The viral load is the highest within the 1st handful of week after infection and then drops. The antibodies are always produced and most people would produce them at 4 weeks. So this is why we recommend a antibody test at 3 months.
Edward W Hook, MD, Aug 28, 2010 07:37AM
Welcome back to the Forum. as you know, Dr. Handsfield and I share the forum. You got me as is appropriate given our interchange earlier this month and my resulting familiarity with your situation. FYI, the reason we share the forum is because we have worked together for nearly 30 years and while our verbiage styles vary, we have never disagreed on management strategies or advice to clients.
As for your question, the answer is that, in the absence of taking anti-HIV medications, the combination of a negative antibody test and a negative PCR at 28 days following a potential exposure is definitive evidence that you do not have HIV. Parenthetically I would add that you could get the same level of assurance from a negative DUO (combination p24 antigen/HIV antibody) test more inexpensively. When there is a discrepancy between symptoms and tests, the tests are ALWAYS correct. The symptoms of HIV that you had mentioned in earlier posts are non-specific. In contract the test results are highly standardized and perform with great precision. You do not have HIV. EWH
The PCR test you are referring to after 28 days is a DNA PCR test and not NAAT which seeks out the HIV RNA sooner, a window of 12 days.
So the question still remains. Will a NAAT test pick up if a person is HIV +/- after the acute phase is well over (around one month to 6 months)?
HIV RNA is highest during the acute phase (2-4 weeks after infection) but the levels are suppose to come down for months or years when HIV is dormant in the body. Will NAAT detect HIV at these low levels?
RNA PCR and DNA PCR are both NAAT tests. They are both extremely sensitive with the slight edge going to RNA. They will both pick up HIV at extremely low levels. So, to answer your question, it will be detected in the timframe you suggested.
Copyright 1994-2018MedHelp.All rights reserved. MedHelp is a division of Vitals Consumer Services, LLC.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.