I currently take Amiodarone 200mg a day, Metoprolol 100mg a day, Prilosec OTC 40mg a day. I have occasional Atrial Fibrillation. I was put on the Metoprolol in 2004 (my dosage is much lower now) and the Amiodarone in July 2008. I suffer greatly from panic attacks and extreme anxiety. My doctor prescribed Zoloft for me at 25mg a day for two weeks, then 50mg a day thereafter. He knows all the meds I currently take, of course. I've been reading online that Zoloft and Metoprolol can interact together in a dangerous way. I am sure my doctor knew this, so I am wondering why I was given this combination? Does anybody know about this interaction? Is it only dangerous if I were taking much higher dosages? I have to wait a month between each doctor appointment due to my terrible insurance, so I can't get an answer quickly. Any informed information would be great appreciated, as this anxiety has caused me to become home bound and to lose my job. Thank you.