Can Coreg loose its effectiveness

[tanyachi]

I have cardiomyopathy with an EF of 20-30%. I am 29 yrs old 120 lbs with no other health problems. I take 80 mgs extended release Coreg and 40 mgs of Benicar but my blood pressure still gets up to 170/105 and a resting heart rate of 120 sometimes. Is it possible that I just got used to the medication? I just had an angiogram and they gave me many medications but I was still fully awake which they said was odd. Could I possibly just have a high tolerance to medication? Also this is the first time that I really have been on any meds.

[cblmn7]

what ken keith said is right. also your body may have built a tolerance to the med and you need to get with your dr to find what works for your body. this happenens alot especially if you have been on a med for long periods of time

[kenkeith]

Yes, there may be a need to adjust or change medication due to a number of physicological causes as one ages, change of diet, live style, etc.  Your coreg dosage is quite high compared to mine which 12.5 mg twice a day.  You should talk to your doctor...it is not a good idea to be on any medication that is not helpful...