Difference between Fibrosure and Hepascore?

[purplecat]

My Friend just got his recent test results back, Hepascore .86.  I have never seen Hepascore on any of my labs, only Fibrosure that was .76 from my Jan.13 tests.  Is there a difference?  I tried to find a table for Hepascore and could only find trials that said F2-F4.  My friend has never had a liver biopsy because he has a hemiangioma.  He had a Hepascore of .53 last years tests.  Can anyone tell me more about Hepascore.  We were discussing if he should wait for the combo pill with no interferon and ribavirin.  He did SOC a few years ago and did really bad on the interferon and Riba for 48 weeks.

What do you think?  I called my clinic to see if I could get him in the BMS trial but waiting list is really long.  I suggested he call his Dr on test result, and talk further.  He goes to Kaiser and was sent results with no follow through. Going to a .53 to .86 in one year is a big jump.  I think he should not wait and as soon as insurance kicks in do the Sovaldi with Interferon and Riba for the 12 weeks since he is 1A.  He said he never had ILB28 done.

I need some input from all the well informed MedHelp users.  Thanks

[purplecat]

Thanks for responding!  My friend is greater than .84 so cirrhosis is likely. The second say above .8 a 62% chance of cirrhosis.  Darn....
He can't have biopsy so we need to find a fibroscan in the San Francisco area.  Anyone know?  He has Kaiser Insurance and they do not have one.

I'm going to start checking.  Would be good to know where he stands and help push him for treatment.  He doesn't want to do interferon again and I'm telling him it is only 12 weeks and worth it!  Don't think he should wait for non interferon combo. Any feed back from anyone would be great. Thanks

[JimmyMose]

Just found this
Evaluation and Staging of Liver Fibrosis
http://www.hepatitisc.uw.edu/go/evaluation-staging-monitoring/evaluation-staging/core-concept/all

HepaScore
At values less than or equal to 0.2, the negative predictive value to exclude fibrosis is 98%. At values greater than or equal to 0.8 the positive predictive value for predicting cirrhosis is 62% HepaScore this method is good at excluding significant fibrosis but not as good at predicting cirrhosis, and it is recommended that for a HepaScore of greater than 0.2 an adjunct marker of fibrosis be used to predict cirrhosis.

NOTE: This site doesn't require registration to view the courses and you can see what what's they are teaching health care providers..
http://www.hepatitisc.uw.edu/
Hepatitis C Online Course
Welcome to this self-study, interactive course on Hepatitis C infection. The content is intended for medical providers  The project is brought to you from the University of Washington

[JimmyMose]

I found this
Hepascore – A New Liver
Function Test
http://www.jcdr.net/articles/pdf/1136/1444_2..pdf

[purplecat]

http://www.clinchem.org/content/51/10/1867.full
Found this link posted on past medhelp post.  This explains Hepascore pretty well.  My friend with score .86 has a high chance of cirrhosis but definately F2-F4.  I think he needs to find fibroscan location since he cannot have biopsy.