Aa
A
A
Close
Avatar_universal
ursodeoxycholic acid and hep c
One thing that HR told me when I recently went to see him was that ursodeoxycholic acid is important for hep c patients to take.

http://www.hivandhepatitis.com/hep_c/news/2007/070607_a.html


"Combination therapy with pegylated interferon (Pegasys or PegIntron) plus ribavirin has improved treatment for chronic hepatitis C, but many patients -- especially those with genotype 1 HCV -- fail to achieve sustained virological response. Such individuals could benefit from therapies that reduce liver inflammation and fibrosis, even if they do not produce virological suppression.

As reported in the June 25, 2007 advance online edition of Gut, researchers from the University of Tokyo assessed the effect of oral ursodeoxycholic acid (UDCA) on serum biomarkers in non-responders to prior interferon-based therapy. Chronic hepatitis C patients with elevated alanine aminotransferase (ALT) levels were randomly assigned to receive UDCA at doses of 150 mg/day (n = 199), 600 mg/day (n = 200), or 900 mg/day (n = 197) for 24 weeks. Changes in ALT, aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) were measured.

Results

• ALT, AST, and GGT levels decreased at week 4, then remained constant for the remainder of the drug administration period.

• The median changes in the UDCA 150, 600, and 900 mg/day dose groups, respectively, were:

- ALT: -15.3%, -29.2%, and -36.2%;
- AST: -13.6%, -25.0%, and -29.8%%;
- GGT: -22.4%, -41.0%, and -50.0%.

• All 3 biomarkers decreased significantly less in the UDCA 150 mg/day arm compared with the 2 higher dose groups.

• While changes in ALT and AST did not differ between the 600 and 900 mg/day dose groups, GGT was significantly lower in the 900 mg/day group.

• In a subgroup analysis, ALT decreased significantly in the 900 mg/day group when baseline GGT exceeded 80 IU/L.

• Serum HCV RNA levels did not change in any group.

• Adverse side effects were reported by 19.1% of the patients, with no differences between the 3 dose groups.

Conclusion

In conclusion, the authors wrote, "A 600 mg/day UDCA dose was optimal to decrease ALT and AST levels in chronic hepatitis C patients. The 900 mg/day dose decreased GGT levels further, and may be preferable in patients with prevailing biliary injuries."
Cancel
2 Answers
Page 1 of 1
Avatar_universal
Here's the full study:

http://gut.bmj.com/content/56/12/1747.full.pdf
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Avatar_universal
"Adverse side effects were reported by 19.1% of the patients, with no differences between the 3 dose groups."

In the study they elucidate that diarhoea was the most common adverse reaction and there were no severe adverse reactions.

The study is pretty impressive.

But, after looking around, it also appears to be very expensive.
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Your Answer
Avatar_universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
ursodeoxycholic acid and hep c
Submit Answer
A
A
Recent Activity
Avatar_f_tn
Blank
livn_learnn commented on Salivary gland disord...
11 hrs ago
Avatar_f_tn
Blank
Delawarewallflower is ... Comment
16 hrs ago
Avatar_f_tn
Blank
susan400 Just diagnosed w/Graves..st... Comment
21 hrs ago
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
163305_tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
317787_tn?1428318779
Blank
Dee1956
DC
446474_tn?1446351282
Blank
HectorSF
San Francisco, CA
Avatar_m_tn
Blank
can-do-man
IN
1815939_tn?1377995399
Blank
pooh55811
683231_tn?1438659664
Blank
flyinlynn
Auburn, WA
Hepatitis C Community Resources
RSS Expert Activity
233488_tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488_tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543_tn?1443740527
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
163305_tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
317787_tn?1428318779
Blank
Dee1956
DC
446474_tn?1446351282
Blank
HectorSF
San Francisco, CA
Avatar_m_tn
Blank
can-do-man
IN
1815939_tn?1377995399
Blank
pooh55811
683231_tn?1438659664
Blank
flyinlynn
Auburn, WA