possible MS

[shadais]

I have been experiencing several different symptoms especially sudden lose of balance which causes me to fall. I was diagnosed in 1995 at the age of 35 with fibromalagia and chronic fatigue syndrome at this time I thougth it might be MS. I was diagnosed by a primary care physician not a Neurologist. I have had 3 MRI, one in 2002 that showed increased periventricular  
T2 bright signal white matter bilaterally along the frontal horns more prominent on the left than right. The MRI

[danif]

I have been have headaches daily.  In 2003 I had an MRI that stated two punctate areas of focal demyelination in the dorona radiata on the right and two on the left.  My physician cannot exactly tell me what this is.  I am schedule for another MRI tomorrow and would like some answers.  My headaches are daily, I don't really have any other symptoms except light headedness.  Could you give me some information on this.

Thank YOu

[CCF-Neuro-M.D.-SH]

First of all, keep in mind that I am unable to diagnose you because I am unable to examine you, this forum is for educational purposes.
   Yes, you have a vaild concern about MS(multiple sclerosis).  The symptoms and story you describe can be found in MS, but you will need some more testing.  Multiple sclerosis is caused by an auto-immune reaction (your bodies immune system attacks your nervous system) and leads to focal loss of the Myelin ( a substance that surrounds nerves and allows them to function optimally). This appears clinically as a focal dysfunction (for example: optic nerve involvement->blurry/loss of vision, posterior fossa-> dizziness/vertigo, primary sensory cortex (parietal lobe of brain)->burning/tingling in arm or leg on one side). Along with the focal dysfunction is also fatigue, which can be severe. The reason people develop this auto-immune reaction is unknown.
   There are many things that can mimic MS, and thus we test for signs of focal demyelination and inflammation in the spinal fluid.  In fibromyalgia (there is no test for this) people complain of multiple sites of myofacial pain (pain under the skin) and this is thought to be related to sleep disorder (this would not explain your dizziness and vision problems).  The MRI findings of increased periventricular white matter changes in T2, is consistent with areas of focal demyelination in MS, but can also be from hypertensive disease(high blood pressure) and/or migraine headaches (your neurologist should be able to tell).
   I would recommend that you get a lumbar puncture (spinal tap) to evaluate your spinal fluid for signs of inflammation (cell count, tourtelotte panel (IgG index) and oligoclonal bands).  You should also have visual evoked potential (VEP) (tests for past optic neuritis) and a full ophthamological exam.  You should also have an MRI of your cervical spine with contrast as well (MS often affects the c-spine).  If your previous MRIs were not done with contrast, then you should have a repeat brain MRI with contrast and saggital FLAIR (a sequence on the MRI that help differentiate if periventricular lesions are due to MS)
  I cannot say if you have MS, but your story is consistent with possible MS, and I encourage you to get the testing done, so that disease modifying therapy can be started if the diagnosis is confirmed.
I hope this has been helpful.

[shadais]

I am sorry to hear about your husband, It;s a very frusrating
situation. Did your husband have an MRI and if so what was his result. I will certainly keep you posted. I wish you Both the best. Thank you for comment

[shadais]

I had relized that I was not specific enough. I also have had bout's with facial numbness, had CT scan (normal). I have also
had increased weakness in my hand's more on the left than right.
this was measured during a nueropsychological exam,also bilateral sensory/motor impairment more right than left, also cognitive and concentration skills were found to be very impaired it was suggested that a neurological reason my be the cause for these symptoms. So much information please help it make sense to me!!!!!!!

[rpeiffer2000]

This sounds alot like what my husband has going on would you please update me when you find something out?  We have been going through this for 13 years now and still no diagnosis.