Aa
A
A
Close
Avatar universal
ursodeoxycholic acid and hep c
One thing that HR told me when I recently went to see him was that ursodeoxycholic acid is important for hep c patients to take.

http://www.hivandhepatitis.com/hep_c/news/2007/070607_a.html


"Combination therapy with pegylated interferon (Pegasys or PegIntron) plus ribavirin has improved treatment for chronic hepatitis C, but many patients -- especially those with genotype 1 HCV -- fail to achieve sustained virological response. Such individuals could benefit from therapies that reduce liver inflammation and fibrosis, even if they do not produce virological suppression.

As reported in the June 25, 2007 advance online edition of Gut, researchers from the University of Tokyo assessed the effect of oral ursodeoxycholic acid (UDCA) on serum biomarkers in non-responders to prior interferon-based therapy. Chronic hepatitis C patients with elevated alanine aminotransferase (ALT) levels were randomly assigned to receive UDCA at doses of 150 mg/day (n = 199), 600 mg/day (n = 200), or 900 mg/day (n = 197) for 24 weeks. Changes in ALT, aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) were measured.

Results

• ALT, AST, and GGT levels decreased at week 4, then remained constant for the remainder of the drug administration period.

• The median changes in the UDCA 150, 600, and 900 mg/day dose groups, respectively, were:

- ALT: -15.3%, -29.2%, and -36.2%;
- AST: -13.6%, -25.0%, and -29.8%%;
- GGT: -22.4%, -41.0%, and -50.0%.

• All 3 biomarkers decreased significantly less in the UDCA 150 mg/day arm compared with the 2 higher dose groups.

• While changes in ALT and AST did not differ between the 600 and 900 mg/day dose groups, GGT was significantly lower in the 900 mg/day group.

• In a subgroup analysis, ALT decreased significantly in the 900 mg/day group when baseline GGT exceeded 80 IU/L.

• Serum HCV RNA levels did not change in any group.

• Adverse side effects were reported by 19.1% of the patients, with no differences between the 3 dose groups.

Conclusion

In conclusion, the authors wrote, "A 600 mg/day UDCA dose was optimal to decrease ALT and AST levels in chronic hepatitis C patients. The 900 mg/day dose decreased GGT levels further, and may be preferable in patients with prevailing biliary injuries."
Cancel
2 Answers
Page 1 of 1
Avatar universal
Here's the full study:

http://gut.bmj.com/content/56/12/1747.full.pdf
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Comment
Post Comment
Avatar universal
"Adverse side effects were reported by 19.1% of the patients, with no differences between the 3 dose groups."

In the study they elucidate that diarhoea was the most common adverse reaction and there were no severe adverse reactions.

The study is pretty impressive.

But, after looking around, it also appears to be very expensive.
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Comment
Post Comment
Your Answer
Avatar universal
Answer
Do you know how to answer? Tap here to leave your answer...
Answer
Answer
Post Answer
A
A
Answer a few simple questions about your Hep C treatment journey.

Those who qualify may receive up to $100 for their time.
Explore More In Our Hep C Learning Center
image description
What Is Hepatitis C?
Learn about this treatable virus.
image description
Diagnosing Hepatitis C
Getting tested for this viral infection.
image description
Just Diagnosed? Here’s What’s Next
3 key steps to getting on treatment.
image description
Understanding Hepatitis C Treatment
4 steps to getting on therapy.
image description
Your Guide to Hep C Treatments
What you need to know about Hep C drugs.
image description
Managing Side Effects of Treatment
How the drugs might affect you.
image description
Making Hep C Treatment a Success
These tips may up your chances of a cure.
Recent Activity
317787 tn?1473362051
Blank
Dee1956 commented on Belle313's status
Sep 22
317787 tn?1473362051
Blank
Dee1956 commented on KeeLolo's status
Sep 22
Avatar universal
Blank
ali110786 commented on Why clinics sometimes...
Sep 22
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
Avatar universal
Blank
317787 tn?1473362051
Blank
DC
1747881 tn?1358189534
Blank
Greeley, CO
683231 tn?1467326617
Blank
Auburn, WA
7469840 tn?1409849436
Blank
San Diego, CA
Avatar universal
Blank
Hepatitis C Community Resources