Their are many types of Opioid receptors and also subtypes of them,there are also ~sites? that one opioid ie(methadone)will bind(influence) that another Opioid ie(Hydrocodone)will not.
One thing that all Opioids have in Common is a resonable binding affinity for "Mu" Opioid receptors(PAIN) and stimulation of the Mesolimbic Dopaminergic VTA-Nucleus Accumbens reward circuit(EUPHORIA-unfortunate).
Methadone is goofing you out because it *(binds more tightly in relative global "Mu" receptor affinity to a sub-type) in the Mesencephalon area(brain stem) concerned with states of arousal and perception.
So it will make you spacey and drowsy and the Hydrocodone will make you "more" euphoric and alert and actived.
Methadone binds pretty strongly to gastrointestinal Opioid *receptors and is considered superior to morphine for stomach pain.
In fact I ONCE used so much Codeine SO often that instead of an Adrenalin RUSH resulting from fright I would get a Codeine RUSH,I have not bothered looking into the Neurophysiology behind this effect,but am not to surprised as Codeine is stimulant and will cause convulsions as per any stimulant in doses that are large(>300mg single oral dose).
Some Opioids are not very specific at all(Mu)receptor and are more Hallucinogenic than Analgesic,so they are not used much.
Also,It sounds like you are a Methadone Virgin,in which case you will have exquisite sensitivity,enjoy,while it lasts.
Methadone is ofen used for chronic pain sufferers in Australia,as it is considered qualitatively superior to Morphine for Chronic pain and can be given in a way that gives very stable blood levels,below is very approximate for single oral dose,nb Methadone will accumulate due to long half life.
10mg Methadone is equal to 30mg Morphine
30mg Morphine " " " 50mg Hydrocodone
Sir, I can only point out the difference in the two medications. Vicodin is a short acting medicine with actions similar to codeine. Methadone is a long acting medicine with actions similar to morphine. That is the basic difference. Methadone maintenance is about finding an adequate dose that stops all opiate cravings
and withdrawals. MMT is not about producing a high. Higher doses are needed some times to achieve this need. Pill addicts require doses in the 60-80 mg range to stop all cravings
and withdrawals. MMT is about being comfortable for 24 hours without cravings and withdrawals. Higher doses are needed to accomplish this feat. The high associated with methadone will rapidly disapate to produce a patient that functions without craving and withdrawals.
Dan...
What you say is correct,what do you think about bizziebe`s original question?.
From reading your post here and the one below, I would say that you need to be treated for panic and anxiety. My own wife has similar problems with narcotics and usually refuses them in favor of Xanax. She has cancer related pain and has been prescribed mega-doses of Lortab and Vicodin ES. She rarely uses them out of fear of addiction and the "funny feelings" they give her. For the life of me, I don't understand it! I'm just the opposite preferring opiates over benzos for pain. J.B.
I'm already getting treated for my panic attacks and anxiety with the medication Xanax, but scared to take it with the vicodin and the same reason I won't take Vicoidin every 4-6 hours as prescribed I don't want to get addicted to none of it and be all messed up, I know a few family member's that are addicted and only take them for the 'high' and that has always scared me. I make sure there is a lot of hours in between the two[VicodinEs, Xanax] if I need to take the Xanax. The whole reason I take the Vicodin is because I don't want to deal with my toothaches because they get so bad,and as I have said I don't have money to go to the dentist at this time, but will soon thank god, then I can stop panicing over all this! Haha.. But I wish I could only use the Xanax but they don't stop my pain..And I think I have done pretty good I've been on them for 4 years now but only take it when I have a panic attack which is maybe 2-3 times a week and sometimes 0 that week, I have learned to control my fear in some ways but sometimes the brain just takes over and I end up taking one if the attack stays with me for hours.. Thanks for your comment and good luck to your wife and you. ps:What is Opiates and Benzos??