i recently have been on antibiotics (amoxicillan) and i have had just one depo shot so far in september. is there any chance of pregnancy while on depo shot and antibiotics? i asked my doc and she said no, but then my pharmacist said yes! so which is it? again, i have only had one shot so far and my next isnt due until december 15th. i waited 3 weeks before i had unprotected sex after the first shot.