Gilead Electron trial results

[Cheesegrater]

Today, Gilead announced that 9/9 previous null responders to interferon/ribavirin achieved SVR4 (UND 4 weeks post treatment) when treated with GS-7977, GS-5885  and ribavirin for 12 weeks. This data is from one of the ELECTRON study arms.
I want to know how many of these 9 patients were GT 1a/1b.  Does anybody have a link to this information?

Cheese

[rivll]

http://www.fiercebiotech.com/story/year-after-11b-buyout-gilead-track-blockbuster-hep-c-program/2013-01-07?utm_source=rss&utm_medium=rss

This is all I could find so far...

[rivll]

http://www.fiercebiotech.com/story/year-after-11b-buyout-gilead-track-blockbuster-hep-c-program/2013-01-07

Better link

[printze]

www.gilead.com/pr_1771657 here is the press release I recieved yesterday from Gilead hope it works.

[HectorSF]

'I want to know how many of these 9 patients were GT 1a/1b.  Does anybody have a link to this information? '

90% were genotype 1a. So 1 or none were 1b.
1a's are harder to treat with with current 3 drug therapies because of more resistance variants.


AASLD 2012: Sofosbuvir + GS-5885 + Ribavirin Shows High Early Response Rates for Genotype 1 HCV

Published on Thursday, 15 November 2012 00:00 Written by Liz Highleyman

http://www.hivandhepatitis.com/hepatitis-c/hepatitis-c-topics/hcv-treatment/3860-aasld-2012-sofosbuvirgs-5885ribavirin-shows-high-early-response-rates-for-genotype-1-hcv

'Nearly 90% of participants had difficult-to-treat HCV subtype 1a -- typical of the hepatitis C population in Australia, Gane noted. None had liver cirrhosis. Among treatment-naive patients assigned to either regimen, about 40% had the IL28B CC gene variant associated with good response to interferon; as expected, only 20% of null responders in the dual-therapy arm and none in the triple-therapy arm had this favorable pattern.'

P.S. I am a prior null-responder and became undetectable by week 2 with only GS-7977 + Ribavirin. I didn't have the addition of GS-5885.

H

[Cheesegrater]

You say 90% were genotype 1a. Can you tell me where this is documented?

From article dated nov 2012...
...snip
"Among treatment-naive patients assigned to either regimen, about 40% had the IL28B CC gene variant associated with good response to interferon; as expected, only"...snip

Thanks, good news all around , but... the above article includes  treatment-naives and all the nulls had not gone 4 weeks post treatment when this was written.

The data in the article is not specific to the NULLS only arm.

Anyone?