Natalie Cole gets a kidney transplant

May 21, 2009 -- Singer Natalie Cole is "resting comfortably" at Cedars-Sinai Medical Center in Los Angeles after undergoing a kidney transplant operation on May 18, according to Cole's web site.

Cole may be able to leave the hospital as early as next week, her spokeswoman tells WebMD.

Cole went public with her hepatitis C in 2008. "Thankfully, her hepatitis C has been completely cured" by treatment given before the kidney transplant, Cole's spokeswoman tells WebMD via email.

Hepatitis C is a liver disease caused by infection with a virus. It damages the liver, which may lead to a need for liver transplant.

But Cole got a kidney transplant, not a liver transplant, and she recently said she believes her hepatitis C treatment was the source of her kidney problems, though she admitted her doctors aren't sure about that.

Natalie Cole's Hepatitis C
During an April 2009 interview on CNN's Larry King Live, Cole said that she was diagnosed with hepatitis C in February 2008 and that she believes she became infected with hepatitis C from illicit drug use years earlier, though she didn't know it. Cole is now sober.

On the show, Cole said she started taking a drug called interferon in May 2008 to fight the hepatitis C virus and that both of her kidneys were failing. She started kidney dialysis.

Cole attributes her kidney problems to her interferon treatment, but says her doctors haven't acknowledged that interferon caused her kidney problems.

"When I talk with my own doctor, he didn't say no and he didn't say yes," Cole said.

"You believe it, though?" King asked her.

"Absolutely, yes; with every bit of my body. I never had a kidney problem in my life," Cole said.

Hepatitis Expert Weighs In
"I think she's mistaken" about interferon causing her kidney problems, says Bruce R. Bacon, MD, director of the division of gastroenterology and hepatology at St. Louis University School of Medicine.

Bacon, who isn't treating Cole and doesn't have details of her case, tells WebMD he doesn’t know of interferon carrying any kidney risks.

"I've [treated] thousands of patients with interferon and not seen any kidney problems from that. I've used it in people with kidney disease, as well," Bacon says.

Bacon notes that a very small percentage of hepatitis C patients, probably less than 5%, develop kidney problems related to their hepatitis.

But he's not sure that's what happened to Cole.

"I don't know that her kidney disease is due to her hepatitis C," Bacon says. "It might be due to blood pressure or diabetes or something else. I just don't know what the cause of her kidney disease is.

"I suspect that what happened was while she was on interferon being treated for her hepatitis C, she had worsening of her kidney function, and it was what we call true-true-and-unrelated. True that she had treatment and true that she had kidney disease, but they were totally unrelated," Bacon says.

[pjhep80]

... my friend billy died of both liver and kidney failure... if they dont think the interfuron is causing kidney problems, is it the hepc that is effecting the kidney's?  alot of people with hepc also seem to have kidney issues