my daughter was sick 2 weeks ago and the doctor specifically didn't put her on prednisone because it would mess up her sugar level. He put her on asmantex, which was an inhaled steroid. it didn't impact her sugar level at all. The doctor did say if the steroid raised her sugar, she should increase her insulin. she uses lantus once a day and novolog each time she eats. the Dr. said to add one unit of novolog for every 100 over the 100s. i hope this helps!