Aa
is there any problem of taking excessive aspirin
My age is 26,no family history of heart dicease
ECG--Normal
Blood Tests----Normal
Thread Mill-----Normal
CT-Angiogram---30%blockage(but doctor told no need to worry for another 30 years)
Ultra sound-Normal
I am facing chest pain with shoulder and jaw pain and some times neck pain when walking.I consulted the doctor and he has taken all the tests related to heart(ECG,Thread Mill test,Ultra sound,ct-angiogram,chest Ap x-ray) luckily all are normal and negative.But still I am getting pain when I am walking and even some times when I am at rest.Doctors are saying due to acidity also you will get these type of pains and he suggested me just ignore the pain.
Kindly tell me is there any problem to worry?
And also due to tension I have taken excessive aspirin,can any one kindly tell me by taking excessive aspirin is there any pblm?
ECG--Normal
Blood Tests----Normal
Thread Mill-----Normal
CT-Angiogram---30%blockage(but doctor told no need to worry for another 30 years)
Ultra sound-Normal
I am facing chest pain with shoulder and jaw pain and some times neck pain when walking.I consulted the doctor and he has taken all the tests related to heart(ECG,Thread Mill test,Ultra sound,ct-angiogram,chest Ap x-ray) luckily all are normal and negative.But still I am getting pain when I am walking and even some times when I am at rest.Doctors are saying due to acidity also you will get these type of pains and he suggested me just ignore the pain.
Kindly tell me is there any problem to worry?
And also due to tension I have taken excessive aspirin,can any one kindly tell me by taking excessive aspirin is there any pblm?
I have never really gotten into fine tuning knowledge of plaque formation; it has been a long time ago, but I do remember blood velocity and turbulance are involved in the formation plaque.
QUOTE: "I believe the chemical reaction of the oxidation involves attracting calcium to the mix also. Once a Stent is inserted 'properly', it should keep the material thin enough for new lumen to once again grow over the area". I believe you meant to say the "new intima".
The intima as I remember has an important role in monitoring blood flow, etc. to help regulate a systemic balance.
QUOTE: "I believe the chemical reaction of the oxidation involves attracting calcium to the mix also. Once a Stent is inserted 'properly', it should keep the material thin enough for new lumen to once again grow over the area". I believe you meant to say the "new intima".
The intima as I remember has an important role in monitoring blood flow, etc. to help regulate a systemic balance.
From what I can remember....
Fat lipids and other tiny particles in the blood such as red corpuscles and white cells etc get trapped in fractures caused by too much stress on the vessel. White cells of the immune system mutate into their largest variety, macrophages, and gobble up the material. However, they cannot destroy fat and so when they die, they are smeared along the artery lining in the form of foam cells. This is sticky and obviously other passing particles can stick to it until the outer layer oxidises through the oxygen in the blood, causing a plaque outer crust. This is not the body trying to keep the soft material against the wall as said by many people, it's simply a chemical reaction. If the layer of foam cells is very thin, it will be completely covered by new lumen once oxidised. Obviously if the layer is too thick, the vessel will not be able to cover it. Also if the layer is thick, then there will not be complete oxidation, only the outer layer will usually form a crust, leaving soft material inside. Sometimes angioplasty involves opening soft blockages which are very large but have not yet formed the plaque crust. Other times it involves dealing with the hard plaque which in some cases has to be trimmed down first.
I believe the chemical reaction of the oxidation involves attracting calcium to the mix also. Once a Stent is inserted 'properly', it should keep the material thin enough for new lumen to once again grow over the area. I believe the first stents were simply inserted post ballooning but excess plaque was not removed pre stenting. This caused more oxidation through the stent and more plaque formed causing restenosis. Maybe this is one of the reasons so much restenosis is occuring, maybe cardiologists arent removing the excess plaque first. When my LAD was recently treated the rotablator shattered the plaque in the main occlusion leaving clean (but rough) lumen. The rest of the LAD was stented but three areas needed some trimming first. The plaque was caught in a tiny net and dragged out.
Fat lipids and other tiny particles in the blood such as red corpuscles and white cells etc get trapped in fractures caused by too much stress on the vessel. White cells of the immune system mutate into their largest variety, macrophages, and gobble up the material. However, they cannot destroy fat and so when they die, they are smeared along the artery lining in the form of foam cells. This is sticky and obviously other passing particles can stick to it until the outer layer oxidises through the oxygen in the blood, causing a plaque outer crust. This is not the body trying to keep the soft material against the wall as said by many people, it's simply a chemical reaction. If the layer of foam cells is very thin, it will be completely covered by new lumen once oxidised. Obviously if the layer is too thick, the vessel will not be able to cover it. Also if the layer is thick, then there will not be complete oxidation, only the outer layer will usually form a crust, leaving soft material inside. Sometimes angioplasty involves opening soft blockages which are very large but have not yet formed the plaque crust. Other times it involves dealing with the hard plaque which in some cases has to be trimmed down first.
I believe the chemical reaction of the oxidation involves attracting calcium to the mix also. Once a Stent is inserted 'properly', it should keep the material thin enough for new lumen to once again grow over the area. I believe the first stents were simply inserted post ballooning but excess plaque was not removed pre stenting. This caused more oxidation through the stent and more plaque formed causing restenosis. Maybe this is one of the reasons so much restenosis is occuring, maybe cardiologists arent removing the excess plaque first. When my LAD was recently treated the rotablator shattered the plaque in the main occlusion leaving clean (but rough) lumen. The rest of the LAD was stented but three areas needed some trimming first. The plaque was caught in a tiny net and dragged out.
Thanks for the info re the scan. My primary physician says he wouldn't want me to have an angiogram because it has risks involved. I'll see what the cardiologist says. My primary physician looks at me sees female, 39, probably ok. I see what happened to my dad and realise we don't know what's going on inside.
As far as the mercury levels in fish go, some people still advise don't eat too much fish because of the mercury. We live in societies where heart disease is so common, surely the whole mercury thing is less important. It takes years to poison yourself with mercury anyway doesn't it?
I'm eating loads more fish, i don't care! LOL!
More fish, less chocolate.....lol
As far as the mercury levels in fish go, some people still advise don't eat too much fish because of the mercury. We live in societies where heart disease is so common, surely the whole mercury thing is less important. It takes years to poison yourself with mercury anyway doesn't it?
I'm eating loads more fish, i don't care! LOL!
More fish, less chocolate.....lol
I re-read your post and had missed your question regarding CT scan. The more advanced CT is the 128 or 256 slice (images) and images are re- assembled by the sofware, and it provides an output that captures moving heart images with the clarity a surgeon would see during an operation.
The test is an angiogram (contrast agent is injected) and takes about 20 minutes. One needs to hold their breath for about 10 seconds for each change of image angles. When I took the test, it was necessary to lower the heat rate below 60 bpm...with newer technology it is not necessary so the test can accommodate those who have a problem lowering their heart rate.
The test is an angiogram (contrast agent is injected) and takes about 20 minutes. One needs to hold their breath for about 10 seconds for each change of image angles. When I took the test, it was necessary to lower the heat rate below 60 bpm...with newer technology it is not necessary so the test can accommodate those who have a problem lowering their heart rate.
"The death rate from coronary heart disease in Japan has always been puzzlingly low," said Akira Sekikawa, M.D., Ph.D, an assistant professor of epidemiology at the University of Pittsburgh, PA, and an adjunct associate professor at Shiga University of Medical Science, Otsu, Japan. "Our study suggests that the very low rates of coronary heart disease among Japanese living in Japan may be due to their lifelong high consumption of fish."
That was my understanding and before I committed myself to that position on this thread I took into consideration living conditions may have changed in Japan, apparently it hasn't. There was a time were people said to eat to much fish can be ill advised based on the amount of mercury found in fish...That probably referred to tuna fish!? Thanks for the link.
That was my understanding and before I committed myself to that position on this thread I took into consideration living conditions may have changed in Japan, apparently it hasn't. There was a time were people said to eat to much fish can be ill advised based on the amount of mercury found in fish...That probably referred to tuna fish!? Thanks for the link.
You may be correct correct on the details, I haven't researched the subject to any extent and thanks for the information. Everything I have read refers to the composion of matter within the layers of the coronary vessel as soft plaque, and that matter does get into the vessel with a rupture, and there is a clot that is formed that puts an individual at a high risk for a heart attack.
The composition of matter within the lumen is referred to as hard plaque as I understand it and an aspirin does not reduce any risk of an MI if part of the matter breaks away and lodges at a site of vessel stenosis.
From what I have read it is the soft matter within the vessel that puts an individual at higher risk not the hard matter within lumen. If I remember correctly only 3% of MI's are caused by hard plaque and rupture of soft plaque much higher.
The composition of matter within the lumen is referred to as hard plaque as I understand it and an aspirin does not reduce any risk of an MI if part of the matter breaks away and lodges at a site of vessel stenosis.
From what I have read it is the soft matter within the vessel that puts an individual at higher risk not the hard matter within lumen. If I remember correctly only 3% of MI's are caused by hard plaque and rupture of soft plaque much higher.
"If soft plaque ruptures it will form a clot, and this clot can break away and lodge in an area of vessel stenosis, and a fatal heart attack. I believe anti-platelet medication may prevent the clot formation."
I think maybe you are confusing soft plaque with blood clots. Soft plaque (which isnt technically plaque anyway) is made up mostly from fats but is also mixed with a variety of other types of blood cells. I believe the plaque forms to try and keep this 'bulk' against the artery to stop it blocking the vessel further down the line. Aspirin doesn't stop atherosclerosis. The idea behind the aspirin is.....
If plaque fractures and blocks the vessel further down, OR, if plaque ruptures releasing the soft mass under it to form a blockage further down the line, this is known as the primary heart attack. The idea of aspirin is to prevent the secondary one, known commonly by cardiologists as the 'double whammy'. Where the plaque ruptured, platelets would ordinarily see this as damage and form a complete internal clot so now the vessels have 2 blockages. Aspirin is given to prevent this. Most heart attack deaths are caused when the double whammy occurs.
I think maybe you are confusing soft plaque with blood clots. Soft plaque (which isnt technically plaque anyway) is made up mostly from fats but is also mixed with a variety of other types of blood cells. I believe the plaque forms to try and keep this 'bulk' against the artery to stop it blocking the vessel further down the line. Aspirin doesn't stop atherosclerosis. The idea behind the aspirin is.....
If plaque fractures and blocks the vessel further down, OR, if plaque ruptures releasing the soft mass under it to form a blockage further down the line, this is known as the primary heart attack. The idea of aspirin is to prevent the secondary one, known commonly by cardiologists as the 'double whammy'. Where the plaque ruptured, platelets would ordinarily see this as damage and form a complete internal clot so now the vessels have 2 blockages. Aspirin is given to prevent this. Most heart attack deaths are caused when the double whammy occurs.
sorry i won't hijack this thread anymore, but interesting article on fish consumption and reduction of heart disease risk in japanese people
http://www.physorg.com/news136483659.html
http://www.physorg.com/news136483659.html
Thanks! What is the ct scan like? is it simple or do you have to swallow medicenes as well? I've got an appointment with a cardiologist soon and wondering whether to ask for that.
Re Japan.....nothing to do with the raw fish? If only it were that simple i guess.....
thanks again
Re Japan.....nothing to do with the raw fish? If only it were that simple i guess.....
thanks again
"In your opinion should everyone take aspirin?"
>>>Most doctors recommend a regimen of aspirin for those with heart disease and most often the 81 mg is the dose. A doctor on the expert forum states he goes with 325 mg if the patient has had a heart attack.
"I'm aware that you often talk about the soft plaque and that it is more dangerous. I expect that this is what happened to my dad because he never had angina before and did heavy work in the garden often, etc."
>>>>>>Statistics show more heart attacks are caused by the rupture of soft plaque into the artery lumen causing a clot...fewer heart attacks from the hard plaque that is in the lumen and sometimes breaks away.
"Do you know anything more about the formation of soft plaque? Is there anyway of knowing whether someone is more likely to develop this over a more stable plaque? Is soft plaque more of an accident, less likely to be genetically based? My dad was so healthy compared to so many people, i'm wondering was it just a fluke?"
>>>>I had a ct scan 128 slice angiogram that provides images of the coronary artery anatomy, and software output provided a calcium score of the 4 coronary arteries. The higher the score the more calcium buildup, and the greater are the odds for a rupture. Also, a cath angiogram equiped with an ultra sound device can image the inner layers of the artery as well.
There does appear to be a genetic component associated with CAD. Some populations (Japan?) don't have CAD compared to other populations. Also, some people can live an unhealthy lifestye, diet, not much exercise, etc and have no problem. If there is a family history, it is advised to follow a heart healthy regimen early in life.
_______________________________________
Blood thickness or thinness usually refers to anti-platelet count in the individual's blood. Prothrombin Time or PT and measures blood thickness an must be tested regularly for people on blood thinners (like those on Coumadin at risk for Blood Clots or Strokes). The "thinner" the blood the less likely to form clots.
If you are at risk for a stroke, the doctor should provide the PT test for your peace of mind.
.
>>>Most doctors recommend a regimen of aspirin for those with heart disease and most often the 81 mg is the dose. A doctor on the expert forum states he goes with 325 mg if the patient has had a heart attack.
"I'm aware that you often talk about the soft plaque and that it is more dangerous. I expect that this is what happened to my dad because he never had angina before and did heavy work in the garden often, etc."
>>>>>>Statistics show more heart attacks are caused by the rupture of soft plaque into the artery lumen causing a clot...fewer heart attacks from the hard plaque that is in the lumen and sometimes breaks away.
"Do you know anything more about the formation of soft plaque? Is there anyway of knowing whether someone is more likely to develop this over a more stable plaque? Is soft plaque more of an accident, less likely to be genetically based? My dad was so healthy compared to so many people, i'm wondering was it just a fluke?"
>>>>I had a ct scan 128 slice angiogram that provides images of the coronary artery anatomy, and software output provided a calcium score of the 4 coronary arteries. The higher the score the more calcium buildup, and the greater are the odds for a rupture. Also, a cath angiogram equiped with an ultra sound device can image the inner layers of the artery as well.
There does appear to be a genetic component associated with CAD. Some populations (Japan?) don't have CAD compared to other populations. Also, some people can live an unhealthy lifestye, diet, not much exercise, etc and have no problem. If there is a family history, it is advised to follow a heart healthy regimen early in life.
_______________________________________
Blood thickness or thinness usually refers to anti-platelet count in the individual's blood. Prothrombin Time or PT and measures blood thickness an must be tested regularly for people on blood thinners (like those on Coumadin at risk for Blood Clots or Strokes). The "thinner" the blood the less likely to form clots.
If you are at risk for a stroke, the doctor should provide the PT test for your peace of mind.
.
I find the aspirin comment interesting is what I said. I don't know how one can take that as criticism, whatever, for your information, I had bowel resection going on 14 years now for an oversized polylup, and often wish I had had regular checkups. The surgery became complicated with infection and I was rehosptialized. The problem may have begun when hospital personnel got me up in a day or two to start walking. This caused excessive bleeding, however, I was sent home after 3-4 days if I remember correctly and told to take massive doses of an anti-biotic medication. The next day or so I was rehospitalized with a high fever and throwing up every half hour a green substance (didn't taste bad, I believe it was bile?!) At the site of the resection there was inflammation causing stenosis and I have suffered for years with that problem. Have regular colonoscopy after the age of 50 is recommended.
Another related question, (sorry, hope it's ok!) is that my dad's sister has had two thromboses in her leg - once when she was 40 years old and pregnant and recently at age 69. She was told her blood was four times as thick as it should be.
My primary physician says that her clot and my dad's coronary thrombosis are unrelated. I know that different processes cause them, but could it be that his blood was too thick as well?
How do i get my doctor to test my blood thickness?
Hope you don't mind me asking and thanks for reading :-)
My primary physician says that her clot and my dad's coronary thrombosis are unrelated. I know that different processes cause them, but could it be that his blood was too thick as well?
How do i get my doctor to test my blood thickness?
Hope you don't mind me asking and thanks for reading :-)
In your opinion should everyone take aspirin?
I'm aware that you often talk about the soft plaque and that it is more dangerous. I expect that this is what happened to my dad because he never had angina before and did heavy work in the garden often, etc.
Do you know anything more about the formation of soft plaque? Is there anyway of knowing whether someone is more likely to develop this over a more stable plaque? Is soft plaque more of an accident, less likely to be genetically based? My dad was so healthy compared to so many people, i'm wondering was it just a fluke?
Thanks for your time :-)
I'm aware that you often talk about the soft plaque and that it is more dangerous. I expect that this is what happened to my dad because he never had angina before and did heavy work in the garden often, etc.
Do you know anything more about the formation of soft plaque? Is there anyway of knowing whether someone is more likely to develop this over a more stable plaque? Is soft plaque more of an accident, less likely to be genetically based? My dad was so healthy compared to so many people, i'm wondering was it just a fluke?
Thanks for your time :-)
When you have lost a spouse, brother-in-law, son and grandson to colon cancer, maybe then you will know more about what they are doing to prevent the polyps. I have a surviving 37 year old son who had his colon removed at 12. I have spent 30 years working with geneticists across the country and educating myself and family on what we can do to keep from losing another loved one to this. I never said it was a "high aspirin dosage" regimen, it varies but even 81mg is beneficial.
QUOTE: "Why dont they simply supply us with a few tablets to take IF we get sudden chest pains? After all, I had never taken an aspirin in my life until I had a heart attack and it still managed to help me recover".
If soft plaque ruptures it will form a clot, and this clot can break away and lodge in an area of vessel stenosis, and a fatal heart attack. I believe anti-platelet medication may prevent the clot formation. Additionally, some patients don't experience chest pain (angina) if it is a silent heart attack.
I take 81mg. Interesting, I have never heard larger dosages of aspirin prevent or reduce the size of polyps in a colon.
If soft plaque ruptures it will form a clot, and this clot can break away and lodge in an area of vessel stenosis, and a fatal heart attack. I believe anti-platelet medication may prevent the clot formation. Additionally, some patients don't experience chest pain (angina) if it is a silent heart attack.
I take 81mg. Interesting, I have never heard larger dosages of aspirin prevent or reduce the size of polyps in a colon.
Everyone is different. My husband takes 325mg of aspirin daily along with a blood thinner. He has never had a problem with excessive bleeding from a cut or injury. You can chew a 325mg aspirin if you feel you are having a heart attack and should carry a couple with you at all times for this purpose. 81mg is the usual dosage for most, but aspirin has been proven to help prevent, shrink and make colon polyps diasppear. It is very beneficial to the colon, and people prone to colon polyps are now put on an aspirin regimen for this reason. My son has duodenal polyps and has been put on an aspirin regimen due to the new research on this.
Yes that's correct, when a platelet detects an irregularity in an artery it emits a chemical attracting any passing platelets to adhere to it. These in turn send out signals to attract others and in no time at all, a clot forms.
Aspirin has been in the news frequently of late in the UK, stating that it should not be prescribed to anyone not suffering heart conditions. It has become apparent that aspirin raises the risk of internal bleeding more significantly than believed. It is considered worth the risk when artery disease is concerned. So, now I have to ask myself. Would I rather suffer a stroke or a brain hemorrhage. After some research I'm leaning towards prefering the idea of a stroke.
Why dont they simply supply us with a few tablets to take IF we get sudden chest pains? After all, I had never taken an aspirin in my life until I had a heart attack and it still managed to help me recover.
Aspirin has been in the news frequently of late in the UK, stating that it should not be prescribed to anyone not suffering heart conditions. It has become apparent that aspirin raises the risk of internal bleeding more significantly than believed. It is considered worth the risk when artery disease is concerned. So, now I have to ask myself. Would I rather suffer a stroke or a brain hemorrhage. After some research I'm leaning towards prefering the idea of a stroke.
Why dont they simply supply us with a few tablets to take IF we get sudden chest pains? After all, I had never taken an aspirin in my life until I had a heart attack and it still managed to help me recover.
Second to last sentence, "but enough to worry much about" should have been "but NOT enough to worry about".
This is an interesting question to me, at what point is an "Excessive amount of Aspirin? I need someone to correct me or someone to clarify my next statement... Aspirin is an anti-platelet or anti-coagulant , I.E. when there is little turbulence in the blood the platelets tend to want to stick together. Get enough of these stuck together platelets and you have a plug for the artery. Aspirin will help keep the platelets from sticking together. and this also includes external cuts where if you take too much aspirin the blood will not stop flowing out of that cut. And I just reminded my self that this also includes internal "cuts(?)" such as ulcers. My Mom takes 325mg aspirin and one of the big brand name blood thinners. She got a small cut which non of us thought anything about, just a bit bigger than a simple band-aid would take care of. Four hours later she wanted to go to the ER because it wouldn't stop bleeding and the ER nurses eventually tried some new material similar to band-aids but with clotting agents in bedded. A couple hours later the blood stopped flowing. total time from getting cut to blood stopping was 12 hours. This is an extreme case of "Excessive Aspirin" but it'll give you an idea of what to expect if you take far too much , or as you put it, Excessive aspirin".
Unless prescribed by a Dr. I wouldn't take more then 325mg of aspirin every few days, most heart patients take only 81mg per day. Your 30% blockage is enough to start eating right and exorcising right and ect.. but enough to worry much about. The other symptoms somebody else is going to have to tackle.
Unless prescribed by a Dr. I wouldn't take more then 325mg of aspirin every few days, most heart patients take only 81mg per day. Your 30% blockage is enough to start eating right and exorcising right and ect.. but enough to worry much about. The other symptoms somebody else is going to have to tackle.
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