High IgA and B12

[Vigil4nte]

Hey,

I asked this question on a number of forums, I have been testing high for Vitamin B12 and IgA for the last 2 years now, here are the latest results:

!B12/folate level - Abnormal - No Action
!serum Vitamin B12 - 1168 (191-663)

!Immunoglobulins - Abnormal pt contacted...
IgG - 10.7 g/L (5.4-16.1)
IgA -  4.14 g/L (0.80-2.80)
IgM - 0.88 g/L (0.50-1.90)

I was contacted by my GP and asked to make an appointment but they are no interested in following these results up, I have already been tested for blood cancers/myeloma and the like by a Haematologost but was told I am fine and discharged.

However I have symptoms of something going on and these abnormal blood test results, I'm wondering if this could potentially be Lupus or some other autoimmune disease?

[Vigil4nte]

I'm assuming these 2 abnormal tests will be linked, as in both being caused for potentially the same reason?

[Vigil4nte]

Thanks for the replies guys I believe the High IgA is most definately polyclonal, paraprotein was checked on a previous test and was negative and the blood cancers have been checked out by the blood specialist are are also negative.

I believe this could be autoimmune but so far my doctors are refusing to send me on to rheumatology for their opinion.

[Red_Star]

Increased vitamin B12 serum may be due to:

* Supplementing with vitamin B12/high dietary intake of vitamin B12
* Active (functional) vitamin B12 deficiency
* MTHFR genetic defect
* Polycythaemia Rubra Vera  
* Leukaemia:
- Chronic myelogenous leukaemia aka chronic granulocytic leukaemia
- Acute myeloblastic leukaemia
- Acute promyelocytic leukaemia
* Hypereosinophilic syndrome
* Myelosclerosis
* Carcinomatosis
* Liver disease:
- Acute hepatitis
- Cirrhosis
- Chronic liver disease
- Hepatic coma
* Non-leukaemic leucocytosis
* Chloral Hydrate

***

Increased folic acid serum may be due to:

* Supplementing with folate/high dietary intake of folate
* Vitamin B12 deficiency
* MTHFR genetic defect
* Blind loop syndrome


***

Excerpt from Patient UK's article Globulins...

"Causes of raised immunoglobulin levels:

Electrophoresis will establish if these are polyclonal or monoclonal rises. The most common rise in immunoglobulin levels is polyclonal, and due to immune system activity caused by infection or autoimmune diseases.

* Polyclonal rises in immunoglobulin levels:
- Infections
- Autoimmune connective tissue diseases - rheumatoid arthritis, SLE, scleroderma
- Chronic active autoimmune hepatitis (IgG)
- Primary biliary cirrhosis (IgM)
- Chronic liver disease

* Monoclonal rises in one class of immunoglobulin level:
- Multiple myeloma (IgG or IgA usually)
- MGUS. The most common cause of monoclonal rise, and usually a benign condition
- CLL
- Non-Hodgkin's lymphoma
- Waldenström's macroglobulinaemia (IgM)
- Primary systemic amyloidosis"

[TheLightSeeker]

Hi Vigil4nte.

Here's an abstract from an article in "Clinical  Biochemistry" possibly pertinent to you:

---Significance of elevated cobalamin (vitamin B12) levels in blood---

Abstract
"Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Not surprisingly, a rise of the cobalamin concentration in serum is one of the diagnostic criteria for the latter two diseases. The increase in circulating cobalamin levels is predominantly caused by enhanced production of haptocorrin. Several liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin. This phenomenon is predominantly caused by cobalamin release during hepatic cytolysis and/or decreased cobalamin clearance by the affected liver. Altogether it can be concluded that an observed elevation of cobalamin in blood merits the a full diagnostic work up to assess the presence of disease."

Elevated levels of B12 and/or folate, may also indicate undermethylation issues, which will cause B12 or folate to accumulate in the serum, by not converting into their active methylated forms.
Look into gene mutations like the MTHFR , the most significant factor in methylation impairment  specifically the 677 and the 1248 mutations, which affect about 40-50% of the population, in various degrees.

Increased levels of IgA could have to do with the presence of some A/I condition,gamma-A myeloma, liver disease, chronic infection or other,
but you do not have enough information to narrow it down to anything specific at this point.

Hope this helps, however, please note that my comments are not intended to replace medical advice.

Best wishes.
Niko