Codeine(3-methylmorphine)
Dihydocodeine(7,8-Dihydro,3-Methylmorphine)-DF118
18mg of DF118 is Equivalent in Analgesic Potentcy to 30mg Codeine.
Heres the REAL difference,saturation of the 7,8 double bond (Alkene)increases blood brain permiability(more lipid soluble),resulting in more rapid affect and greater potency(less enterohepatic recycling and thus metabolic degradation),however it also changes receptor binding affinity and localization in SOME regional areas,resulting in a Qualitative improvement as well,thus with DF118; SWEETER euphoria and more SEDATION.A lot of these qualitative changes are linked to receptor regional localization specificities in Limbic entities like the Mamilary body,and Olfactory turbercle,thus the "TASTE" is better.Do not expect to find this information in any old Medical Text,this is cutting edge research,most not published yet.
I suppose that I could look this information up but what is the difference between plain codiene and dihydrocodiene? My brother-in law gets 8mg codiene and aspirin compound from Canada and gave me a rather large amount of this about two years ago. I wasn't really impressed with the stuff and we ended up taking it like any OTC pain reliever. We just kept the bottle on the kitchen table along with all the other normal OTC meds. I've had pure codiene before and found it to be pretty awful stuff. Maybe I'm allergic to it? J.B.
P.S.
I forgot to say that they are in Schedule II
The Dihydrocodeine Tartrate is known as DF118 in the UK, They come in 30 mg strength. Also they do not contain any other active ingrediance.
Ok,OK the "ceiling" dose varies amongst all individuals,I get side effects and no increased analgesia around 180mg(single oral dose) and you can handle 240mg(divided doses).It is not absolute.
What is known for sure is that it is the demethylation of Dihydrocodeine to Dihydromorphine that mainly contributes to its analgesic effects.The Enzyme(cyp2d6) required to do this will become progressively depleted from your liver and as a consequence a tolerance will occur rapidly.Morphine does not require "this" `specific` enzyme and although its bioavailability is around 23%(oral)it enzymatic metabolizing systems,do not contribute to Tolerace greatly,in fact continued Oral use can increase bioavailability.(first pass systemic bioavailability)
Dihydrocodeine is available OTC in Australia,in a compound tablet 7.5mg/300mg Aspirin,easily removed by dissoving in water and filtering.
Could you tell me if what you are taking is known as DF118 and the strength of tablets and what schedule they are in?.
Thankyou in advance.
I have never come across not exceeding 180 mg per day. (There is no paracetamol/tylenol in it, just Dihydrocodeine) Why should you not exceed this dose? The doctors seem to prefer me on the Dihydrocodeine to the Morphine and to be honest the morphine is a far better drug for killing the pain. Maybe thinking about it morphine does not have a ceiling to its effects, Dihydrocodeine above 240 mg a day has a ceiling to analgesic effect or so I have read.