thing the Cran juice wont hurt you."
------------------------------
Worst thing you can do. High uric acid is associated with insulin resistance and hyperinsulinemia (see my previous post to BklynBoy). And juice is loaded with sugar. So you're making it worse.
Co
------------------------------
She should be. Because a uric acid higher than 5.8 is predictive of poor response to Hep C treatment.
"she said it can get into the 30's before they are concerned."
------------------------------
That means she's letting people fail tx. Make a copy of the study and give it to her (and another to the doctor).
(J Med Virol. 2008 Apr;)
"Is serum uric acid a predictive factor of response to IFN-treatment in patients with chronic hepatitis C infection?"
Pellicano R, Puglisi G, Ciancio A, Balzola F, Saracco G, Ciccone G, Baldi I, Abate ML, Smedile A, Rizzetto M. Department of Gastro-Hepatology, San Giovanni Battista (Molinette) Hospital, Torino, Italy.
Several factors, including metabolic profile, are predictive of response to standard antiviral therapy in patients with chronic hepatitis C. In a retrospective study, it was investigated whether uric acid, involved in metabolic syndrome, could be included. A total of 153 patients (56.2% males; mean age 45.7 +/- 11.3 years) treated with pegylated-interferon and ribavirin were included. Eighty-five were infected with hepatitis C virus (HCV) genotype 1 or 4 and 68 with genotype 2 or 3. Viral load was >1,000,000 IU/ml in 101, < or =1,000,000 IU/ml in 35 and unknown in 17 patients. Ishak fibrosis score was 4 in 15 and unknown in 57 patients. Mean serum uric acid was 5.05 +/- 1.3 mg/dl. Sustained virological response (negative serum HCV-RNA 6 months after treatment cessation) was achieved in 102 patients (67%). In the final logistic model, serum uric acid level > or =5.8 mg/dl (OR = 0.46; 95% CI: 0.30-0.62), viral load (OR = 0.29; 95% CI: 0.09-0.92) and HCV genotype (OR = 0.23; 95% CI: 0.09-0.60) were identified as the most important factors independently influencing clinical outcome. The prognostic role of serum uric acid was confirmed on the sub-sample reporting Ishak fibrosis score (OR = 0.49; 95% CI: 0.28-0.85). SERUM URIC ACID
LEVEL > or =5.8 mg/dl IS PREDICTIVE OF POOR RESPONSE TO HCV TREATMENT. Prospective studies are needed to clarify the issue.
http://www.ncbi.nlm.nih.gov/pubmed/18297716?ordinalpos=118&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
"I stated to drink lots of Cranberry juice and that seemed to help, but not really sure. I know one thing the Cran juice wont hurt you."
------------------------------
Worst thing you can do. High uric acid is associated with insulin resistance and hyperinsulinemia (see my previous post to BklynBoy). And juice is loaded with sugar. So you're making it worse.
Co
"I've had High uric acid Levels before Tx and while Txing... I'm having problems with my back it might be Kidney stones.. I'm going to get an Ultrasound to make sure... "
----------------------
I told you that you needed to get checked for insulin resistance. High uric acid is associated with having insulin resistance and hyperinsulinemia.
"In the present study, URIC ACID had an independent, significant association with metabolic syndrome in different logistic analyses, SHOWING A CONSISTENT RELATION TO INSULIN RESISTANCE. Uric acid actually correlated significantly with the fasting and two-hour insulin levels (r = 0.34). These findings are in agreement with the previous studies, in which uric acid has been connected with insulin resistance as measured with the euglycemic clamp technique or the insulin suppression test (Modan et al. 1987, Facchini et al. 1991, Vuorinen-Markkola & Yki-Järvinen 1994). This relationship persisted when the differences in age, sex, overall obesity and abdominal obesity were taken into account. Facchini et al. found (1991) that URINARY URIC ACID CLEARANCE DECREASES IN PROPORTION TO INCREASES IN INSULIN RESISTANCE in normal volunteers, leading to an increase in the serum uric acid concentration. The mechanism explaining the observed association is unclear. On the one hand, there are mechanisms implying DECREASED RENAL EXCRETION OF URIC ACID IN THE PRESENCE OF HYPERINSULINEMIA, including increased levels of ketoacids and increased sodium reabsorption with the elevation of uric acid (Modan et al. 1987). On the other hand, there are mechanisms associated with increased production of uric acid. Uric acid is a purine base that may originate from turnover and degradation of various phosphate nucleosides, such as ATP, or dinucleotides. Increased ATP turnover has, in turn, been shown to explain hyperuricemia induced by ethanol, acetate and fructose." (Vuorinen-Markkola & Yki-Järvinen 1994).
---------
"Is the high uric acid level the cause of my back pain?? "
---------------------
Since there's decreased excretion of uric acid by the kidneys, that's probably what's causing the pain.
"How can i lower these levels?? "
---------------------
There is medication that can lower the uric acid. But you need to also take care of what's CAUSING the high uric acid. In other words, you need to do something about the insulin resistance.....because having high uric acid levels IS PREDICTIVE OF POOR RESPONSE TO Hep C treatment!!!
Co
(J Med Virol. 2008 Apr;)
"Is serum uric acid a predictive factor of response to IFN-treatment in patients with chronic hepatitis C infection?"
Pellicano R, Puglisi G, Ciancio A, Balzola F, Saracco G, Ciccone G, Baldi I, Abate ML, Smedile A, Rizzetto M. Department of Gastro-Hepatology, San Giovanni Battista (Molinette) Hospital, Torino, Italy.
Several factors, including metabolic profile, are predictive of response to standard antiviral therapy in patients with chronic hepatitis C. In a retrospective study, it was investigated whether uric acid, involved in metabolic syndrome, could be included. A total of 153 patients (56.2% males; mean age 45.7 +/- 11.3 years) treated with pegylated-interferon and ribavirin were included. Eighty-five were infected with hepatitis C virus (HCV) genotype 1 or 4 and 68 with genotype 2 or 3. Viral load was >1,000,000 IU/ml in 101, < or =1,000,000 IU/ml in 35 and unknown in 17 patients. Ishak fibrosis score was 4 in 15 and unknown in 57 patients. Mean serum uric acid was 5.05 +/- 1.3 mg/dl. Sustained virological response (negative serum HCV-RNA 6 months after treatment cessation) was achieved in 102 patients (67%). In the final logistic model, serum uric acid level > or =5.8 mg/dl (OR = 0.46; 95% CI: 0.30-0.62), viral load (OR = 0.29; 95% CI: 0.09-0.92) and HCV genotype (OR = 0.23; 95% CI: 0.09-0.60) were identified as the most important factors independently influencing clinical outcome. The prognostic role of serum uric acid was confirmed on the sub-sample reporting Ishak fibrosis score (OR = 0.49; 95% CI: 0.28-0.85). SERUM URIC ACID
LEVEL > or =5.8 mg/dl IS PREDICTIVE OF POOR RESPONSE TO HCV TREATMENT. Prospective studies are needed to clarify the issue.
http://www.ncbi.nlm.nih.gov/pubmed/18297716?ordinalpos=118&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
----------------------
I told you that you needed to get checked for insulin resistance. High uric acid is associated with having insulin resistance and hyperinsulinemia.
"In the present study, URIC ACID had an independent, significant association with metabolic syndrome in different logistic analyses, SHOWING A CONSISTENT RELATION TO INSULIN RESISTANCE. Uric acid actually correlated significantly with the fasting and two-hour insulin levels (r = 0.34). These findings are in agreement with the previous studies, in which uric acid has been connected with insulin resistance as measured with the euglycemic clamp technique or the insulin suppression test (Modan et al. 1987, Facchini et al. 1991, Vuorinen-Markkola & Yki-Järvinen 1994). This relationship persisted when the differences in age, sex, overall obesity and abdominal obesity were taken into account. Facchini et al. found (1991) that URINARY URIC ACID CLEARANCE DECREASES IN PROPORTION TO INCREASES IN INSULIN RESISTANCE in normal volunteers, leading to an increase in the serum uric acid concentration. The mechanism explaining the observed association is unclear. On the one hand, there are mechanisms implying DECREASED RENAL EXCRETION OF URIC ACID IN THE PRESENCE OF HYPERINSULINEMIA, including increased levels of ketoacids and increased sodium reabsorption with the elevation of uric acid (Modan et al. 1987). On the other hand, there are mechanisms associated with increased production of uric acid. Uric acid is a purine base that may originate from turnover and degradation of various phosphate nucleosides, such as ATP, or dinucleotides. Increased ATP turnover has, in turn, been shown to explain hyperuricemia induced by ethanol, acetate and fructose." (Vuorinen-Markkola & Yki-Järvinen 1994).
---------
"Is the high uric acid level the cause of my back pain?? "
---------------------
Since there's decreased excretion of uric acid by the kidneys, that's probably what's causing the pain.
"How can i lower these levels?? "
---------------------
There is medication that can lower the uric acid. But you need to also take care of what's CAUSING the high uric acid. In other words, you need to do something about the insulin resistance.....because having high uric acid levels IS PREDICTIVE OF POOR RESPONSE TO Hep C treatment!!!
Co
(J Med Virol. 2008 Apr;)
"Is serum uric acid a predictive factor of response to IFN-treatment in patients with chronic hepatitis C infection?"
Pellicano R, Puglisi G, Ciancio A, Balzola F, Saracco G, Ciccone G, Baldi I, Abate ML, Smedile A, Rizzetto M. Department of Gastro-Hepatology, San Giovanni Battista (Molinette) Hospital, Torino, Italy.
Several factors, including metabolic profile, are predictive of response to standard antiviral therapy in patients with chronic hepatitis C. In a retrospective study, it was investigated whether uric acid, involved in metabolic syndrome, could be included. A total of 153 patients (56.2% males; mean age 45.7 +/- 11.3 years) treated with pegylated-interferon and ribavirin were included. Eighty-five were infected with hepatitis C virus (HCV) genotype 1 or 4 and 68 with genotype 2 or 3. Viral load was >1,000,000 IU/ml in 101, < or =1,000,000 IU/ml in 35 and unknown in 17 patients. Ishak fibrosis score was 4 in 15 and unknown in 57 patients. Mean serum uric acid was 5.05 +/- 1.3 mg/dl. Sustained virological response (negative serum HCV-RNA 6 months after treatment cessation) was achieved in 102 patients (67%). In the final logistic model, serum uric acid level > or =5.8 mg/dl (OR = 0.46; 95% CI: 0.30-0.62), viral load (OR = 0.29; 95% CI: 0.09-0.92) and HCV genotype (OR = 0.23; 95% CI: 0.09-0.60) were identified as the most important factors independently influencing clinical outcome. The prognostic role of serum uric acid was confirmed on the sub-sample reporting Ishak fibrosis score (OR = 0.49; 95% CI: 0.28-0.85). SERUM URIC ACID
LEVEL > or =5.8 mg/dl IS PREDICTIVE OF POOR RESPONSE TO HCV TREATMENT. Prospective studies are needed to clarify the issue.
http://www.ncbi.nlm.nih.gov/pubmed/18297716?ordinalpos=118&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
BB81
I have had at least 12 uric acid kidney stones and 2 operations for stones that were too large to pass so here is what I have learned.
There are many types of kidney stones. Most kidney stones are not uric acid stones.
If you have a kidney stone you need to make it pass. To do that the best thing to do is drink plenty of water. So much that you are not even thirsty and your sick of water. Keep a water bottle with you all the time a sip it from time to time. The other thing to do is to stay active. Walk around keep moving. That will get the stone to move.
Do you have a history in your family of kidney stones? It is common to have a history in the family.
When you say you have a problem with your back. What does it feel like? Does it come on in waves of pain? The pain can appear to come from different areas. Many people think they have back pain at first. The pain can also appear to be in the crotch area or the tip of your penis. Fun right? On a scale of 1 to 10 what is the level of pain? The classic answer is 15! The worst pain I have ever felt.
Remember many stones are difficult to find. Even with a KUB (Kidney, Ureter, Bladder x-ray) or ultra sound. The urologist will probably take a urine sample. Even though you can't see it, there may be blood in your urine, which is an indication of a stone. The stones tend to cut the ureters when trying to come out. Uric acid stones look like crystals with very sharp edges that cut into the ureter when it tightens around it to push it along.
In summary, if you do have a uric acid stone(s) you need to increase the amount of water you drink and stay away from red meats (purine) and salt. There are some othre foods too. As these cause the uric acid stones to form. Also your doctor can give you Flomax which will help you to pass large stones if needed. The med expands your ureters thus making them wider so a stone can more easily pass through. In December I had a 6mm stone that I passed using Flomax. It was painful for 3-4 weeks as the stone worked its way out but it beats a $30k operation and having tubes and other fun plumbing devices put inside you. Ouch!
Don't worry you can be on HCV treatment and have kidney stones. They are totally separate and do not interact in any way except they both can be painful in different ways.
I hope you find out that you don't have kidney stones, but if you do some of this info may be helpful.
Most of all good luck with your HCV treatment!!!
Cheers.
Hectorsf
I have had at least 12 uric acid kidney stones and 2 operations for stones that were too large to pass so here is what I have learned.
There are many types of kidney stones. Most kidney stones are not uric acid stones.
If you have a kidney stone you need to make it pass. To do that the best thing to do is drink plenty of water. So much that you are not even thirsty and your sick of water. Keep a water bottle with you all the time a sip it from time to time. The other thing to do is to stay active. Walk around keep moving. That will get the stone to move.
Do you have a history in your family of kidney stones? It is common to have a history in the family.
When you say you have a problem with your back. What does it feel like? Does it come on in waves of pain? The pain can appear to come from different areas. Many people think they have back pain at first. The pain can also appear to be in the crotch area or the tip of your penis. Fun right? On a scale of 1 to 10 what is the level of pain? The classic answer is 15! The worst pain I have ever felt.
Remember many stones are difficult to find. Even with a KUB (Kidney, Ureter, Bladder x-ray) or ultra sound. The urologist will probably take a urine sample. Even though you can't see it, there may be blood in your urine, which is an indication of a stone. The stones tend to cut the ureters when trying to come out. Uric acid stones look like crystals with very sharp edges that cut into the ureter when it tightens around it to push it along.
In summary, if you do have a uric acid stone(s) you need to increase the amount of water you drink and stay away from red meats (purine) and salt. There are some othre foods too. As these cause the uric acid stones to form. Also your doctor can give you Flomax which will help you to pass large stones if needed. The med expands your ureters thus making them wider so a stone can more easily pass through. In December I had a 6mm stone that I passed using Flomax. It was painful for 3-4 weeks as the stone worked its way out but it beats a $30k operation and having tubes and other fun plumbing devices put inside you. Ouch!
Don't worry you can be on HCV treatment and have kidney stones. They are totally separate and do not interact in any way except they both can be painful in different ways.
I hope you find out that you don't have kidney stones, but if you do some of this info may be helpful.
Most of all good luck with your HCV treatment!!!
Cheers.
Hectorsf
Just a reminder that any fruit JUICE has a high natural sugar content and can spike your glucose level.
I do drink alot of Grape Juice it has alot of vitamin C also.. I will try the cranberry juice.. I need to do something.. I will keep u posted..
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