Yes, you could probably do that if the pill can split that way and make even quarters. They'd be pretty small. Splitting a pill is easier. But you can try it. Zoloft is pretty tolerable it appears. And for many people it takes a higher dosage to be effective. I'd be surprised if 5o mg is where you end up as 100 mg is a more common dose. But time will tell with that. I'm so glad you are being treated. Did you see the psychiatrist? Have you started taking it yet? How are you feeling? Let me know how things go!