Side effects of therapy

[Vireadeater]

Hi there,

I would like to discuss my Viread "side effects" with you. But first some relevant data.
Got diagnosed with Chronic Hep B in March 2011:

- Hbeag Negative
- Genotype D
- Grading 0-1
- Male

Started Viread (Tenofovir) in April:

- HBV DNA in April: 29.000
- HBV DNA in May: 45
- HBV DNA in August: Undetectable
- Hbsag in August: 30.000 (First time it got measured.)

So far so good, but here comes the "strange" data:

- ALT in April and before: Between 65 and 73
- ALT in  May after I started Viread: 93
- ALT in August: 93

Besides I have some "side effects" since I have been taking Viread that one could sum up as the typical symptoms of acute hepatitis b OR the side effects under Interferon:

- Pain over the location of the liver (on the right side of the abdomen, under the lower rib cage). I never experienced that before taking Viread
- Flu like symptoms: Muscle aches; Headache, Temperature, Tiredness. They come and go. Again I did not experience that before.

My doctor says this COULD be some immune reaction but wants to wait for the next results in November. Because she was also a bit surprised by the rise of my ALT since she figured it should have rather dropped considering the decrease of my HBV DNA.

Any ideas out there? Anyone who experienced something like that in therapy? Would be glad to hear your thoughts and opinions. And thanks for this community here!

Keep it up!

[stef2011]

you need hbsag count first and if very low like 100-200iu/ml an hbsab at 10miu/ml may have a meaning of clearance

in this case you need to boost hbsab by vitamin d or alinia

if hbsag is high like 1000-2000iu/ml hbsab so low makes nothing

[enolia]

An HBsAb count ≥10mIU/ml means that you are immune and that you are be protected! Did you talk to your doctor yet?
Are you sure your HBsAb count is 10mUI/ml???

[Vireadeater]

Alright thanks!

[stef2011]

hbsab to about 10miu/ml is not enough to clear hbv, you need it >1000miu/ml and hbsag to be low/undetctable

hbsab and hbsag detactable at the same time means hbsag has mutted and hbsb detected is useless

[Vireadeater]

@enolia: Got the ultrasound. Liver does not look abnormal. But for the bloodtest I will have to wait until November...

@all: One more question. Before I found out that I have chronic hepatitis in March 2011. I got vaccinated in 1998 (triple shot) and again in 2009 (one shot). So they say to be protected against HBV you need a titer >100. When the chronic Hep B got diagnosed I had a titer of 10. Finally the question: Does that mean that my immune system once reacted against HBV? Is that count valuable for anything: prognosis for therapy, date when I might have been infected (my doctor thinks before my first shots in 1998 but why do I have a bit of a titerthen?). Maybe someone here knows about this....thank you!

[joc2011]

@ 4est: Many Thanks. I actually have never checked my AgHBs quantitative. But i plan to do both AgHBs and AbHBs as soon as possible to track clearance. Will keep you all updated on implementation and results. Thanks again.