SRV12 Survey Says! Sovaldi/Olysio (Sofosbuvir/Simeprevir)

[Talisman51]

Looking for SRV (sustained virological response) feedback for those of us finished with a 12 week protocol of  Sovaldi/Olysio.  My doc here in Chicago claims people are just now finishing their 12 week treatments.  Anybody like to share there SRV4 (four week post tx), SRV8 (8 weeks post tx), SRV12 experience please?  Please include specifics like geno, cirrhosis, q80k...  Thank you in advance.  

[Sovaldi13Newbie]

Oh, and I'm a 1b.

[Sovaldi13Newbie]

Just did my last viral load (today) while on treatment of Sovaldi Olysio and will end treatment (3 months) Wednesday. I have a complication in that I had a bone-marrow transplant from having had leukemia 2 years ago, and I'm still on a bit of immune suppression. But all through this treatment my labs have been wonderful, my liver function tests all great, just a bit of a drop of my platelets, nothing serious. I went in with 3 million viral load, 0-1 liver damage on biopsy. So at least my liver isn't that bad, but the symptoms of the virus itself were kicking my butt. (Mixed with everything else.) My symptoms were anxiety (especially an hour after taking meds and exhaustion, mild depression. I am so glad I'm getting off this stuff in a few days, but it was very doable, not like what I have heard about the old SOC. Oh, and I was treatment naive had this for over 30 years.

[Talisman51]

Bumping this up.   Now that more of us are EOT.   Thanks for sharing.

[Talisman51]

Mark, what was the rationale in adding the riba to the mix in your case?  Was it the past tx  pattern?  Believe you nailed it this trip,   Srv4 is huge!  Thanks Mark,  

[Talisman51]

Let's keep up the community for this valuable real life  survey.   Thank you to all contributors and best wishes to all for a new start in life.

[NYCMark]

Hey there!
Completed my 12 week treatment SIM/SOF + Riba on April 7.  My SVR4 was undetected.  Will report back on my SVR12 in July.  My treatment was complicated by rise in bilirubin, and anemia.  I had to lower by dosing of ribavirin from 1000 to 600 daily.  Bilirubin remained elevated until end of treatment.  ( I had been treated 4-5 times previously with some form of interferon/Peg + Ribavirin, with relapse each time.  I am GT 1a, q80K not tested, CC allele.

Good luck to all!!!
Mark

[Livelife777]

Great idea Tal as we all kinda started the same time, and interested to see how everyone is doing.   Think my starting date was early on the new meds.    Geno 2, cirrhotic, 12 weeks Sovaldi and Ribavirin.   EOT was April 7th.    My follow up post SVR4 was UND.   Will be cheering for all.      ..Kim

[candyce1953]

I am /was geno 1B :-)

Had hep c 43 years , no previous treatment, TT , stage 3 fibrosis, and I have an auto immune disease so could not take interferon, so I waited, till Sovaldi and olysio to treat, started feb 11th
Finished 12 week treatment, four weeks ago

I was a bit over 400,000 viral load starting, undetected 4/812 weeks

One week after finishing I was still undetected , now am waiting on results of my 4 week after treatment blood work done yesterday

Here is to SVR (fingers crossed) for you, for me and everyone !!
Xo
CH

[51panhead]

hey there Talisman. I finished my treatment with sovaldi & olysio. I am stage two and have had hep c for a little over 30 years. I have never done any treatment before this as my friends were having bad side effects and returns of the virus. 12,600,000 viral in the beginnig. When I stared this treatment my wife worked diet really hard. got down to a little over 500,000 over the years! at week one i showed normal liver function and virus free. kept up the treatment for the full 12 weeks and just took my blood after treatment. I have stage 4 liver and now am working to find ways to rejuvinate, so if anyone is looking into that any help would be appreciated. If your on treatment hang in there! I had vesy little side effects, fatigue