Aa
Harvoni with or without Rib
I will be starting Harvoni in a few weeks. My Doc suggested I do either 12 wks of Harvoni with Ribavirin or 24 wks. of just the Harvoni. We decided on the 24 wks of the Harvoni. I am wondering if adding the dastardly rib on the 24 wk course is advisable. My Doc is willing to add it if I want to. I couldn’t find a 24 wk study w/ that combo. Any insight would be appreciated.
I am GT 1a, stage 4, and have relapsed after treatment 3 times. 2 times with Peg/Rib and once w/ Incivick, peg, and rib. Have been infected over 30 years.
Here we go again.
I am GT 1a, stage 4, and have relapsed after treatment 3 times. 2 times with Peg/Rib and once w/ Incivick, peg, and rib. Have been infected over 30 years.
Here we go again.
" but in reading the archives last week way back to 2008, I saw many posts saying Riba stops mutation."
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Many people post erroneous information. I guess they just do not do the research to obtain the facts. One cannot go by what people post if they do not back up their posts with links to the facts, research, data.
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Many people post erroneous information. I guess they just do not do the research to obtain the facts. One cannot go by what people post if they do not back up their posts with links to the facts, research, data.
Yeah Pooh- I saw that "best answer" above where it says it causes mutation-good mutation, but in reading the archives last week way back to 2008, I saw many posts saying Riba stops mutation. Go Figure.
Nan,
This is such blessed news!! I am really (all are) so thankful for no Riba!
Please know, although in prayer for him, since last August, when I came on forum, THE ANTE HAS JUST BEEN UPPED!! And hope appears to spring eternal. I will be in unceasing prayer and thanks for his harvoni 24 and believing for this to be "CURE TIME"... YES!!
More than best:)
Randy
This is such blessed news!! I am really (all are) so thankful for no Riba!
Please know, although in prayer for him, since last August, when I came on forum, THE ANTE HAS JUST BEEN UPPED!! And hope appears to spring eternal. I will be in unceasing prayer and thanks for his harvoni 24 and believing for this to be "CURE TIME"... YES!!
More than best:)
Randy
I wish you the best this time. You have a lot of people praying and pulling for you.
Thank you all for your kind support. It is very much appreciated as I know you all are fighting this same battle.
I don't know how this will go but I do know there is no choice in this. Though very difficult, I don't regret what we went through last treatment because it kept his liver function and billirubin stable and there are no signs of liver cancer. God willing he will reach SVR this go round.
Dee - I spoke to his doctor specifically about the Rifaximin (Xifaxin). If you recall I took him off it during his last treatment because his HE actually got worse while taking the Sovaldi and Ribavirin along with the Xifaxin and improved when I stopped the Xifaxin. I had also called the Gilead helpline at the time and the nurse I spoke to said he shouldn't take it on treatment.
Well his doctor says that she has spoken to reps of Gilead and they said its okay to take Rifaximin with Harvoni as the Rifaximin has a different structure than the Rifampin and it does not enter the bloodstream.
I don't know how things will go this time bit if his HE gets worse again I will definitely stop the Xifaxin. It has been doing a great job keeping his HE at bay so I'm hoping he can stay on it.
She also said that the omeprazole he is taking must be taken four hours before or after the Harvoni as it does lower the effectiveness of the ledipasvir.
My best wishes to all of you.
Nan
I don't know how this will go but I do know there is no choice in this. Though very difficult, I don't regret what we went through last treatment because it kept his liver function and billirubin stable and there are no signs of liver cancer. God willing he will reach SVR this go round.
Dee - I spoke to his doctor specifically about the Rifaximin (Xifaxin). If you recall I took him off it during his last treatment because his HE actually got worse while taking the Sovaldi and Ribavirin along with the Xifaxin and improved when I stopped the Xifaxin. I had also called the Gilead helpline at the time and the nurse I spoke to said he shouldn't take it on treatment.
Well his doctor says that she has spoken to reps of Gilead and they said its okay to take Rifaximin with Harvoni as the Rifaximin has a different structure than the Rifampin and it does not enter the bloodstream.
I don't know how things will go this time bit if his HE gets worse again I will definitely stop the Xifaxin. It has been doing a great job keeping his HE at bay so I'm hoping he can stay on it.
She also said that the omeprazole he is taking must be taken four hours before or after the Harvoni as it does lower the effectiveness of the ledipasvir.
My best wishes to all of you.
Nan
I am very happy for you to be starting tx, you have a very good chance of curing it. I think above it said 96% with just the Harvoni which is impressive. Much better than the 40% with Peg and Riba that I was told back in 2008
My best to you
Dee.
Highest SVR12 rate (100%) in treatment-naive and treatment-experienced patients treated with ledipasvir/sofosbuvir and ribavirin for 24 weeks
My best to you
Dee.
Highest SVR12 rate (100%) in treatment-naive and treatment-experienced patients treated with ledipasvir/sofosbuvir and ribavirin for 24 weeks
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However, what the article is basically saying is that Riba causes a type of mutation that is beneficial in helping the immune system be able to get rid of Hep C and attain SVR.
We have to keep in mind that the drugs we take to get rid of Hep C do not actually kill the virus. The drugs either inhibit replication, interfere with replication, and/or boost the immune system to be strong enough to get rid of the Hep C.
Everything Riba does is not fully understood but it is well documented that Riba enhances the ability to get to SVR.
So, in this case, Riba is helping us to get rid of the virus by causing it to mutate in a beneficial way for those trying to get rid of Hep C.
These mutations are not at all the same as the resistant strains that can emerge during treatment with some of the drugs. The resistant strains that emerge during treatment with some of the drugs are strains that were already present even prior to starting treatment. They were just there is very small numbers. In that scenario, when the wild strains succumb to treatment, the resistant strains can emerge as dominant.
The Riba mutations discussed in this article (the one I provided the link to) are not those types of resistant strains. It is important to know this so people do not get frightened about mutations. Not all mutations are bad. The article is discussing mutations that Riba produces that are beneficial to people who are trying to get rid of Hep C.