TT-034 hvc drug, do you think may be usefull for hbv too ?

[sorte]

Question for specialists, what do you think about their approach ?

http://blt.live.hqi.com.au/IRM/Company/ShowPage.aspx/PDFs/1526-10000000/FOURTHPATIENTDOSEDINHEPATITISCTRIAL

"Although at pre-clinical stage, the HBV program will leverage many of the features and advances from our other liver disease program, TT-034 for Hepatitis C, which is currently in Phase I/IIA human clinical trials."

http://www.benitec.com/pipeline/in-house-programs-detail#hepb

[StephenCastlecrag]

I wish I know. All I can opine is that no current drugs in clinical trials will be able to cure HBV on their own, all require a combination approach, the what and how are yet to be determined.

[sorte]

And which drug from phase I/II in your opinion is the most promising until real cure will be developed ?

[StephenCastlecrag]

Preclinical, yes. Safe, don't know. Effective, don't know.

My opinion.

[sorte]

so is there any approach now at preclinical or clinical studies which may be effective (not just block the virus but also remove cccDNA) and relatively safe ?

[StephenCastlecrag]

I am not a specialist, but here is my opinion.

TT-034 itself is not applicable to HBV, but the technology(ddRNAi) used can and is being developed to apply to HBV. But you must remember this: ddRNAi is gene therapy. It delivers to the nucleus of human cells, a gene that expressed one or more siRNA that can silence the translation of selected proteins expressed by the cccDNA of HBV. So this is similar to ARC520. However, ddRNAi actually introduces a gene into the liver cell infected by HBV. I think someone from Benitec once said, I can't remember the exact words, but paraphrasing: you must think carefully because once the gene is successfully introduced into the cell, it is there permanently.

So there it is, the gene must be delivered to a HBV infected cell and it will stay there permanently.

[stef2011]

They are all useless probably, i have not checked if there is any targetting immune system instead of the virus but i tell you i have free hbv drugs so they have to give drugs for free for me to be interested