Aa
DR Mathur
Dr...I have had r/a for 30 yrs...had a cat scan yesterday for the liver and found out I have Honey comb w/sparing of the costphrenic angles likely fibrotic due to non specific interstitial penuonitis . history of sjogrens direct chest image requested Can you tell me anything about this? All I know is I clear my throat alot. Is it very severe? Can I live with this?
Hi PaulaAnn.
TNF-a causes also connective tissue breakdown. And guess what?
Boswellia Serrata can inhibit this destructive process.
Ref: PubMed.
Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA.
"Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia."
Note: The full effect may take a few weeks of supplementation.
Ensure highest quality of standardised Boswellia serrata extract, containing about 40% of Boswellia acids. There seem to be no established guidelines for dosage, but about 500mg x2 daily with food, is consistent with most practitioners' recommendations.
Please look into this as I feel, is worthwhile and with no known side effects-this has been used in Ayurvedic Medicine for 1000s of years, with no issues, as an anti-inflammatory.
AOR has a nanoAVAILABLE Boswellia supplement, if you wish to check it out . If you need the link let me know.
I think it has greater bio-avalibility in this form and very affordable compared to biologics outrageously high cost and possible side effects(specially reduced immune function).
Taking Boswellia with meals that contain fats (best is coconut oil-heated OK-, or olive oil but NOT heated!)the effectiveness gets boosted up to 700% (not a typo) when taken with fats!
Note:This is not intended as a substitute for medical advice.
Best wishes!
Niko
TNF-a causes also connective tissue breakdown. And guess what?
Boswellia Serrata can inhibit this destructive process.
Ref: PubMed.
Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA.
"Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia."
Note: The full effect may take a few weeks of supplementation.
Ensure highest quality of standardised Boswellia serrata extract, containing about 40% of Boswellia acids. There seem to be no established guidelines for dosage, but about 500mg x2 daily with food, is consistent with most practitioners' recommendations.
Please look into this as I feel, is worthwhile and with no known side effects-this has been used in Ayurvedic Medicine for 1000s of years, with no issues, as an anti-inflammatory.
AOR has a nanoAVAILABLE Boswellia supplement, if you wish to check it out . If you need the link let me know.
I think it has greater bio-avalibility in this form and very affordable compared to biologics outrageously high cost and possible side effects(specially reduced immune function).
Taking Boswellia with meals that contain fats (best is coconut oil-heated OK-, or olive oil but NOT heated!)the effectiveness gets boosted up to 700% (not a typo) when taken with fats!
Note:This is not intended as a substitute for medical advice.
Best wishes!
Niko
thanks looked up cvd.
feel like so much has piled up on me this past month.
i'm already on 5 mgs prednisone
feel like so much has piled up on me this past month.
i'm already on 5 mgs prednisone
thank you. i am on a biologic for my rheum arth called orencia. wonder if that has caused me issues. enbrel i took also.
i have mixed connective tissue disease.
i'll have to look up some of thge words you used...lol cvd...
i'm always open to oher approaches....most of the time..money is the issue.
i have mixed connective tissue disease.
i'll have to look up some of thge words you used...lol cvd...
i'm always open to oher approaches....most of the time..money is the issue.
The fibrosis in your suspected ILD( as Dr. Mathur mentioned) is characterized by chronic inflammatory cells with collagen deposition.
Have your doctor look into TNF-a (stimulating collagen deposition) and Interleukin-6( inhibiting collagen degradation) as possible causative agents
in this process. Ref. PMID: 7770462
This suspicion is consistent with CVDs profiles.
In the meanwhile, should you be interested to look at holistic approaches to inflammatory processes, let me know.
Wish you well!
Niko
Have your doctor look into TNF-a (stimulating collagen deposition) and Interleukin-6( inhibiting collagen degradation) as possible causative agents
in this process. Ref. PMID: 7770462
This suspicion is consistent with CVDs profiles.
In the meanwhile, should you be interested to look at holistic approaches to inflammatory processes, let me know.
Wish you well!
Niko
thank you. i never felt i had issues with my lungs. i was shocked. i cant see the dr till end of may. i only take 5 mg prednisone now. and orencia
MEDICAL PROFESSIONAL
Hi!
Honeycomb pattern of lung sets in if there is fibrosis. This is usually seen in interstitial lung diseases (ILDs), also called as diffuse parenchymal lung disease. Of all the ILDs, the honey comb pattern is most common in idiopathic interstitial pneumonias or in idiopathic nonspecific interstitial pneumonia (NSIP). As the name suggests, the pneumonia like condition of the lung has no known cause.
Honeycomb changes are also seen in autoimmune diseases such as sarcoidosis, lupus, rheumatoid arthritis, Sjogren’s syndrome, scleroderma etc. This group of diseases also also called as Collagen vascular diseases (CVDs). Of these, you have RA and Sjogren’s. If you have taken methotrexate for RA, then this drug too can precipitate ILD.
This is a serious condition. Prognosis will depend on the severity of the honeycomb pattern. There is nothing much which can be done, except keeping the RA and Sjogren’s flares under control. Also corticosteroids may be prescribed to reduce inflammation. You may also need oxygen therapy.
If you clear your throat a lot, then you could also be having a bad gastric reflux. This can also contribute towards development of interstitial pneumonitis. Treating the reflux can really slow down further damage. Do discuss this with your doctor and get yourself examined. Take care!
Honeycomb pattern of lung sets in if there is fibrosis. This is usually seen in interstitial lung diseases (ILDs), also called as diffuse parenchymal lung disease. Of all the ILDs, the honey comb pattern is most common in idiopathic interstitial pneumonias or in idiopathic nonspecific interstitial pneumonia (NSIP). As the name suggests, the pneumonia like condition of the lung has no known cause.
Honeycomb changes are also seen in autoimmune diseases such as sarcoidosis, lupus, rheumatoid arthritis, Sjogren’s syndrome, scleroderma etc. This group of diseases also also called as Collagen vascular diseases (CVDs). Of these, you have RA and Sjogren’s. If you have taken methotrexate for RA, then this drug too can precipitate ILD.
This is a serious condition. Prognosis will depend on the severity of the honeycomb pattern. There is nothing much which can be done, except keeping the RA and Sjogren’s flares under control. Also corticosteroids may be prescribed to reduce inflammation. You may also need oxygen therapy.
If you clear your throat a lot, then you could also be having a bad gastric reflux. This can also contribute towards development of interstitial pneumonitis. Treating the reflux can really slow down further damage. Do discuss this with your doctor and get yourself examined. Take care!
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