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10175413 tn?1427170251

Hep c treatment

Does smoking cigarettes interfere with Sov/ribivirin hep c Tx
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10175413 tn?1427170251
Ok then, that answered my question pretty good..I'm all the way down to 3 a day guess it's time to dump them all together.  It's like saying good bye to an old friend (j/k) !  lol.  Thank you both. It was another good day!  I hope the two of you are doing well. Thx for info

Deb

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Avatar universal
Hi there.   Lynn's right on the money.  
I also was a former smoker and quitting was the best thing I ever did in my life.  Since your going to become virus free, you may as well go all the way!
Good luck
....Kim
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683231 tn?1467323017
Hi

Found this but I am sure you know smoking is bad and smoking with liver disease is bad, bad. I smoked for 28 years pack a day or better. Quit in 2002 after about 5 or more tries to quit. My mom and grand-mother both died from emphysema. Might want to put quitting on your list of things to do for you.

I haven't seen anything about smoking being counterindicated per se while treating but can't imagine it would help with any side effects you may evperience

http://hepatitiscnewdrugs.blogspot.com/2011/02/preparing-for-hepatitis-c-treatment.html

Smoking and Fibrosis
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In this older study authors looked at liver biopsies from 310 patients with chronic HCV who were under going their first liver biopsy. They then went on to compare those biopsies with the patients who were current cigarette smokers (176 patients) or former cigarette smokers (56 patients). Last but not least, biopsies from patients who had never smoked (77 patients).


They found that current and former smokers had more inflammation and scarring of their livers than did nonsmokers. This finding could not be explained by other factors, such as concurrent alcohol use, that are known to aggravate the inflammation and scarring in hepatitis C. The authors concluded that smoking cigarettes could worsen their liver disease.

From HIV and Hepatitis
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Alcohol, Tobacco, and Cannabis All May Promote Liver Disease Progression in People with Chronic Hepatitis C
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In 2008 a study suggested that cigarette smoking may enhance activity grade in patients with chronic hepatitis C, thereby increasing progression of fibrosis. This assumption mostly relies on epidemiological evidences in the absence of pathogenic studies.

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Are we there yet ? Are you inspired to stop smoking ?


Smoking and Liver Cancer
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NEW YORK (Reuters Health) - There appears to be a synergistic link between smoking and hepatitis C virus (HCV) infection, leading to a more than 136-fold increased risk of hepatocellular carcinoma (HCC) in men, according to a team at The University of Texas MD Anderson Cancer Center.


.Well, we have established that cigarette smoking increases fibrosis, how about the increased risk in men for developing liver cancer. Here we go, published in 2008 in the International Journal of Cancer, researchers investigated HCC and the risk factors such as smoking in men and women who have HCV.


The Results:
· Men with HCV who smoke have a more than 136-fold increased risk of HCC.
· Women with HCV who consume large amounts of alcohol have a more than 13-fold increased risk of HCC.

The facts; smoking increases the risk of liver cancer by over 100 times. Does this inspire you to stop smoking?


While on HCV therapy I was forced to stop smoking. Not because I wanted to, but because I developed a cough that I can only compare to an old, ugly, void of any sex appeal house woman.

This is the kicker, I found out nine years later I had developed COPD. My point: Even if you have never smoked you may still experience a chronic cough during therapy, If you do smoke, be prepared to wake up in the middle of the night gasping for air.

I wanted to take this opportune moment to suggest that if you're a chronic smoker you may want to ask for a spirometry; (COPD) test before you begin treatment. If you are over forty and have smoked for more then 15 years, you may want to find out if you have COPD. Sadly, a horrendous thing to be diagnosed with, but a good thing to know before starting therapy.


Metabolic steatosis, HCV-induced steatosis and smoking, Oh My


This brings us to smoking and fatty liver disease. HCV has been proven to be caused directly from the virus. Genotype 3 patients are known to have a higher rate of fatty liver then other genotypes. .
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There are two different forms of steatosis (Fatty Liver) that may be found in people with HCV:
'

Metabolic steatosis can result from obesity, raised blood fat levels (hyperlipidemia), insulin resistance and type II diabetes and is similar to the type of fatty infiltration caused by excessive alcohol consumption and that is also found in Non-Alcoholic Fatty Liver (NASH).


Metabolic steatosis is not triggered by the hepatitis C virus; however the combination of this form of steatosis and the presence of HCV can lead to a more rapid progression of scarring or fibrosis.
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