IgE at 723 (normal is 30-40) any correlation to MS or? VB12 deficiency=MS?

[Miss_dx]

My IgE has been running high since the first time I know that it was checked in mid 2006-it was 700s. I was wondering if anyone knows if it has any bearing on MS? I ask bc my Dr who 1st thought I had MS checked it back then-is this a test for MS? I know that IgE has to do with immunology so I was wondering as it is still high mid 600s.
Also, I am VB12 deficient a taking shots for it. Anyone know of any correlation to VB12 deficiency & MS?
I had high Protien in my Spinal Tap. Isn't high Protien in a Spinal Tap Indicative of MS?
1st MRI report "No lesions" but, the Neuro looked at the MRI & said "There IS 1 lesion.
2nd MRI report said "Lesions are Insignificant". I looked at it & saw lots of UBOs & changes as well as questionable spots.
After I was told "All your tests came back negative for MS" by my previous Neuro I quit going to him but still reeling with symptoms, so I got a new Neuro!
3rd MRI report(same radilology as 2nd) says "Stable Brain as compared to 2nd MRI'. 'No lesions". It clearly shows MANY changes that you dont have to be a radiologist or a rocket scientist to see with even poor eyesight! Also there are 2 more white spots in the most common places for MS lesions! AND several more UBOs as well! It seems they forgot they ever mentioned the "insignificant lesions" before as now they claim there are no lesions?
Any ideas for me?
PLEASE, I need help & fast!

[COBOB]

I hope no one thinks I'm a radiologist .  In a prior career, I spent about 17 years in Biomedical Engineering.  So I understand how MRI works and many of the different sequences,  I spent many hours sitting at a GE Radworks console with Neuroradiologist and Interventional Radiologists at some of the DoD's largest teaching hospitals, so I may have picked up a bit along the way.

High IgE indicates an active immune response.  High IgE values are pretty common in allergic reactions.

Not all UBOs and bright spots are lesions.  You have to look at the sequence type and know how to "window and level" the image to bring the lesions out and suppress the unwanted data in the MRI.  In order for a T1 post contrast lesion to be a "real demyelinating lesion," the lesion must also show up on a T2W/T2* sequence.  MRI contrast used in brain imaging (Gd-DPTA) doesn't make demyelinating lesions show up, it just helps figure out if they are recent and if the blood brain barrier is "leaking."  Also, there are other UBOs that are not demyelinating lesions.

T2 demyelinating lesions look more like "eraser smudges" then  bright spots.  They are sometimes very hard to detect.  Radiologists use a methodical approach to scan the MRI images and they typically bring up several slices from different series in windows so they can compare the different sequences.  

Bob

[grannyhotwheels]

We do have a guy here that is a radiologist... I know once he sees this he will respond to you... I just feel so badly and I do sympathize with you as I know many here do... There are a lot of us that have been through several Neurologist over the years... So if your just on #2 your not doing that bad...

I know that's not what you want to hear but trust me... I personally have been to 5 or 6 maybe even more... I've seen so many doctors that I lost count and had it not been for my family I wouldn't have went back... They are the ones that made the appointments and drug me to the next appointment.

I'm so thankful for them now but at the time I was getting very depressed because every doctor had a different diagnosis for me and none of them where good... I had 2 tell me that I was dying and that I needed to get my affairs in order... So believe me when I say I understand what your going through...

I do hope you have family that can help you during this time... You should absolutely find another doctor, one who cares... I would look for a MS Specialist/Neurologist... Maybe you could go on line and look for a MS Center/Neurologist in your area or call your MS Chapter if there is one close to you to find out where the nearest one is...

I hope that our expert radiologist will look at your post and be able to help you out there... Please keep posting and let us help you through this bad time you are going through...

I'll be praying,
Carol

[Miss_dx]

Thank you for your input & your very valued opinion. You must have looked at my MRI as you mentioned what is so evident. Thank you for caring-looking & responding!
I intend to ask my Neuro to look at more than just the 3 xray films of my brain MRI WITH me! When he showed me those 3 xray films I had no idea there were abt 12 more! Not sure why he chose 'those 3', the ones with only one..clear spot which I asked him what that was & some iffy spots too? He mumbled as he turned away. It has been on all 3 MRIs getting less brite tho! I believe he showed me those 3 from the recomendation of the radiologist-I suspect! But, I did ask him "Did YOU look at my MRIs"? That was bc there were such differences between the 1st & 2nd ones (I hadnt yet seen the 3rd MRI). He told me "No, because I'm not a radiologist!" I've since spoken with an MS patient since who told me "If your Neuro won't look at your MRIs then find another who will"! I am too sick to keep trying to go find help! If I could just find an online radiologist who could simply read my MRIs and give honest answers to all the spots-changes etc in my MRIs? I'm abt to find an atty to get a radiologist to do an unbiased reading-then we'll see!
On 7-26-11 my Neurologist said "I'm giving you a prescription of Cymbalta for the nuropathy for MS". So, I am diagnosed- But what about the Beta ferons or meds to keep me from bouts or any other meds-treatments or something to help me? And, my next app with him is in 3 months! He scheduled another Spinal Tap tho but then they called bc he had an emergency-I decline to reschedule bc I don't know if I should let him do a spinal on me or just find another Neuro 1st? I've had 2 SPs! 1st one was never checked for anything MS(done w live xray at least)! 2nd (sitting on a gourney in the most filthy room in a hospital-with a cockroach motel on the floor behind the door! He (Neuro) hit a nerve that went down my right leg to just above the ankle & it burned so bad I almost fainted) it was high in Protien-but, I was told it was negative & didnt see my lab report for abt 1 1/2 year later! My Neurologist strait up lied to me! Now, I got a new Neurologist but wonder if he is afraid to go against the other one? The pic I posted is but 1 of many that I have questions about! I saw an MRI from some edu.gov site of 'Tuberous Lesions' that mine look so much like but mine has way more! My Brain is clearly not normal as I also saw at that site! It even looks as if it has missing portions & like it has a crack going thru it abt 1/3 of the way on one side of it as it shows up in several layers of the MRI pics! I'm just wondering if I can get them online to a REAL Radiologist & Neurologist?
I have been very symptomatic with less time in between. Now I have been having so much worse heart palpitations too than ever before! The burning has been worse too as well as my eyesight off/on. My gastro is a mess, spasms, profuse sweating, pain w/o cause. I've had electrical zips that seem as if I should've seen a spark! Everything is getting worse! I sit in bed & think of things I want to do & have energy but whenever I do something rarely can I finish anything! I think I can but then I cant. I may get to a store then be stuck w/o enuf energy to get to the car even. I have no energy to look for help!
I know I am venting too & almost ready to cancel this message to you but, I need help & there is so much to tell-someone! If only I could get those 3 MRIs read properly..If only I could find a good Neuro who had confidence enuf to say for sure...I've had so many symptoms that were documented way before I heard of MS that are indicative of MS. I just need to figure out how to get out of this 'Box' of medical 'Professionals' I got stuck in.
Thanks again for looking at my MRI, it helps to know that someone else sees what I see too & that my questions are valid ones. I have made up my mind to use every ounce of energy to get those answers to resolve this once & for all!
In fact, I'm gonna load those other MRIs too! I hope you will check back & see for yourself abt what appears crack in my Brain & those that appear to be Tuberous lesions.
Thank you so much, Miss_dx

[SarahL2491]

there were studies done for EB that linked to MS a number of years ago, two studies I think, is this anything close to your labs?

[Deb61]

I would ask that your neurologist goes over the MRI with you.  From my own experience, the radiologist does miss lesions.  I think you do indeed have lesions missed by the radiologist on the T1 with contrast.  What lousy luck you've had with radiologists!  If your neurologist doesn't have time to go over them with you, ask him/her when they do.  You deserve answers.

BTW, a T1 lesion (and you have at least two maybe more) with contrast means you have new and active lesions if you have MS.  Are you experiencing new symptoms lately?  If you are experiencing new ones, you need to let the neuro know.  They can at least note this in your records.  It's important information in the diagnostic phase.

Deb