Aa
Lowering doses, labs
Hi All.
To brief: Pegasy/Riba doses just lowered from:
Peg: 180mg to 135mg.
Riba: 800mg to 600mg
In 'only' week 6
In a trial, no rescue drugs. Higer doses had me 100% bedridden (?)
After reviewing all labs, sides, type2b, etc. Dr. decided to lower.
Shands app. yesterday. I am UND, RVR at 4 weeks. Not 'allowed' to tell me but 'overheard' I was at 2 weeks (?) and getting the best response, etc. New plan in tx is........
Doing this dose a couple more weeks, watching labs. Than probably lower to 90mg Peg.
His goal....to keep some of these drugs in me, stave off anemia (getting taken off tx) for at least 10 more weeks, reaching 16.
I am very comfortable with Shands and my Dr. and he is quite secure in just getting me to 16 weeks and I will reach SVR. Said my labs 'holding up okay'. Of course if doing well, I will do more weeks.
I don't know the 'labs' too well yet. learning. Posting what I think is needed for an opinion.
Whatever is dropping......can it stabilize out, get better with just lowering dose's?
RBC. Start 4.46... wk4 3.50
Hgb: " " 13.9 wk4 11.3
HCT " " 42.3 " " 33.0
PLT " " 204 " " 197
WBC " " 6.1 " " 4.0
Neuts " " 4.2 " " 2.3
AST " " 46 " " 28
ALT " " 59 " " 19
Alb " " 4.3 " " 4.1
T Bili " " 0.4 " " 0.6
(What are neuts??)
VL load at start of tx was 1,550,000
I don't know these to well, but don't see anything that would make me 'drop to my knee's', as happened 2 weeks ago.??
Any opinions helpful, thanks.
LL
To brief: Pegasy/Riba doses just lowered from:
Peg: 180mg to 135mg.
Riba: 800mg to 600mg
In 'only' week 6
In a trial, no rescue drugs. Higer doses had me 100% bedridden (?)
After reviewing all labs, sides, type2b, etc. Dr. decided to lower.
Shands app. yesterday. I am UND, RVR at 4 weeks. Not 'allowed' to tell me but 'overheard' I was at 2 weeks (?) and getting the best response, etc. New plan in tx is........
Doing this dose a couple more weeks, watching labs. Than probably lower to 90mg Peg.
His goal....to keep some of these drugs in me, stave off anemia (getting taken off tx) for at least 10 more weeks, reaching 16.
I am very comfortable with Shands and my Dr. and he is quite secure in just getting me to 16 weeks and I will reach SVR. Said my labs 'holding up okay'. Of course if doing well, I will do more weeks.
I don't know the 'labs' too well yet. learning. Posting what I think is needed for an opinion.
Whatever is dropping......can it stabilize out, get better with just lowering dose's?
RBC. Start 4.46... wk4 3.50
Hgb: " " 13.9 wk4 11.3
HCT " " 42.3 " " 33.0
PLT " " 204 " " 197
WBC " " 6.1 " " 4.0
Neuts " " 4.2 " " 2.3
AST " " 46 " " 28
ALT " " 59 " " 19
Alb " " 4.3 " " 4.1
T Bili " " 0.4 " " 0.6
(What are neuts??)
VL load at start of tx was 1,550,000
I don't know these to well, but don't see anything that would make me 'drop to my knee's', as happened 2 weeks ago.??
Any opinions helpful, thanks.
LL
Merrybe.......Glad CS set that straight, I thought you had them backwards as acute is earlier, chronic when symptoms hit, etc.
WHAT are the white lumps on the brain??? I so understand the Dr.'s that just don't HEAR you. I saw so many and as I 'look' so healthy.....kept sending me home with 'Oh your depressed" and other cr*p! (NOT...have a good life!) and than finally started doing testing, but never caught high ALT's, AST's for YEARS! (have labs from 1998, high!). They even, in 2003, did check for Hep. but ONLY A & B !! Figure that one out! As for "oh, she's been on the internet", H*LL yes we were, trying to self diagnose ourselves! I was so d*m sick of aching, hurting, being soooo tired and starting to think " GOD, IS this really all in my head"?? Even finally getting dx with Hep ended up being a relief, to KNOW what is wrong! Just blows my mind that so many of us can carry 20-30 years and it's never caught?? H*ll, they have vaccines now, why is is not in 'normal' blood work checks??
What is with the spinal cord deal and what of the things you have going on, are from Hep?
I hope you are getting all these things dealt with, checked, followed up.
LL
WHAT are the white lumps on the brain??? I so understand the Dr.'s that just don't HEAR you. I saw so many and as I 'look' so healthy.....kept sending me home with 'Oh your depressed" and other cr*p! (NOT...have a good life!) and than finally started doing testing, but never caught high ALT's, AST's for YEARS! (have labs from 1998, high!). They even, in 2003, did check for Hep. but ONLY A & B !! Figure that one out! As for "oh, she's been on the internet", H*LL yes we were, trying to self diagnose ourselves! I was so d*m sick of aching, hurting, being soooo tired and starting to think " GOD, IS this really all in my head"?? Even finally getting dx with Hep ended up being a relief, to KNOW what is wrong! Just blows my mind that so many of us can carry 20-30 years and it's never caught?? H*ll, they have vaccines now, why is is not in 'normal' blood work checks??
What is with the spinal cord deal and what of the things you have going on, are from Hep?
I hope you are getting all these things dealt with, checked, followed up.
LL
Zazza......it would say more if the concentration of riba in the serum was measured, not just dose by weight. ------------------
So ask them if they do that? Do they ? would think they do.
Thanks for posting your labs. Think my 2.6 drop in hgb within 2 weeks is what put me to the floor? Week 1 thru week 2 yours dropped 3, did that hit you hard? Have you had to do any rescue drugs or has your hgb kept itself at those levels?
I also think (read here) the body has to adapt. Bless you in week 52 of 72! You sound very together for 52 weeks!!
LL
So ask them if they do that? Do they ? would think they do.
Thanks for posting your labs. Think my 2.6 drop in hgb within 2 weeks is what put me to the floor? Week 1 thru week 2 yours dropped 3, did that hit you hard? Have you had to do any rescue drugs or has your hgb kept itself at those levels?
I also think (read here) the body has to adapt. Bless you in week 52 of 72! You sound very together for 52 weeks!!
LL
Awake, but alert ??? :}
CS.....curious, what exact tx did you do? That just so sucks you didn't SVR :{, what a blow with type 2. I may have read it already (duh days)....but are you going to tx again? Another duh...but thanks, remembered the 'log drop' is VL drop.
The name....... cute, for awhile I thought it was a 'guy' thing :}
--------------------------
"Roche recommend dropping a pill when it gets below 10 and keep dropping one till it hits 8.5.
Then you stop. At 8.5 you wouldn’t be doing a lot of running - lol "
-------------------------
I could be wrong, I thought when it hit 10 or below they could drop me from trial. I will check that again. What is considered dangerous level? So stop tx if it hit's 8.5?
And I ain't even walking fast at 11.3 !
Thanks for clearing up the acute/chronic thing......thought it was my brain fog or she had it backwards.
LL
I weighed 76 kgs or so when I was on tx. So my Riba Dose was roughly the same as yours is on 600mg. Bad example though not only didnt I RVR, I didnt even EVR, and I wont talk about SVR.
For me I underdosed. Your situation is different being RVR.
The important thing for you is to complete the Tx, the quantity is less important. The drop in drugs should bring you back into the land of the living and then you and/or Doc can decide whether to increase the dose of one or other drug. What zazza says about the Riba dose holds true for us G2s and 3s but mainly when were do not RVR.
By 2 points I ment 2gram/dL. As for logs you dont have any to drop. You are log 0 ie UND.
The name comes from an 80s UK Punk band but I miss splelt it, shoulda been CockSparrer. Dont put a space in and it wont blank it out. It thinks you are swearing.
Merrybe
Acute means any disease that lasts for less than 6 months. Chronic is longer than 6 mths.
As this Acute phase is when symptoms occur ie with HepB it can also be more severe than when a disease becomes chronic. With HepC your ALTs can be up to 20xULN in the acute phase.
Its late so I hope that makes sence
CS
For me I underdosed. Your situation is different being RVR.
The important thing for you is to complete the Tx, the quantity is less important. The drop in drugs should bring you back into the land of the living and then you and/or Doc can decide whether to increase the dose of one or other drug. What zazza says about the Riba dose holds true for us G2s and 3s but mainly when were do not RVR.
By 2 points I ment 2gram/dL. As for logs you dont have any to drop. You are log 0 ie UND.
The name comes from an 80s UK Punk band but I miss splelt it, shoulda been CockSparrer. Dont put a space in and it wont blank it out. It thinks you are swearing.
Merrybe
Acute means any disease that lasts for less than 6 months. Chronic is longer than 6 mths.
As this Acute phase is when symptoms occur ie with HepB it can also be more severe than when a disease becomes chronic. With HepC your ALTs can be up to 20xULN in the acute phase.
Its late so I hope that makes sence
CS
OK, but it was only little punches and it felt good!!! more like pokes.....: ))))))
anyway, it broke the pain signal for a few seconds and every second counted...
LAuri,
don't know that I wasn't chronic for years, because I kept telling my GP something was wrong with my spleen and liver/gall bladder/ and brain and spine...and she kept saying it was all hooey. turns out I was right on all counts, Brain white lumps, pituitary shut down, spleen anlarged and liver inflammed with Hep C and spinal cord bent with several ruptures....all the things I told her were wrong for years...while she told me I was clueless, and refused to test for any of it.
so I count the chronic going to acute stage when it got so inflammed I ended up in emergency doubled up in pain....with fever chills and unable to get out of bed or stop shivering for weeks...
maybe that's not what acute means...I don't know for sure...it sure seemed acute to me. then to hear I was already at stage 3/4 when they FINally figured it out.....kinda confirmed that I should have never taken initial baby caca tests as accurate. or definitive, never let a year go by when she said, oh you wouldn't have that it's extrememly rare........I should have fought a lot harder....but I did fight harder than most..the sicker I got the more I fought.....or else I'd still not have found out about the brain or spleen or liver or back.
The docs are all reluctant to do any testing unless you can prove in spades it might be whats wrong.
they would just as soon send you home with pills and say you have chronic fatique or whatever as to run the simple blood tests to rule out infectious disease.
So I went into trials for more testing...and I went to another doc in the same supposedly great practice...and got told the same thing...well we never test for that, it's rare.....grrrrrrr.
in my charts they keep writing something they don't like about me....always making notes.about it...
"she's been reading on the internet" oooouuuu me bad....yeah and if I hadn't, I'd be dead already.
anyway, it broke the pain signal for a few seconds and every second counted...
LAuri,
don't know that I wasn't chronic for years, because I kept telling my GP something was wrong with my spleen and liver/gall bladder/ and brain and spine...and she kept saying it was all hooey. turns out I was right on all counts, Brain white lumps, pituitary shut down, spleen anlarged and liver inflammed with Hep C and spinal cord bent with several ruptures....all the things I told her were wrong for years...while she told me I was clueless, and refused to test for any of it.
so I count the chronic going to acute stage when it got so inflammed I ended up in emergency doubled up in pain....with fever chills and unable to get out of bed or stop shivering for weeks...
maybe that's not what acute means...I don't know for sure...it sure seemed acute to me. then to hear I was already at stage 3/4 when they FINally figured it out.....kinda confirmed that I should have never taken initial baby caca tests as accurate. or definitive, never let a year go by when she said, oh you wouldn't have that it's extrememly rare........I should have fought a lot harder....but I did fight harder than most..the sicker I got the more I fought.....or else I'd still not have found out about the brain or spleen or liver or back.
The docs are all reluctant to do any testing unless you can prove in spades it might be whats wrong.
they would just as soon send you home with pills and say you have chronic fatique or whatever as to run the simple blood tests to rule out infectious disease.
So I went into trials for more testing...and I went to another doc in the same supposedly great practice...and got told the same thing...well we never test for that, it's rare.....grrrrrrr.
in my charts they keep writing something they don't like about me....always making notes.about it...
"she's been reading on the internet" oooouuuu me bad....yeah and if I hadn't, I'd be dead already.
I hate answering on these can't sleep, late, brain fog nights!
Just saw your post of your hgb levels zazza, than saw my questions worded all wrong so going to re-read and post in the AM AFTER sleep, so I won't get annoying!
Please watch for it as my last post was a bit 'lost' and ...........thank you.
LL
Just saw your post of your hgb levels zazza, than saw my questions worded all wrong so going to re-read and post in the AM AFTER sleep, so I won't get annoying!
Please watch for it as my last post was a bit 'lost' and ...........thank you.
LL
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