My mom, 60 years old, living in Eastern Europe, has been experiencing progressive (but very slow) numbness and eventually loss of control of her right leg and most recently her right arm has just begun to feel slightly numb. As of now, she is not able to walk with one leg, she drags it and she can not bend it at the ankle. This condition has been going on for about 7-8 years. She was initially diagnosed with vasculitis, was prescribed prednisone, but gave it up right away because of serious side effect (arythmia, swelling). Then a different group of doctors suggested Progressive MS. The neurological tests showed the following (quoting doctors, pardon the translation):
Speech , meaning normal. Vision and hearing in normal limits. Ophthalmoscopic examination is in normal limits. Internuclear little ophthalmoplegia at horizontal look at both eyes; left is more evident. Evident ataxia. Romberg (+). Spastic quadriparesia; right is more evident. Tendon reflexes abnormally brisk. Distal hipoesthesia and position sense abnormality at lower libs. Cerebellar tests dismetric for all limbs; right is evident. Both sides babinski (+)
The treatment they suggest is:
1- Prednizolon 1000 mg/day. İ.V. infusion ( 5 days). (This period can up to 10 days due to clinical responses.
2- İmmuran 50 mg/day. (After one month 100mg/day, after two months 150mg/day continuation.)
3- Following up tests ( hemogram, CPK, SGOT, SGPT) must apply every 3 months.
4- Dodeks ampoule (1000 mg Vit B12)(1 ampoule/day i.m for one week period then 1 ampoule i.m, 2 weeks intervals )
5- Folbiol tab. 1x1 (250 mg folic acid/day oral).
She is very scared to try any type of Prednisone or Prednisolone after the side effect experience. Please, help if you have any specific ideas or recommendations.
Much appreciated.