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I am 52 year old white male, genotype 2. I have completed 19 of 24 week pegasysus+ribasphere 1200 milligrams/day treatment. I have experienced hypothyroidism, and I started taking Levothyroxine 0.05mg/one a day on Jan.24. I sprained my hand and the doctor gave me Naproxen 500mg/one twice a day, and I took this med Feb. 2 and 3. On Feb. 4, I felt stomach pain and nausea all day at work, and had diarrhea beginning Feb. 4 at night, and have had this plus terrible stomach pain and gurgling ever since. Doc had me start on Prilosec OTC for 6 weeks, and discontinue the Naproxen on Feb.5 as well as Immodium but have had no relief from diarrhea or stomach pain yet. I was unable to take either ribasphere or Levothyroxine on Feb. 5. Doctor insinuated that the 2 days of Naproxen could be source of my stomach problems, and could have caused an ulcer, which Prilosec is to treat.
I was undetectable at week 12, and my Jan.27 labwork indicated the following exceptions:
WBC 2.6 Normal 4.0-10.5
RDW 15.3 Normal 11.7-15
Mono 14.0 Normal 4-13
Neutrophils(ABS) 1.4 Normal 1.8-7.8
Glucose 103 Normal 65-99
ALT 59 Normal 0-55
I should say that I work in a hospital, and know that I could have picked up a virus, but did not have any fever.
Due to this diarrhea and painful stomach, I am thinking I cannot make myself take the ribasphere for the remainder weeks. Has anyone else had this stomach pain and what remedies did you have?
I was undetectable at week 12, and my Jan.27 labwork indicated the following exceptions:
WBC 2.6 Normal 4.0-10.5
RDW 15.3 Normal 11.7-15
Mono 14.0 Normal 4-13
Neutrophils(ABS) 1.4 Normal 1.8-7.8
Glucose 103 Normal 65-99
ALT 59 Normal 0-55
I should say that I work in a hospital, and know that I could have picked up a virus, but did not have any fever.
Due to this diarrhea and painful stomach, I am thinking I cannot make myself take the ribasphere for the remainder weeks. Has anyone else had this stomach pain and what remedies did you have?
About the same way a peashooter 'synergizes' with a canon. To talk about Metformin 'side effects' to someone on IFN would be laughable - if the whole subject of medical professionals ignoring 'borderline' blood sugar readings wasn't so serious.
"There are of course side effects associated with Metformin as all medications, the most common of which are gastrointestinal and some potential for thyroid, specifically TSH, issues."
How does this synergize with the impact interferon has on the thyroid?
How does this synergize with the impact interferon has on the thyroid?
"With a single fasting blood sugar of 103 and no other supporting data or monitoring"
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You have more than that. You have .....
Pre-treatment Glucose 104
12 week glucose 103 (same as 5.7 mmol/l)
HOMA of 3
A HOMA is an insulin resistance test. It's a formula that uses the results of a fasting blood sugar and a fasting insulin.
(FASTING BLOOD SUGAR in mmol/l X FASTING INSULIN divided by 22.5)
So with a blood sugar of 103 (same as 5.7 mmol/l), that means that your insulin would have to be 12 to get a HOMA of 3. And an insulin of 12 is high. And a HOMA of 3 means you're insulin resistant. And according to the American Diabetes Association, a fasting blood sugar of 103 is considered pre-diabetes. Results between 100 and 125 are considered "Impaired Fasting Glucose"
"Nearly one in four adults over the age of 25 has either diabetes or a condition known as PRE-DIABETES (in which blood glucose is higher than normal but not high enough to be diagnosed as Type 2 diabetes).
There are two conditions that fit into this category. One is called Impaired Fasting glucose (IFG) and the other is Impaired Glucose Tolerance (IGT).
IMPAIRED FASTING GLUCOSE is defined as glucose levels of 100 to 125 mg per dL in fasting patients.
Impaired Glucose Tolerance is defined as two-hour glucose levels of 140 to 199 mg per dL on the 75-g oral glucose tolerance test."
I would still talk to your doctor about it. You only have a few weeks left of treatment. Expecting you to loose weight to reduce the insulin resistance at this stage is unrealistic. They should have told you to do that months before starting your treatment.
Co
--------------------------
You have more than that. You have .....
Pre-treatment Glucose 104
12 week glucose 103 (same as 5.7 mmol/l)
HOMA of 3
A HOMA is an insulin resistance test. It's a formula that uses the results of a fasting blood sugar and a fasting insulin.
(FASTING BLOOD SUGAR in mmol/l X FASTING INSULIN divided by 22.5)
So with a blood sugar of 103 (same as 5.7 mmol/l), that means that your insulin would have to be 12 to get a HOMA of 3. And an insulin of 12 is high. And a HOMA of 3 means you're insulin resistant. And according to the American Diabetes Association, a fasting blood sugar of 103 is considered pre-diabetes. Results between 100 and 125 are considered "Impaired Fasting Glucose"
"Nearly one in four adults over the age of 25 has either diabetes or a condition known as PRE-DIABETES (in which blood glucose is higher than normal but not high enough to be diagnosed as Type 2 diabetes).
There are two conditions that fit into this category. One is called Impaired Fasting glucose (IFG) and the other is Impaired Glucose Tolerance (IGT).
IMPAIRED FASTING GLUCOSE is defined as glucose levels of 100 to 125 mg per dL in fasting patients.
Impaired Glucose Tolerance is defined as two-hour glucose levels of 140 to 199 mg per dL on the 75-g oral glucose tolerance test."
I would still talk to your doctor about it. You only have a few weeks left of treatment. Expecting you to loose weight to reduce the insulin resistance at this stage is unrealistic. They should have told you to do that months before starting your treatment.
Co
I asked the nurse today by e-mail if the Dr.would put me on Metformin for rest of my treatment, this is what she said: I seriously doubt that. He would refer you to either your PCP or an endocrinologist for an opinion or if he felt there was an indication.With a single fasting blood sugar of 103 and no other supporting data or monitoring (such as a glucose tolerance test and/or Hemoglobin A1C) I know that he would not prescribe any medication of this sort. His first recommendation still would be diet and exercise in combination with a low glycemic or low carbohydrate diet. There are of course side effects associated with Metformin as all medications, the most common of which are gastrointestinal and some potential for thyroid, specifically TSH, issues.
He has not been in the office today---but as I said, I will go over the articles sent and let you know what he has to say in this regard.
He has not been in the office today---but as I said, I will go over the articles sent and let you know what he has to say in this regard.
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