Do you know if you have Hashimoto's Thyroiditis?
Hi Carl... Are you saying that your doctor jumped you from 25 mcg to 125 mcg, all at once? If so, that's quite a jump and not one that's usually done in one swoop.
The answer is "yes", you will, most likely feel it, however, it will take some time, as it takes 4-6 weeks for a dosage of levo to reach full potential in your blood.
I'm having a hard time justifying an increase of this nature...Did your doctor explain "why" s/he was prescribing such an increase? Do you have a copy of your most recent lab work you can post here, so we can see what's going on? Be sure to post the lab's reference ranges, along with any results, since ranges vary lab to lab and have to come from your own report.
Is low energy level the only symptom you have?