Aa
My four week PCR results-comments welcome.
I recently posted that I had commenced re-treatment post relapse after 48 weeks treatment.
Previously I had been a three time non-responder.
Quite a few of you were kind enough to wish me well.
Geno 1a/1b.
Baseline RNA 805000 iu.
Four week result 415 i.u
Promising BUT spiralling hgb and lack of success with procrit has meant reducing riba to just 400mg per day for the time being.
My doctor (top man in the Hep C world) says that the riba build up in my system is so prolific that the low dose could be perfectly efficacious.
Another complication has been the developement of kidney dysfunction and a kidney biopsy.
A renal specialist is going to make a call as to whether the nephritis is caused by the hep or the treatment.If the latter I shall have to susoend treatment.
If anyone has input on either of the two clinical issues of low dose riba and the kidney problem I would be pleased to hear from you.
Previously I had been a three time non-responder.
Quite a few of you were kind enough to wish me well.
Geno 1a/1b.
Baseline RNA 805000 iu.
Four week result 415 i.u
Promising BUT spiralling hgb and lack of success with procrit has meant reducing riba to just 400mg per day for the time being.
My doctor (top man in the Hep C world) says that the riba build up in my system is so prolific that the low dose could be perfectly efficacious.
Another complication has been the developement of kidney dysfunction and a kidney biopsy.
A renal specialist is going to make a call as to whether the nephritis is caused by the hep or the treatment.If the latter I shall have to susoend treatment.
If anyone has input on either of the two clinical issues of low dose riba and the kidney problem I would be pleased to hear from you.
this means you should drink extra water just to be good to your kidneys.
i have noticed that when i drink more water and eat more fruits, i feel less tired from the tx that day.
my dad, a homeopath, is also a chronic kidney disease patient. he had stones and blood in his kidneys 20 years ago.
he has dissolved his stones with homeopathy, and a berberis preparation taken daily keeps him fit.
i have noticed that when i drink more water and eat more fruits, i feel less tired from the tx that day.
my dad, a homeopath, is also a chronic kidney disease patient. he had stones and blood in his kidneys 20 years ago.
he has dissolved his stones with homeopathy, and a berberis preparation taken daily keeps him fit.
Thanks the addition of Ribavirin found the right studies and I've now got a interest in Mongolian Gerbils :)) .
Just to let you know that the riba really affects everyone differently. I am post transplant so that might make a difference but I started on only 200 riba a day, progressed to 400/day. Never went to a higher dose in 70 weeks. Late UND but I did get there. Also had HBG around 9 the entire tx on procrit once a week. Had one drop to H&H 6/19 and had to be transfused. That stuff is potent. Please don't adjust it without someone knowing is my advise
If you go to "PubMed" or similar and search under "Lindhal" you will come up with a bunch of interesting studies in this vein. One of her earlier studies had to do with the relationship between anemia and serum riba levels. I do not believe it is available online and I had to hunt it down "old school" at a medical library.
Yeah, it was quite a trip for me. The famous 90% Lindahl study came out a week after I started treating and for the next three days I got hold of everything that group wrote and switched doctors to someone who would try something more agressive. The article was so new that I actually read it before the doc.
Problem was I upped my riba from 1200mg/day to 2000mg/day over a five day period, when I should have done it more gradually -- say over a six *week* period. I was under the erroneous impression that if I felt OK at 1400mg/day for a few days then it was OK to go to 1600mg, etc, etc. Of course, later found out that riba builds slowly in the system with around a 2-3 week lag between increased riba dosage and a decrease in hgb. I was in the process of researching how best to send my blood to Sweeden for HPLC testing when WHAM I was in the ER :) Needless to say, my enthusiasm for that protocol waned and I pretty much just tried to stay in the game (at 1200 mg/day) for the duration.
Knowing what I do now, I could probably design a regimen for myself to maximize riba absorption without ending up in the hospital but fortunatly that's purely academic. Riba is stong and potentially dangerous stuff and one should only "monkey" around with it under the supervision of a doctor who understands the consequences and is willing to intervene appropriately. In other words, do what I say, not what I did. LOL.
-- Jim
Yeah, it was quite a trip for me. The famous 90% Lindahl study came out a week after I started treating and for the next three days I got hold of everything that group wrote and switched doctors to someone who would try something more agressive. The article was so new that I actually read it before the doc.
Problem was I upped my riba from 1200mg/day to 2000mg/day over a five day period, when I should have done it more gradually -- say over a six *week* period. I was under the erroneous impression that if I felt OK at 1400mg/day for a few days then it was OK to go to 1600mg, etc, etc. Of course, later found out that riba builds slowly in the system with around a 2-3 week lag between increased riba dosage and a decrease in hgb. I was in the process of researching how best to send my blood to Sweeden for HPLC testing when WHAM I was in the ER :) Needless to say, my enthusiasm for that protocol waned and I pretty much just tried to stay in the game (at 1200 mg/day) for the duration.
Knowing what I do now, I could probably design a regimen for myself to maximize riba absorption without ending up in the hospital but fortunatly that's purely academic. Riba is stong and potentially dangerous stuff and one should only "monkey" around with it under the supervision of a doctor who understands the consequences and is willing to intervene appropriately. In other words, do what I say, not what I did. LOL.
-- Jim
I am sorry to hear you are dealing with kidney issues. Geez, can't anything just be easy?? I hope it can be resolved and soon. You have had so many challenges. Please keep us posted on what you find out. Hang in there.
citizen
I too have some of those same suspicions, that those who have to deal with anemia that requires Procrit seem to SVR more frequently. This is only from my observations here, but since my Hgb has never fallen below 10 and in fact this week is up to 12 makes me nervous. I hope it isn't a sign I will relapse again! Do you happen to have that study handy, the Swedish one?
citizen
I too have some of those same suspicions, that those who have to deal with anemia that requires Procrit seem to SVR more frequently. This is only from my observations here, but since my Hgb has never fallen below 10 and in fact this week is up to 12 makes me nervous. I hope it isn't a sign I will relapse again! Do you happen to have that study handy, the Swedish one?
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