Results from Telapravir study I was in 2 years ago

[toughluck]

I found out I got the real thing Telapravir. After week one 7-17-08. HCV RNA 384485 and log 6.6. 7-23-08. 271 and log 2.4. 7-31-08. 37 and log 1.6. 8-7-08 <25 and log <1.4. 8-14-08. <25 and log <1.4. 8-27-08. <25 and log <1.4. 9-10-08 214 and log 2.3. 9-23-08 5155 and log 3.7. 10-09-08. 409939 and log 5.6 11-17-08 9000924 and log 7.0. 1-08-09 1586982 and log 6.2. 2-12-09 853944 and log 5.9. looks like I was undetectable from 8-7-08 through sometime in sept 08. Because it was a blind study with no procrit or neupogen allowed, with my blood counts low they had to lower the rib and interferon doses. I believe that was the difference between me not beating the dragon.

[toughluck]

Sad thing is the Telapravir gave a real nasty rash, in the hospital 2 days and they tried to say was not related.

[RobertBeWell]

There are more trials every day that want people who previously failed tx. Granted, not as many as naive, but they seem to be increasing.

[fretboard]

Hi y'all, that's the pitts toughluck but you're not alone at all.  I'm surprised you weren't able to get in a follow-up trial.  I will have trouble finding another trial myself cause I was in the boceprevir trial in 11/08 but I had many issues and I stopped.  I just started a 3yr follow up trial, but I'm not on tx I am just in a study.  

I haven't been on this forum for a long time and I was under the impression that you (trinity4) cleared sorry to hear you didn't as I remember you put up one of the most strenuous amazing fights ever!!.  

[toughluck]

Thanks for the support, I don't know whether to see how long it takes for the dragon to kill me or try again.

[Trinity4]

It does s-u-c-k big time and thanks for giving it a go.  I also respect those who have done trials.  Those numbers show there is no way most of us can treat this beast without robust doses inf & riba.  Some have attained SVR with dose reductions but their immune system must have been extremely sensitive to the inf and riba even at reduced dosage.  

When my turn comes I know I'm going need every big gun available.  Quite sure I have a nasty strain of HCV, much like my disposition.  :)

Trin

[desrt]

That sux, but you and everyone else who labrats this stuff has my admiration and thanks. Will you be able to try Boceprevir if/when or did treating with Tele' give you a resistance that PI as well?